HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Abstract Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Perel, P. Articles by Marmot, M. Search for Related Content PubMed PubMed Citation Articles by Perel, P. Articles by Marmot, M. Social Bookmarking                What's this?

Household Wealth and the Metabolic Syndrome in the Whitehall II Study

¹ International Centre for Health and Society, Department of Epidemiology and Public Health, University College London, London, U.K
² Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, U.K.

Address correspondence and reprint requests to Claudia Langenberg, MD, International Centre for Health and Society, Department of Epidemiology and Public Health, University College London, 1-19 Torrington Place, London WC1E 6BT, U.K. E-mail: c.langenberg{at}ucl.ac.uk

	ABSTRACT

TOP ABSTRACT INTRODUCTION RESEARCH DESIGN AND METHODS-- RESULTS-- CONCLUSIONS-- APPENDIX References

 
OBJECTIVE—The metabolic syndrome is more common in socially disadvantaged groups. Inequalities in household wealth are currently widening and may contribute to the increasing prevalence of the metabolic syndrome.

RESEARCH DESIGN AND METHODS—This was a cross-sectional analysis of 1,509 women and 4,090 men (aged 45.2–68.9 years) of an occupational cohort study of 20 civil service departments located in London, U.K. Components of the metabolic syndrome were measured in 1997–1999 and defined using a modified World Health Organization definition.

RESULTS—Own income, household income, and wealth were each strongly and inversely associated with the metabolic syndrome in both sexes (P_trend < 0.001). Within each group of household wealth, the prevalence of the metabolic syndrome was higher in men than in women. Sex differences became smaller with decreasing household wealth, with the prevalence of the metabolic syndrome rising from 12.0 and 5.7% in the wealthiest men and women, respectively, to corresponding values of 23.6 and 20.1% in the poorest group. The odds ratio (95% CI) associated with each decrease of one category in household wealth was 1.25 (1.03–1.50) in men and 1.69 (1.18–2.41) in women, adjusting for age, household members, occupational grade, education, father’s social class, personal and household income, ethnic group, smoking, alcohol intake, diet, and physical activity.

CONCLUSIONS— Household wealth, a measure of assets accumulated over decades and generations, is strongly and inversely associated with the metabolic syndrome. Future research should explore the potential mechanisms by which wealth inequalities are associated with the metabolic syndrome.

Abbreviations: HOMA, homeostasis model assessment • WHO, World Health Organization

	INTRODUCTION

TOP ABSTRACT INTRODUCTION RESEARCH DESIGN AND METHODS-- RESULTS-- CONCLUSIONS-- APPENDIX References

 
The prevalence of the metabolic syndrome has risen rapidly in parallel with the global obesity epidemic (1,2) and now affects up to a quarter of men and women in the U.S. and Europe (2,3). Prospective studies using agreed upon (4,5), although differing, diagnostic criteria have shown that the rate of fatal and nonfatal cardiovascular events is greatly elevated in individuals with the metabolic syndrome (6–9). Although the definition and prognostic value of the metabolic syndrome are still a matter of debate (10), its high prevalence and associated morbidity and mortality make it an increasingly important public health problem. The prevalence of the metabolic syndrome, like that of diabetes, is higher in socially disadvantaged groups (11–16) and is of particular interest as it may provide clues about influences on the social gradient in cardiovascular and other common chronic diseases (17). Conventionally, education, occupation, and, to a lesser extent, income (18) have been studied, yet economists clearly distinguish between income and wealth, a distinction not commonly made in the health field. Inequalities in income and wealth are high in Britain and the U.S. (19), and inequalities in wealth have continued to increase. Wealth reflects the accumulation of personal and intergenerational assets over time and is more unequally distributed among the population (20,21). It provides information about population differences in past and long-term financial security and may thus be a better summary measure of potentially modifiable factors, such as excess caloric intake, poor nutrition, cardiorespiratory fitness, or psychosocial stress that influence obesity, low-grade inflammation and metabolic disturbances, compared with income alone or other indicators of social disadvantage. On the background of increasing prevalences in obesity, the metabolic syndrome, and widening inequalities in wealth, it is important to understand which factors underlie socioeconomic differences in this common disorder and the current demographic trend.

In the present study we investigated 1) whether the prevalence of metabolic syndrome and its components differs according to household wealth and 2) to what extent behavioral, economic, social, and educational differences contribute to this association in men and women of the Whitehall II study.

