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Antihypertensive Medications and the Risk of Incident Type 2 Diabetes

Response to Gosmanov et al.

¹ Channing Laboratory and Renal Division, Brigham and Women’s Hospital, Boston, Massachusetts
² Departments of Nutrition and Epidemiology, Harvard School of Public Health, Boston, Massachusetts

Address correspondence to Eric N. Taylor, MD, MSc, Channing Laboratory, Third Floor, Brigham and Women’s Hospital, 181 Longwood Ave., Boston, MA 02115. E-mail: entaylor{at}partners.org

We thank Gosmanov et al. (1) for their comments. As stated in our article (2) and the accompanying editorial (3), data on the specific use of ACE inhibitors were obtained only in the Nurses’ Health Study (NHS) I and data for specific antihypertensive medication use in NHS II were limited to thiazide diuretic use. Thus, NHS II participants reporting the use of "other" antihypertensive medications may have been taking ß-blockers, calcium channel blockers, or ACE inhibitors, and Health Professional Follow-up Study participants reporting the use of "other" antihypertensive medications may have been taking ACE inhibitors. For each cohort, we can only speculate on the meaning of the "other" category risk estimates, which were generated by multivariate analyses that adjusted for the use of each class of antihypertensive drug. Of note, we performed subanalyses in each cohort restricted to participants treated with only one class of antihypertensive medication. These analyses excluded participants reporting the use of "other" antihypertensive agents. The positive relation between monotherapy and risk supports the conclusions of our primary analyses that thiazide diuretics (in all three cohorts) and ß-blockers (in NHS I and the Health Professional Follow-up Study) were independently associated with the development of incident diabetes.

References

1. Gosmanov AR, Connelly S, Lewis JB Jr, Gosmanov NR: Antihypertensive medications and the risk of incident type 2 diabetes (Letter). Diabetes Care 29:2334, 2006[Free Full Text]
   
2. Taylor EN, Hu FB, Curhan GC: Antihypertensive medications and the risk of incident type 2 diabetes. Diabetes Care 29:1065–1070, 2006[Abstract/Free Full Text]
   
3. Sarafidis PA, Bakris GL: Antihypertensive therapy and the risk of new-onset diabetes. Diabetes Care 29:1167–1169, 2006[Free Full Text]
   

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This Article Extract Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Taylor, E. N. Articles by Curhan, G. C. Search for Related Content PubMed Articles by Taylor, E. N. Articles by Curhan, G. C. Social Bookmarking                What's this?