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Specialist Nurse–Led Clinics to Improve Control of Hypertension and Hyperlipidemia in Diabetes

Economic analysis of the SPLINT trial

¹ School for Health, University of Durham, Stockton-on-Tees, U.K
² Department of Primary Care and General Practice, University of Birmingham, Birmingham, U.K
³ Department of Diabetes, Hope Hospital, Salford, U.K

Address correspondence and reprint requests to Professor James Mason, School for Health, University of Durham, Queen’s Campus, Wolfson Research Unit, University Boulevard, Stockton-on-Tees, TS17 6BH, U.K. E-mail: j.m.mason{at}durham.ac.uk

	ABSTRACT

TOP ABSTRACT INTRODUCTION RESEARCH DESIGN AND METHODS RESULTS CONCLUSIONS References

 
OBJECTIVE—To determine the cost-effectiveness of specialist nurse–led clinics provided to improve lipid and blood pressure control in diabetic patients receiving hospital-based care.

RESEARCH DESIGN AND METHODS—A policy of targeting improved care through specialist nurse–led clinics is evaluated using a novel method, linking the cost-effectiveness of antihypertensive and lipid-lowering treatments with the cost and level of behavioral change achieved by the specialist nurse–led clinics. Treatment cost-effectiveness is modeled from the U.K. Prospective Diabetes Study and Heart Protection Study treatment trials, whereas specialist nurse–led clinics are evaluated using the Specialist Nurse–Led Clinics to Improve Control of Hypertension and Hyperlipidemia in Diabetes (SPLINT) trial.

RESULTS—Good lipid and blood pressure control are cost-effective treatment goals for patients with diabetes. Modeling findings from treatment trials, blood pressure lowering is estimated to be cost saving and life prolonging (–$1,400/quality-adjusted life-year [QALY]), whereas lipid-lowering is estimated to be highly cost-effective ($8,230/QALY). Investing in nurse-led clinics to help achieve these benefits imposes an addition on treatment cost-effectiveness leading to higher estimates: $4,020/QALY and $19,950/QALY, respectively. For both clinics combined, the estimated cost-effectiveness is $9,070/QALY. Using an acceptability threshold of $50,000/QALY, the likelihood that blood pressure–lowering clinics are cost-effective is 77%, lipid clinics 99%, and combined clinics 83%.

CONCLUSIONS—A method is described for evaluating the cost-effectiveness of policies to change patient uptake of health care. Such policies are less attractive than treatment cost-effectiveness (which implies cost-less self-implementation). However, specialist nurse–led clinics, as an adjunct to hospital-based diabetic care, combining both lipid and blood pressure control, appear effective and likely to provide excellent value for money.

Abbreviations: HPS, Heart Protection Study • MI, myocardial infarction • QALY, quality-adjusted life-year • SPLINT, Specialist Nurse–Led Clinics to Improve Control of Hypertension and Hyperlipidemia in Diabetes • UKPDS, U.K. Prospective Diabetes Study

	INTRODUCTION

TOP ABSTRACT INTRODUCTION RESEARCH DESIGN AND METHODS RESULTS CONCLUSIONS References

 
Although there is abundant evidence that patients with diabetes benefit from interventions to lower cholesterol and blood pressure (1–3), there is less evidence to demonstrate how these findings can be translated into routine clinical practice. Influencing the health care delivered by clinicians or taken up by patients is an increasingly important policy objective in the health systems of developed countries. Where suboptimal care is identified, policymakers normally have to commit resources to influence behavior if desirable changes are to be achieved. A method for analyzing the economics of behavioral change in clinicians was recently published (4). The approach differentiated between treatment cost-effectiveness (the net costs and benefits of a treatment when provided) and policy cost-effectiveness (which combines treatment cost-effectiveness with the cost and magnitude of change achieved by an implementation method). Some interventions that improve uptake of health care provision are targeted at the patient rather than the clinician: examples include patient education and organizational changes such as improved clinic times. This article assesses the cost-effectiveness of improved blood pressure and cholesterol control, achieved by using specialist nurse–led clinics (5) as an adjunct to hospital-based diabetic care.