	RESEARCH DESIGN AND METHODS—

TOP ABSTRACT INTRODUCTION RESEARCH DESIGN AND METHODS-- RESULTS-- CONCLUSIONS-- APPENDIX References

 
The target population for the Whitehall II study was all London-based office staff, aged 35–55 years, working in 20 civil service departments. The cohort consisted of 10,308 participants (6,895 men and 3,413 women) at the first phase in 1985 (22). A total of 6,552 participants completed the phase 5 screening examination (1997–1999) and of these 5,599 (4,090 men and 1,509 women aged 45.2–68.9 years) had information on each component of the metabolic syndrome as well as household wealth. Participants were predominantly white European (91.5%), 2.8% were Afro-Caribbean, 4.3% South Asian, and 1.4% reported other ethnic origins. Each phase of the Whitehall II study has received ethical approval from the research ethics committee of University College London Hospitals.

Measurements
Metabolic syndrome.
The metabolic syndrome and its components were defined using a modified World Health Organization (WHO) definition (Appendix) (4), which includes the presence of diabetes, impaired glucose tolerance, and impaired fasting glucose or insulin resistance, plus at least two of the following: obesity, dyslipidemia, or hypertension. This definition varies from standard WHO recommendations in two ways: first, insulin resistance was defined using the homeostasis model assessment (HOMA) score instead of the euglycemic clamp technique; and second, the criterion of microalbuminuria was omitted because of a lack of urine samples. Our study is in line with the European Group for the Study of Insulin Resistance, whose modified definition of the metabolic syndrome also does not include microalbuminuria and with other studies using HOMA scores to assess insulin resistance (3,9,15).

At the phase 5 screening examination, height, weight, waist and hip circumferences, blood pressure, and glucose and lipid levels were measured, as described previously (12,23,24). Whole body insulin resistance in the fasting state was assessed using the HOMA for insulin resistance (25).

Socioeconomic indicators and health-related behavior.
Information on demographic, socioeconomic, and behavioral variables was obtained from the self-completed questionnaires administered at phase 1 (childhood social class and adult employment grade) or phase 5 (all other variables). Childhood social class was based on father’s occupation and grouped according to the Registrar General’s Classification; the original six categories were collapsed into four (12). Education level was based on the highest educational qualification achieved and classified into four groups: higher education, advanced secondary qualifications, ordinary secondary qualifications, or no academic qualification. On the basis of salary and work role, the civil service defines a hierarchy of employment grades, and participants were assigned to one of three levels: unified grades 1–7 (high employment grades), executive officers (middle grades), and clerical and support staff (lower grades) (26).

Smoking status distinguished never-smokers from previous and current smokers. Alcohol intake was based on consumption during the week before the interview and was grouped into five categories based on sensible drinking recommendations (27). Physical activity distinguished participants with no vigorous physical activity, those with <1.5 and 1.5 h of vigorous physical activity per week (28). A healthy diet indicator (scored 0–3) was constructed as previously reported (29).

Income and wealth.
All financial indicators were derived from phase 5 questionnaires. Precoded categories were collapsed to form four groups in descending order. Annual personal income included the "amount received annually from salary or wages, pensions, benefits, and allowances before deduction of tax"; categories were £50,000, £25,000–49,999, £15,000–24,999, and <£15,000. Annual household income included the "total annual household income from any source, including personal income"; categories were £60,000, £40,000–59,999, £20,000–39,999, and <£20,000. Household wealth included the "amount of money the respondent would have if s/he cashed in all household assets and paid off all debts"; categories were £500,000, £100,000–499,999, £40,000–99,999, and <£40,000.

Statistical analysis
Prevalences or mean levels of metabolic syndrome components and socioeconomic characteristics were estimated for each household wealth category, and tests for linear trend were carried out. Logistic regression was then used to calculate age-adjusted odds ratios (ORs) and 95% CIs for the metabolic syndrome across all socioeconomic indicators, separately for men and women, using the most advantaged groups as reference categories and testing for linear trend. Adjusted analyses were performed in several steps: adjusting for age or age and number of household members; additionally including behavioral and demographic factors; and also adding all other socioeconomic variables first separately and then jointly to the model. Analyses were performed using STATA 8.0 (release 8.0, 2003; StatCorp, College Station, TX).

