Diabetes Care
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Extract Freely available
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Dandona, P.
Right arrow Articles by Bandyopadhyay, A.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Dandona, P.
Right arrow Articles by Bandyopadhyay, A.
Social Bookmarking
Add to CiteULike   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
Diabetes Care 26:2222-2223, 2003
© 2003 by the American Diabetes Association, Inc.

Letters: Comments and Responses
Letter

Hyperglycemia After Myocardial Infarction

Response to Dhatariya

Paresh Dandona, MD, Ahmad Aljada, PHD and Arindam Bandyopadhyay, MD

From the Division of Endocrinology, Diabetes and Metabolism, State University of New York at Buffalo, Buffalo, New York; and Kaleida Health, Buffalo, New York

Address correspondence to Paresh Dandona, MD, PhD, Diabetes-Endocrinology Center of WNY, 3 Gates Circle, Buffalo, NY 14209. E-mail: pdandona{at}kaleidahealth.org.

We appreciate the comments of Dhatariya (1) in this issue of Diabetes Care. Clearly, insulin is the ultimate anabolic hormone that may not only keep inflammation at bay, but also regulate the appropriate utilization of metabolites such that it conserves protein and fat and prevents their breakdown. Its usefulness in preventing protein catabolism in the clinical setting was demonstrated in the 1980s. The key studies of Nair and colleagues (2,3) referred to by Dhatariya provide the scientific basis for this important insulin action. The next challenge is to determine how inflammation induces a state of protein catabolism and exactly how insulin exerts its beneficial effects against the background of inflammation.

It is also worth mentioning two other key actions of insulin described recently: 1) apo E-/- mice that develop atherosclerosis suppress this process when given insulin (4), and 2) insulin suppresses reperfusion-induced myocardial damage following ischemia in isolated rat heart, as well as reduces myocardial apoptosis (5).

We believe this is just the beginning of a new era in understanding insulin action beyond the conventional biochemical/metabolic paradigm that we have been accustomed to for the first 80 years of its life. As discussed in our commentary, as we understand more about these novel actions of insulin, its clinical application will expand.

References

  1. Dhatariya K: Hyperglycemia after myocardial infarction (Letter). Diabetes Care 26:2222, 2003[Free Full Text]
  2. Nair KS, Ford GC, Ekberg K, Fernqvist-Forbes E, Wahren J: Protein dynamics in whole body and in splanchnic and leg tissues in type I diabetic patients. J Clin Invest 95:2926–2937, 1995
  3. Nair KS, Ford GC, Halliday D: Effect of intravenous insulin treatment on in vivo whole body leucine kinetics and oxygen consumption in insulin-deprived type I diabetic patients. Metabolism 36:491–495, 1987[Medline]
  4. Shamir R, Shehadeh N, Rosenblat M, Eshach-Adiv O, Coleman R, Kaplan M, Hamoud S, Lischinsky S, Hayek T: Oral insulin supplementation attenuates atherosclerosis progression in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 23:104–110, 2003[Abstract/Free Full Text]
  5. Jonassen AK, Sack MN, Mjos OD, Yellon DM: Myocardial protection by insulin at reperfusion requires early administration and is mediated via Akt and p70s6 kinase cell-survival signaling. Circ Res 89:1191–1198, 2001[Abstract/Free Full Text]

Add to CiteULike CiteULike   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Diabetes CareHome page
P. Dandona, A. Aljada, and A. Bandyopadhyay
Hyperglycemia After Myocardial Infarction: Response to Dhatariya
Diabetes Care, July 1, 2003; 26(7): 2222 - 2223.
[Full Text] [PDF]

This Article
Right arrow Extract Freely available
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Dandona, P.
Right arrow Articles by Bandyopadhyay, A.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Dandona, P.
Right arrow Articles by Bandyopadhyay, A.
Social Bookmarking
Add to CiteULike   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Diabetes Diabetes Care Clinical Diabetes Diabetes Spectrum