	RESEARCH DESIGN AND METHODS

TOP ABSTRACT INTRODUCTION RESEARCH DESIGN AND METHODS RESULTS CONCLUSIONS References

 
Specialist nurse–led clinics
In England, about one-half of people with diabetes have their care managed in hospitals, and the other half are managed in primary care. Diabetic information systems, supporting structured diabetes care, have improved the quality of care provided (6). To further improve care and try to achieve the blood pressure targets achieved in the U.K. Prospective Diabetes Study (UKPDS) (1), a specialist nurse–led intervention to treat and control hypertension and hyperlipidemia in patients with diabetes (SPLINT) was conducted and reported (5). In brief, SPLINT enrolled 1,407 subjects attending the diabetes center at Hope Hospital, Salford, U.K., for annual review with raised blood pressure (140/80 mmHg), raised total cholesterol (5.0 mmol/l), or both. Subjects were randomized to usual care or usual care with subsequent invitation to attend specialist nurse–led clinics. Patients with both raised blood pressure and hyperlipidemia were eligible for enrollment in either or both clinics. Because of the design of the study, a separate specialist nurse provided each intervention. In routine practice, it is anticipated that both interventions, along with glycemic control, would be provided by a single nurse providing holistic support for patients.

The two nurse specialists recruited for the study were registered nurses educated to degree level with 2 years previous clinical experience of the management of diabetes, hypertension and dyslipidemia, and patient education, and working as advisors to other health care professionals. They received additional training in the management of hypertension and dyslipidemia in patients with diabetes from the local clinicians (J.M.G. and J.P.N.) and pharmacists.

During an initial 45-min consultation, the specialist nurse discussed the reason for the visit, targets for their treatment, and reasons for these targets. Medications were reviewed and other key conditions likely to influence treatment were noted, such as poorly controlled diabetes. An accurate assessment of their presenting condition was made. For patients with hypertension, three measurements of blood pressure were taken using an Omron 705CP (Omron Health Care, Henfeld, U.K.), and the average of the latter two readings was recorded. Lifestyle factors were discussed, the patient’s willingness to adjust was assessed, and an individualized action plan was drawn up. At subsequent visits, lifestyle factors were reinforced and reviewed and medications were titrated according to response to the treatment and according to protocol.

The lipid specialist nurse–led clinic improved the proportion of patients achieving the cholesterol target (53.3 vs. 40.3%). The change in total cholesterol attributable to the intervention was –0.28 mmol/l (95% CI –0.44 to –0.13; P = 0.0004). The hypertension specialist nurse–led clinic improved the proportion of patients achieving the blood pressure target (26.6 vs. 24.1%), although the difference was not statistically significant: a reduction in mean arterial blood pressure of 1.2 mmHg (–1.7 to 4.0; P = 0.21).

Lipid and blood pressure lowering
The UKPDS research program enrolled 1,148 hypertensive patients (systolic/diastolic 160/90 mmHg) with newly diagnosed adult-onset diabetes to tight or routine blood pressure control (1,2). A significant reduction in mean arterial blood pressure was achieved by tight control after 1 year of 5.7 mmHg. Tight control achieved relative risk reductions in myocardial infarction (MI) of 21% (41 to –7%) and stroke of 44% (65 to 11%). Published economic analyses of intensive blood pressure control indicate that savings from reduced morbidity may completely or substantially offset costs of treatment and that intervention is highly cost-effective (7,8).

Published major trials of lipid lowering include patients both with and without diabetes. The recently published Heart Protection Study (HPS) found that statin treatment reduced mean total serum cholesterol by 1.7 mmol/l at 1 year. Statin use achieved relative risk reductions in MI of 27% (33 to 21%) and stroke of 25% (34 to 15%) (3). Several economic analyses have been conducted of the effect of lipid lowering in patients with diabetes (9,10), but their assumptions and findings are diverse.

Methods
There are a number of steps involved in evaluating a policy to influence patient uptake of health care (Fig. 1). Political, social, and organizational factors may also be important when research findings from different contexts are being applied locally. The technical data are used to address efficiency using a simple mathematical formula (Fig. 2). The formula links treatment and implementation through a surrogate outcome—in this instance, average reductions in blood pressure and lipid levels at 1 year (treatment trials: p_t; implementation trial: p_i). Occasionally, the value of changed behavior is an instant measurable benefit, such as a life saved when an accident is prevented. Often behavioral change is targeted at the management of chronic diseases where the benefits of better care only become apparent over time. Implementation trials in these areas do not aim to replicate treatment trials in terms of numbers of patients and duration of follow-up, since this would normally be unethical and certainly inefficient. Consequently, implementation trials need to choose a surrogate outcome also found in the treatment trials. If part of the change in the surrogate outcome seen in treatment trials is achieved in an implementation study using the same treatment, then under certain assumptions, implementation will reasonably achieve a proportion of the long-term benefit.