	RESULTS—

TOP ABSTRACT INTRODUCTION RESEARCH DESIGN AND METHODS-- RESULTS-- CONCLUSIONS-- APPENDIX References

 
Participants with greater wealth were significantly more likely to be married or cohabiting, have greater personal and household income, have higher education, employment grade, and father’s social class, and have a greater number of household members (Table 1). Likewise, insulin resistance, obesity, dyslipidemia, and the metabolic syndrome were all linearly and significantly associated with household wealth in both men and women (P_trend < 0.002 in each case) (Table 1) and with lowest prevalences in the wealthiest group (Table 1). A significant trend for diabetes was shown in men, but not in women, whereas the reverse was true for hypertension. Impaired glucose tolerance and fasting glucose did not differ significantly by household wealth in men or women and by use of binary or continuous glucose measures. Within each group of household wealth, the prevalence of having the metabolic syndrome was higher in men than in women (Table 1). This difference became smaller with decreasing household wealth; prevalence rose from 12.0 and 5.7% in the wealthiest men and women, respectively, to corresponding values of 23.6 and 20.1% in the poorest group.

	CONCLUSIONS—

TOP ABSTRACT INTRODUCTION RESEARCH DESIGN AND METHODS-- RESULTS-- CONCLUSIONS-- APPENDIX References

The prevalence of the metabolic syndrome also differed significantly by household and personal income and adult employment grade in both sexes and by father’s social class in women; however, these associations were attenuated and did not remain statistically significant in multivariate analyses. Social inequalities in the metabolic syndrome have been shown in several studies using different indicators of socioeconomic position across the life course, including childhood and adult social position and education (12–16,30). In contrast, we are aware of only one study reporting that limited household income is associated with a greater risk of the metabolic syndrome in a sex-specific manner (18), and in no previous study has the role of wealth in socioeconomic differences in metabolic risk been considered. Socioeconomic indicators such as education, income, and occupation are limited in their ability to capture the complex forces that dominate social structure (31). Although income and wealth are related, their distributions and definitions differ (21), and household wealth was only weakly correlated with personal or household income in this study (correlation coefficients 0.25 and 0.34, respectively). Whereas this may partly reflect measurement error of wealth, associations between wealth and the metabolic syndrome remained strong after adjustment for other factors measured with greater precision. Inequalities in wealth are greater than those of income and have continued to widen (20). Household wealth includes not only income and savings but also all marketable assets and thus captures the accumulation of personal and intergenerational capital and assets from all household members over time. Continuing material security associated with wealth may benefit health through a sense of protection, autonomy, and prestige, and this may also contribute to the established link between material assets such as car or house ownership and health (32). The stronger associations between wealth and the metabolic syndrome suggest that wealth may be a better, or more comprehensive, indicator of actual socioeconomic situation and associated long-term material and psychological security, living conditions, and life choices affecting health, compared with other socioeconomic measures considered in this study. Corresponding with one earlier report of sex differences in the association between household income and the metabolic syndrome (18), we found some evidence for the influence of household wealth being stronger in women, compared with men. Despite significant sex differences in the distribution of all socioeconomic variables, with higher proportions of women in the more disadvantaged groups (all P values < 0.001, data not shown), behavioral and socioeconomic factors accounted for only some of this difference in fully adjusted models. Future studies exploring why women may be more susceptible to the influence of economic disadvantage than men could help to identify the underlying mechanisms through which unequal access to economic resources influences metabolic and ultimately cardiovascular risk.

To our knowledge, this is the first study to report on the association between the distribution of wealth and the metabolic syndrome. However, some limitations should be noted. All subjects are participants of the Whitehall II study, a large prospective occupational cohort of London civil servants, the majority of whom are white, nonmanual British office workers; our results may therefore not apply to other ethnic groups, manual social classes, the unemployed, or nonworking populations or other countries or parts of the world.

Different diagnostic criteria have been published for the definition of the metabolic syndrome (4,5), and its prevalence is difficult to compare because of differences in the definition used and population characteristics (33). In this study, the metabolic syndrome was based on the definition published by the WHO for epidemiological studies. Using the same definition, prevalences in European populations varied from 7 to 39% in men and from 5 to 24% in women (34). A greater prevalence in men of both the metabolic syndrome and obesity, compared with that in women, has been also reported in other studies using the standard WHO definition (35). The choice of diagnostic criteria may influence the association between wealth and the metabolic syndrome, and it is therefore reassuring that consistent associations were observed with several of its components.

