DOI: 10.2337/dc07-2181 © 2008 by the American Diabetes Association
Bloodletting Ameliorates Insulin Sensitivity and Secretion in Parallel to Reducing Liver Iron in Carriers of HFE Gene MutationsResponse to Equitani et al.From the Department of Internal Medicine, University of Milano, Fondazione Policlinico Mangiagalli e Regina Elena Hospital, Milano, Italy Address correspondence to Prof. Silvia Fargion, Internal Medicine, UO Medicina Interna IB, University of Milano Fondazione Policlinico Mangiagalli e Regina Elena IRCCS, Via F Sforza 35, 20122 Milano, Italy. E-mail: silvia.fargion@unimi.it
Equitani et al. (1) reported on the effect of iron depletion by phlebotomy on insulin resistance and release in 17 carriers of mutations of hereditary hemochromatosis HFE gene with nonalcoholic fatty liver disease (NAFLD). They found that iron depletion ameliorated insulin sensitivity and secretion and reduced hepatic iron stores and nonalcoholic steatohepatitis activity score, and they concluded that results justify glucose tolerance testing and preventive iron depletion in asymptomatic
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