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Early Subclinical Atherosclerosis in Women With Previous Gestational Diabetes Mellitus

¹ Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
² Department of Radiology, University of Pisa, Pisa, Italy

Corresponding author: Dr. Graziano Di Cianni, Endocrinology and Metabolism, Ospedale di Cisanello, Via Paradisa, 2, I-56126 Pisa, Italy. E-mail: dicianni@immr.med.unipi.it

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To determine if women with previous gestational diabetes mellitus (pGDM), a population at high risk for type 2 diabetes and metabolic syndrome (1), have signs of subclinical atherosclerosis, we measured carotid intimal-medial thickness (IMT) and multiple cardiovascular risk factors in 28 women with and 24 without pGDM (control group) 2 years after delivery. A 75-g 2-h oral glucose tolerance test was performed for assessment of glucose tolerance, area under the glucose curve (AUC_gluc), insulin sensitivity index, homeostasis model assessment of insulin resistance (HOMA-IR), lipid profile, oxidized LDL (oxLDL), C-reactive protein (CRP), adiponectin, and fibrinogen. Family history, anthropometric parameters, and blood pressure were recorded. IMT was measured at four . . . [Full Text of this Article]

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