All socioeconomic measures are based on participants’ self-report, which for father’s social class involved recall over a long period. Greater measurement error may lead to an underestimation of the relative influence of father’s social class, compared with socioeconomic indicators measured contemporaneously, if recall is nondifferential with regard to metabolic syndrome status. Baseline employment grade was chosen instead of grade at phase 5 for the following reasons: 1) because the number of participants with available information would be maximized; 2) because reverse causality, in which baseline morbidity may simultaneously affect later employment grade through restriction of social mobility as well as development of the metabolic syndrome, would be minimized; and 3) because grade at phase 5 reflects mobility for those who remained in the civil service but cuts short the trajectories of those who left the civil service to take up employment elsewhere. The relatively stronger association between household income and the metabolic syndrome in women indicates that adult employment grade may be a poorer marker of adult social position for women in the Whitehall II study than it is for men. However, our findings remained unchanged when partner’s social class instead of women’s own employment grade was used (data not shown). Wealth may be influenced by preexisting ill health; however, household wealth in this cohort has been shown to be the financial indicator less influenced by preexisting illness (36).

In summary, greater household wealth, a measure of assets accumulated over decades and generations, is associated with a decreased prevalence of the metabolic syndrome in both men and women in this occupational cohort of civil servants. This association is independent of several socioeconomic indicators, including personal and household income. Although, on average, people with lower household wealth exhibited more adverse health behaviors, such as smoking, unhealthy diet, and physical inactivity (data not shown), adjustment for those factors did not fully explain the observed association. A recent study from this cohort has shown that stress at work is an important risk factor for the metabolic syndrome (37). Future research exploring the potential biological and psychosocial mechanisms by which inequalities in wealth are associated with the metabolic syndrome may assist in the development of interventions aimed at reducing the burden of this highly prevalent disorder in socially and economically disadvantaged groups.

	APPENDIX

TOP ABSTRACT INTRODUCTION RESEARCH DESIGN AND METHODS-- RESULTS-- CONCLUSIONS-- APPENDIX References

 
For the modified WHO definition of the metabolic syndrome, one of the following must be present:

• Diabetes: fasting glucose 7 mmol/l (126 mg/dl) or postload glucose 11.1 mmol/l (200 mg/dl) or use of antidiabetic medication (oral or insulin)
  
• Impaired glucose tolerance: fasting glucose <7 mmol/l and postload glucose 7.8 mmol/l (140 mg/dl) and <11.1 mmol/l
  
• Impaired fasting glucose: fasting glucose 6.1 mmol/l (110 mg/dl) and <7 mmol/l and postload glucose <7.8 mmol/l
  
• Insulin resistance: HOMA score in the top sex-specific quartile (cutoff in men 0.926278 and cutoff in women 0.8481044), excluding participants with diabetes.
  

• Obesity: waist-to-hip ratio >0.9 in men and >0.85 in women and/or BMI >30 kg/m²
  
• Dyslipidemia: triglycerides 1.7 mmol/l (150 mg/dl) and/or HDL cholesterol <0.9 mmol/l in men (35 mg/dl) or <1.0 mmol/l (39 mg/dl) in women or use of lipid-lowering medication
  
• Hypertension: blood pressure 140/90 mmHg or use of antihypertensive medication.
  

	Acknowledgments

 
The Whitehall II study has been supported by grants from the U.K. Medical Research Council (MRC); British Heart Foundation; Health and Safety Executive; Department of Health; National Heart Lung and Blood Institute (HL36310) and National Institute on Aging (AG13196), National Institutes of Health; Agency for Health Care Policy Research (HS06516); and the John D. and Catherine T. MacArthur Foundation Research Networks on Successful Midlife Development and Socioeconomic Status and Health.

P.P. is supported by a fellowship from the Pan American Health Organization, C.L. is supported by an MRC Research Training Fellowship, J.E.F. is supported by the MRC (G8802774), E.B. is funded by the Higher Education Funding Council for England, and M.M. is supported by an MRC research professorship.

P.P. and C.L. developed the study aim and design, wrote the initial draft and incorporated comments from all coauthors. P.P. undertook the analysis and is guarantor. All authors contributed to interpreting the results and writing the final version.

	Footnotes

 
P.P. and C.L. contributed equally to this article.

A table elsewhere in this issue shows conventional and Système International (SI) units and conversion factors for many substances.

The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C Section 1734 solely to indicate this fact.

Received for publication June 4, 2006. Accepted for publication August 17, 2006.

