Table 3— Rank order of risk of antipsychotic drugs for diabetes-related factors (in order of decreasing value), adjusted for diagnosis, duration of antipsychotic treatment, other medications, family history of diabetes, ethnicity, and smoking habits
|
Clozapine |
Olanzapine |
Risperidone |
Conventional neuroleptics |
|
| Prevalence of diabetes |
1 |
2 |
4 |
3 |
| Hyperglycemia (fasting) |
1 |
2 |
3 |
4 |
| Hyperinsulinemia (fasting) |
2 |
1 |
3 |
4 |
| Elevated total cholesterol |
1 |
3 |
4 |
2 |
| Elevated triglycerides |
1 |
2 |
4 |
3 |
| Elevated BMI |
2 |
1 |
3 |
4 |
| Elevated plasma uric acid |
1 |
3 |
2 |
4 |
| Sum of ranks* |
9 |
14 |
23 |
24 |
|
Data are from Chue and Welch (50).
* The parameters assessed are not equivalent in their contribution to the pathology of diabetes or its cardiovascular complications. However, no attempt has been made to weight the sums of rank orders. Low rank order or rank sum equates high prevalence or risk.