View larger version (32K): [in this window] [in a new window]   Figure 1— Assessing the value of a policy of behavioral change.

View larger version (31K): [in this window] [in a new window]   Figure 2— Policy assessment of the value of introducing a call center to improve glycemic control in patients with type 2 diabetes.

(1)

where CE_t is the treatment cost-effectiveness of improved blood pressure or lipid control modeled from the UKPDS and HPS trials. The loading term is composed of two ratios: the nurse-led clinic net cost per patient (c_i) per change in surrogate outcome (p_i) and the (inverted) treatment net health gain (b_t) per change in surrogate outcome (p_t).

If an implementation method is costless (c_i = 0), then policy and treatment cost-effectiveness are the same. If the same level of change is achieved in implementation and treatment trials, then (because p_i/p_t = 1) the policy cost-effectiveness becomes c_t + c_i divided by b_t, a simple cost loading on treatment cost-effectiveness. Otherwise, there is a weighting on the health benefit achieved (b_t) determined by proportion of change in the surrogate outcome (p_i/p_t).

The policy model involves a number of assumptions, for example, that patient populations and treatment are similar in implementation and treatment trials. Additionally, the persistence of behavioral change after 1 year has to be explored and modeled appropriately. If the implementation method needs to be reapplied periodically to maintain change, then a series of interventions need to be costed over time. This approach allows the discounting of future costs to be applied consistently for treatment and implementation. These issues are illustrated through the worked example of the specialist nurse–led clinic.

Modeling economic estimates
To provide consistent estimates of lifetime treatment costs and benefits for blood pressure and lipid lowering, a simple lifetime Markov model was constructed and evaluated (Fig. 3). A Markov model begins with a cohort of healthy diabetic patients and follows them over time. Each year, patients may die or experience a nonfatal MI or stroke. The model moves forward in annual steps until the cohort of patients are dead, and their cumulative experience is used to calculate average life-expectancy, quality-adjusted survival, and health care costs. The model was evaluated with and without drugs that lower the likelihood of disease. The difference between model estimates was used to calculate net costs and survival gains from treatments.

View larger version (20K): [in this window] [in a new window]   Figure 3— Transition state diagram for a model of cardiovascular disease.

The model applies Framingham risk equations each year to patients in the healthy state to calculate the risk of suffering a stroke or MI according to their age, sex, and cardiovascular risk factors (11–13). Framingham 30-year mortality data were used to calculate the risk of death each year for patients who have had a stroke or MI, adjusted by age and sex (14). National mortality statistics for England and Wales (15) were adjusted for diabetes (14) and provided the age- and sex-adjusted likelihood of dying each year from noncardiovascular causes.

To evaluate the effects of drugs, the predicted incidence of stroke and MI was reduced applying reported risk ratios and their CIs modeled as log-normal distributions. The risk ratio for blood pressure lowering was taken from the UKPDS (1) and for lipid lowering from the HPS (3). These two trials were chosen as most closely relevant to the SPLINT trial population. We did not attempt meta-analyses of trials because of the need to summarize the surrogate end point (not consistently reported across trials) as well as relative reductions in cardiovascular end points.

Costs of drugs, and acute and chronic treatment after stroke and MI were drawn from published sources (16–18). These costs were conservative, not reflecting broader costs of care borne by society or loss of earnings. Gamma distributions were fitted to treatment costs reflecting published ranges (19). The longer-term benefits and costs of treatment are unknown and have not been varied. The assumption is that treatment continues having the same relative benefit and costs year-on-year.

Uncertainty surrounding estimates from the treatment and policy models was explored using cost-effectiveness acceptability curves, generated from Monte Carlo analyses making 10,000 evaluations of each model. In the treatment model, parameters were sampled randomly from distributions for costs of acute and chronic stroke and MI, and risk ratios for blood pressure and lipid lowering. In the policy model, modeled distributions for net costs and benefits of treatment and changes in surrogate outcomes (from the SPLINT trial) were sampled randomly.