	References

TOP ABSTRACT INTRODUCTION RESEARCH DESIGN AND METHODS-- RESULTS-- CONCLUSIONS-- APPENDIX References

 

1. Zimmet P, Alberti KG, Shaw J: Global and societal implications of the diabetes epidemic. Nature 414:782–787, 2001[Medline]
   
2. Ford ES, Giles WH, Dietz WH: Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey. JAMA 287:356–359, 2002[Abstract/Free Full Text]
   
3. Balkau B, Charles MA, Drivsholm T, Borch-Johnsen K, Wareham N, Yudkin JS, Morris R, Zavaroni I, van Dam R, Feskins E, Gabriel R, Diet N, Nilsson P, Hedblad B, European Group for the Study of Insulin Resistance: Frequency of the WHO metabolic syndrome in European cohorts, and an alternative definition of an insulin resistance syndrome. Diabetes Metab 28:364–376, 2002[Medline]
   
4. Alberti KG, Zimmet PZ: Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med 15:539–553, 1998[Medline]
   
5. Executive summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). JAMA 285:2486–2497, 2001[Free Full Text]
   
6. Isomaa B, Almgren P, Tuomi T, Forsén B, Lahti K, Nissén M, Taskinen M-R, Groop L: Cardiovascular morbidity and mortality associated with the metabolic syndrome. Diabetes Care 24:683–689, 2001[Abstract/Free Full Text]
   
7. Malik S, Wong ND, Franklin SS, Kamath TV, L’Italien GJ, Pio JR, Williams GR: Impact of the metabolic syndrome on mortality from coronary heart disease, cardiovascular disease, and all causes in United States adults. Circulation 110:1245–1250, 2004
   
8. Stern MP, Williams K, Gonzalez-Villalpando C, Hunt KJ, Haffner SM: Does the metabolic syndrome improve identification of individuals at risk of type 2 diabetes and/or cardiovascular disease? Diabetes Care 27:2676–2681, 2004[Abstract/Free Full Text]
   
9. Sundstrom J, Riserus U, Byberg L, Zethelius B, Lithell H, Lind L: Clinical value of the metabolic syndrome for long term prediction of total and cardiovascular mortality: prospective, population based cohort study. BMJ 332:878–882, 2006[Abstract/Free Full Text]
   
10. Kahn R, Buse J, Ferrannini E, Stern M: The metabolic syndrome: time for a critical appraisal: joint statement from the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care 28:2289–2304, 2005[Abstract/Free Full Text]
    
11. Lidfeldt J, Nyberg P, Nerbrand C, Samsioe G, Schersten B, Agardh CD: Socio-demographic and psychosocial factors are associated with features of the metabolic syndrome: the Women’s Health in the Lund Area (WHILA) study. Diabetes Obes Metab 5:106–112, 2003[Medline]
    
12. Brunner EJ, Marmot MG, Nanchahal K, Shipley MJ, Stansfeld SA, Juneja M, Alberti KG: Social inequality in coronary risk: central obesity and the metabolic syndrome: evidence from the Whitehall II study. Diabetologia 40:1341–1349, 1997[Medline]
    
13. Wamala SP, Lynch J, Horsten M, Mittleman MA, Schenck-Gustafsson K, Orth-Gomer K: Education and the metabolic syndrome in women. Diabetes Care 22:1999–2003, 1999[Abstract/Free Full Text]
    
14. Parker L, Lamont DW, Unwin N, Pearce MS, Bennett SM, Dickinson HO, White M, Mathers JG, Alberti KG, Craft AW: A lifecourse study of risk for hyperinsulinaemia, dyslipidaemia and obesity (the central metabolic syndrome) at age 49–51 years. Diabet Med 20:406–415, 2003[Medline]
    
15. Lawlor DA, Ebrahim S, Davey Smith G: Socioeconomic position in childhood and adulthood and insulin resistance: cross sectional survey using data from British women’s heart and health study. BMJ 325:805, 2002[Abstract/Free Full Text]
    
16. Langenberg C, Kuh D, Wadsworth M, Brunner E, Hardy R: Social circumstances or education? Life course origins of social inequalities in metabolic risk in men and women of a prospective national birth cohort. Am J Public Health. In press
    
17. Banks J, Marmot M, Oldfield Z, Smith JP: Disease and disadvantage in the United States and in England. JAMA 295:2037–2045, 2006[Abstract/Free Full Text]
    
18. Dallongeville J, Cottel D, Ferrières J, Arveiler D, Bingham A, Ruidavets JB, Haas B, Ducimetière P, Amouyel P: Household income is associated with the risk of metabolic syndrome in a sex-specific manner. Diabetes Care 28:409–415, 2005[Abstract/Free Full Text]
    
