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Statin Neuropathy Masquerading as Diabetic Autoimmune Polyneuropathy

Address correspondence and reprint requests to Tom Brooks Vaughan, MD, Division of Endocrinology, University of Alabama School of Medicine, Faculty Office Tower, Suite 758, 510 20th St. S., Birmingham, AL 35294. E-mail: brooks{at}uab.edu

Statin-induced neuropathy is increasingly described. Proposed mechanisms include an alteration in cholesterol synthesis, producing a disturbance in the cholesterol-rich neuronal membrane, or in the activity of ubiquinone (coenzyme Q10), a mitochondrial respiratory chain enzyme inhibited by statins leading to neuronal damage (1). The entire class is implicated, and both polyneuropathy and mononeuropathy have been described with improvement or even complete resolution occurring with cessation of therapy (1). In all cases, clinical improvement occurred soon after statins were discontinued, and in the absence of specific clinical, biochemical, or electrophysiological characteristics, this has become the key diagnostic feature of statin-induced neuropathy. To date, autonomic features accompanying symmetrical neuropathy have not been described.

We present an 18-year-old white female with type 1 diabetes for 5 years who, over several months, developed restless legs followed by parasthesias, nocturnal diarrhea, fecal incontinence, early satiety, and weight loss. Examination revealed loss of pinprick sensation to the upper arms and thighs accompanied by areflexia and loss of vibration sense, a fixed tachycardia, and orthostatic hypotension. Autoimmune demyelinating polyneuropathy was initially suspected due to the relatively rapid onset of symptoms and the combination of peripheral and autonomic findings. Neuroelectrophysiological studies showed evidence of axonal, sensory, and motor polyneuropathy but did not meet criteria for demyelination. Supportive therapy included gabapentin, clonazepam, metoclopramide, metronidazole, cholestyramine, and fludrocortisone.

Before further investigations began, it was noted that the subject had been taking atorvastatin despite very low lipid levels, and it was discontinued. Within 1 week, her symptoms improved dramatically. Within 6 months, the postural hypotension, diarrhea, and symptoms of gastroparesis had resolved, and all medicines other than insulin were discontinued. There remained a minimal decrease in vibration sense, areflexia, and loss of sensation to the wrist and ankle.

Isolated cases of statin-associated neuropathy have been reported since 1994 (1). Epidemiological and case-control studies from the U.K. and Denmark suggest elevated odds ratios (ORs) of 2.5 (95% CI 0.3–14.2) to 3.7 (1.8–7.6), respectively, for the development of neuropathy while on statin therapy (2,3). The OR jumped to 26.4 (7.8–45.4) in patients with confirmed neuropathy taking statins for >2 years (3).

The key to diagnosing statin-induced neuropathy is to discontinue the statin and observe for potential improvement. In conclusion, statins can infrequently cause an idiosyncratic somatic and autonomic neuropathy that, in the diabetic patient, will almost invariably be attributed to diabetes. Awareness of this association and a trial removal of the statin could result in restoration of neurological function and a much-improved quality of life in the diabetic patient.

Footnotes

D.S.H.B. has received honoraria from AstraZeneca.

REFERENCES

1. Backes JM, Howard PA: Association of HMG-CoA reductase inhibitors with neuropathy. Ann Pharmacother 37:274–278, 2003[Abstract/Free Full Text]
   
2. Gaist D, Rodriguez LA, Huerta C, Hallas J, Sindrup S: Are users of lipid-lowering drugs at increased risk of peripheral neuropathy? Eur J Clin Pharmacol 56:931–933, 2001[Medline]
   
3. Gaist D, Jeppesen U, Andersen M, Garcia Rodriguez LA, Hallas J, Sindrup SH: Statins and risk of polyneuropathy: a case-control study. Neurology 58:1333–1337, 2002[Abstract/Free Full Text]
   

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This Article Extract Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Vaughan, T. B. Articles by Bell, D. S.H. Search for Related Content PubMed PubMed Citation Articles by Vaughan, T. B. Articles by Bell, D. S.H. Social Bookmarking                What's this?