A commonly reported cost-effectiveness threshold for U.S. health care is $50,000/quality-adjusted life-year (QALY) (20): the likelihood that a policy of introducing specialist nurse–led clinics is more cost-effective than this threshold is reported and shown graphically.

	RESULTS

TOP ABSTRACT INTRODUCTION RESEARCH DESIGN AND METHODS RESULTS CONCLUSIONS References

 
Cost-effectiveness of specialist nurse–led clinics
Clinics were staffed by experienced specialist nurses. One 0.5 full-time equivalent nurse was used for each intervention, to which the cost of clerical support and clinic time was added. With on-costs (National Insurance and Superannuation) and a 40% institutional overhead, each nurse cost $23,075 per year, half time. (Costs have been converted from £ sterling to U.S. dollar, applying a World Health Organization general goods and services purchasing power parity: 1 US$ = £0.65.) The institutional overhead covered administrative support and some clerical support costs; some clerical work contacting patients and arranging repeat appointments was conducted by the specialist nurses. The clinic room rental cost was estimated at $3,845 per clinic per annum (16). Thus, the total cost of each clinic was estimated at $26,920 per annum. It was conservatively assumed that these clinics would have to be repeated annually over the remaining lifetime of patients to maintain changes in blood pressure and lipid control. In an economic analysis, future benefits and costs are valued progressively less the further they occur in the future: commonly they are discounted at a rate of 5% per annum. If a cohort of patients lives on average 16 years, the cost of the clinic in the first year is $26,920, in the second year the cost is $26,920/1.05 or $25,640, and in the 16th year the cost is $26,920/(1.05)¹⁶ or $12,330. Hence, the discounted future cost of providing the clinic for the cohort was estimated at just over $300,000 (Table 1). The discounted cost per patient (cost of the clinic divided by the patient caseload) was $888 for the lipid clinic and $605 for the blood pressure clinic.

Estimated lifetime cost-effectiveness values for treatments are shown in Table 2. Blood pressure lowering predicted net cost savings and survival gains; patients were predicted to live an average of 11 months longer (95% CI 3–19 months). Discounted lifetime net treatment costs for diabetic patients aged 60 years receiving antihypertensive therapy were estimated to be –$750 (a saving), although the 95% CI stretched from –$3,580 to $2,600. The model predicted the likelihood that antihypertensive therapy was cost neutral or saving in this patient group to be 62%.

The cost-effectiveness of blood pressure–and lipid-lowering treatment is reported as the cost per QALY gained and shown with future costs and benefits discounted at 0, 3, and 5%: both interventions are cost-effective at each of these rates. Findings were not particularly sensitive to the discount rate and reflected the distribution of both costs and benefits over time.

Policy model findings
Data from the treatment trials and SPLINT were combined to evaluate a policy of introducing specialist nurse–led clinics (Table 2). Introducing a specialist nurse–led clinic introduced loadings of $5,420/QALY and $11,720/QALY to blood pressure–and lipid-lowering treatment cost-effectiveness, respectively. Overall, the clinics remained good value for money, with cost-effectiveness estimated at $4,020/QALY and $19,950/QALY, respectively. The estimated cost-effectiveness of the combined clinic was $9,050/QALY. If the discount rate for future costs and benefits is lowered from 5 to 3 and 0%, the cost-effectiveness of the combined clinic reduces to $7,560/QALY and $5,420/QALY, respectively.

Uncertainty surrounding estimates is shown graphically in cost-effectiveness acceptability curves (Fig. 4). The effect of implementing the hypertension and lipid clinics is to place a loading or addition on treatment cost-effectiveness. For the hypertension clinic, this loading is less precisely known, reflecting the uncertainty in the SPLINT trial findings. Thus, although lipid-lowering treatment is less cost-effective than blood pressure–lowering treatment, the added value of the nurse clinic was estimated precisely in the SPLINT trial, leading to a steeply rising slope. For blood pressure lowering, the effect of the nurse clinic was measured imprecisely, leading to a much more shallow curve. Applying the threshold of $50,000/QALY, the likelihood that the blood pressure–lowering clinic is cost-effective is 77%, lipid clinic 99%, and combined clinic 83%. The sampled median cost-effectiveness values shown in the figure are similar, but not identical, to the tabulated precise mean values, which are calculated differently.