19. Brewer M, Goodman A, Shaw J, Shephard A: Poverty and Inequality in Britain: 2005. London, Institute for Fiscal Studies, 2005 (Rep. no. 99)
    
20. Shaw M, Davey SG, Dorling D: Health inequalities and New Labour: how the promises compare with real progress. BMJ 330:1016–1021, 2005[Free Full Text]
    
21. Baum F: Wealth and health: the need for more strategic public health research. J Epidemiol Community Health 59:542–545, 2005[Abstract/Free Full Text]
    
22. Marmot MG, Smith GD, Stansfeld S, Patel C, North F, Head J, White I, Burnner E, Feeney A: Health inequalities among British civil servants: the Whitehall II study. Lancet 337:1387–1393, 1991[Medline]
    
23. Dykes J, Brunner EJ, Martikainen PT, Wardle J: Socioeconomic gradient in body size and obesity among women: the role of dietary restraint, disinhibition and hunger in the Whitehall II study. Int J Obes Relat Metab Disord 28:262–268, 2004[Medline]
    
24. Brunner E, Shipley MJ, Blane D, Davey Smith G, Marmot MG: When does cardiovascular risk start? Past and present socioeconomic circumstances and risk factors in adulthood. J Epidemiol Community Health 53:757–764, 1999[Abstract]
    
25. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC: Homeostasis model assessment: insulin resistance and ß-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28:412–419, 1985[Medline]
    
26. Marmot M, Shipley M, Brunner E, Hemingway H: Relative contribution of early life and adult socioeconomic factors to adult morbidity in the Whitehall II study. J Epidemiol Community Health 55:301–307, 2001[Abstract/Free Full Text]
    
27. Kumari M, Marmot M, Rumley A, Lowe G: Social, behavioral, and metabolic determinants of plasma viscosity in the Whitehall II study. Ann Epidemiol 15:398–404, 2005[Medline]
    
28. Rennie KL, McCarthy N, Yazdgerdi S, Marmot M, Brunner E: Association of the metabolic syndrome with both vigorous and moderate physical activity. Int J Epidemiol 32:600–606, 2003[Abstract/Free Full Text]
    
29. Kumari M, Head J, Marmot M: Prospective study of social and other risk factors for incidence of type 2 diabetes in the Whitehall II study. Arch Intern Med 164:1873–1880, 2004[Abstract/Free Full Text]
    
30. Silventoinen K, Pankow J, Jousilahti P, Hu G, Tuomilehto J: Educational inequalities in the metabolic syndrome and coronary heart disease among middle-aged men and women. Int J Epidemiol 34:327–334, 2005[Abstract/Free Full Text]
    
31. Lynch J, Kaplan GA. Socioeconomic position. In Social Epidemiology. Berkman LF, Kawachi I, Eds. London, Oxford University Press, 2000. p. 13–35
    
32. Marmot M. The Missing Men of Russia: Status Syndrome. 1st ed. London, Bloomsbury; 2004. p. 196–221
    
33. Eckel RH, Grundy SM, Zimmet PZ: The metabolic syndrome. Lancet 365:1415–1428, 2005[Medline]
    
34. Lakka HM, Laaksonen DE, Lakka TA, Niskanen LK, Kumpusalo E, Tuomilehto J, Salonen JT: The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men. JAMA 288:2709–2716, 2002[Abstract/Free Full Text]
    
35. Choi SH, Ahn CW, Cha BS, Chung YS, Lee KW, Lee HC, Huh KB, Kim DJ: The prevalence of the metabolic syndrome in Korean adults: comparison of WHO and NCEP criteria. Yonsei Med J 46:198–205, 2005[Medline]
    
36. Martikainen P, Adda J, Ferrie JE, Davey SG, Marmot M: Effects of income and wealth on GHQ depression and poor self rated health in white collar women and men in the Whitehall II study. J Epidemiol Community Health 57:718–723, 2003[Abstract/Free Full Text]
    
37. Chandola T, Brunner E, Marmot M: Chronic stress at work and the metabolic syndrome: prospective study. BMJ 332:521–525, 2006[Abstract/Free Full Text]
    

CiteULike

Del.icio.us

Digg

Reddit

Technorati

This Article Abstract Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Perel, P. Articles by Marmot, M. Search for Related Content PubMed PubMed Citation Articles by Perel, P. Articles by Marmot, M. Social Bookmarking                What's this?