View larger version (25K): [in this window] [in a new window]   Figure 4— Cost-effectiveness acceptability curve for specialist nurse–led clinics. BP, blood pressure. *Median values (P = 0.5) shown may vary slightly from tabulated mean values.

	CONCLUSIONS

TOP ABSTRACT INTRODUCTION RESEARCH DESIGN AND METHODS RESULTS CONCLUSIONS References

Using the framework
The virtue of the policy model is it allows the value of behavioral change methods to be determined using efficient study designs: implementation findings can be combined with the long-term effect of improved treatment for chronic diseases. However, important assumptions have to be made when applying the model to a local setting.

First, it is assumed that the emerging benefits of treatment over time in the implementation trials and treatment trials are linearly proportionate (through the ratio p_i/p_t). Second, it must be assumed that implementation and treatment cohorts use similar profiles of treatment with similar costs. The persistence of behavioral change and the need for periodic reimplementation needs careful analysis: our analysis used the conservative cost assumption that the specialist nurse clinic will need to be reused fully by patients on an annual basis. An even more conservative scenario would be that patients fully reutilized the clinic, but it became progressively less effective at achieving change: this seems unlikely. A more optimistic scenario would be that after the first year, patients would need less clinic time. In support of our assumption, an evaluation of a computer-based clinical decision support system to prevent venous thromboembolism demonstrated the need for continuing implementation of the system to achieve continuing behavioral change (21).

If published estimates of treatment cost-effectiveness are used, then the similarity between local and trial-enrolled patients needs to be explored. However, our analysis provided bespoke treatment cost-effectiveness estimates for the Salford hospital care population.

The findings of the implementation studies may have to be assumed transferable not just to different localities but to different treatments and diseases. The costs of outreach may be anticipated to vary with economies of scale and by locality and country. Implementation studies that report units of component resources, disaggregated from their unit costs, will help users to derive a valid local cost of implementation by applying local utilization patterns and prices.

Implications for policymakers
This study demonstrates that the provision of specialist nurse–led clinics are likely to be cost-effective as adjunctive care lowering blood pressure and cholesterol in hospital-based management of diabetes. As such, these clinics appear an important step in improving the quality of care of patients with diabetes. The impact of the specialist nurse clinic is similar to other "resourced" behavioral change studies targeted at clinicians and patients (22). Concurrently with the SPLINT trial, we evaluated the use of specialist nurses to provide educational outreach and support to practice nurses in primary care. This trial (educational outreach in diabetes to encourage practice nurses to use primary care hypertension and hyperlipidemia guidelines [EDEN]) found no impact on blood pressure or lipid levels in patients (23). Two of the reasons identified were lack of new resources for practice nurses to take on the additional work, and poor communication between practice nurses (who saw patients) and general practitioners (who had to approve medication changes). Transparently, worthwhile change is more likely to occur when new resources are provided (in SPLINT, this was the provision of new specialist nurses and additional clinics), and the new activity is supported by and integrated with routine care.

The benefits of improved blood pressure and lipid control are such that investment in specialist nurse clinics appears good value for money. If specialist nurse clinics tackled both blood pressure and cholesterol control, as would be anticipated in clinical practice, then they might be cheaper to implement, although the success of the clinics may rest in part on their having a single objective. Further research with specialist nurse–led clinics seeking to improve the cardiovascular risk profile of hospital care–based diabetic patients through improved diet, blood pressure, lipids, and glycemic control would inform this issue.

	Acknowledgments

 
The SPLINT trial and this subsequent analysis were funded by an unrestricted academic grant from Pfizer U.K.

	Footnotes

 
J.M.M. has received an unrestricted research grant from Pfizer. N.F. has received consulting fees from Aventis Pharmaceuticals and research funding from Pfizer. J.M.G. and J.P.N. have received honoraria from Pfizer for speaking engagements.

A table elsewhere in this issue shows conventional and Système International (SI) units and conversion factors for many substances.

Received for publication June 21, 2004. Accepted for publication September 28, 2004.

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TOP ABSTRACT INTRODUCTION RESEARCH DESIGN AND METHODS RESULTS CONCLUSIONS References

 

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This Article Abstract Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Mason, J. M. Articles by New, J. P. Search for Related Content PubMed PubMed Citation Articles by Mason, J. M. Articles by New, J. P. Social Bookmarking                What's this?