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Implantable Pump Therapy Restores Metabolic Control and Quality of Life in Type 1 Diabetic Patients With Buschke’s Nonsystemic Scleroderma

¹ Department of Endocrinology and Metabolic Diseases, Bocage Hospital, Dijon, France
² Endocrinology Department, Lapeyronie Hospital, Montpellier, France

Address correspondence to Sabine Baillot-Rudoni, MD, Department of Endocrinology and Metabolic Diseases, Bocage Hospital, 21079 Dijon, France. E-mail: sabine.rudoni{at}dijon.fr

Buschke’s nonsystemic scleroderma is an uncommon dermatosis characterized by thickened and indurate skin of unknown origin, mostly affecting upper parts of the body but also the abdominal area. While diabetes is rarely associated, subcutaneous insulin treatment may be hardly feasible and effective because of incomplete absorption of insulin (1).

After approval of our institutional ethical committees, four type 1 diabetic patients (one male and three female subjects) affected by this condition received Medtronic MiniMed implantable pumps (Northridge, CA) for intraperitoneal insulin delivery (2) between 1994 and 2004. The patients, aged 45.2 ± 2.9 years, had a mean duration of diabetes of 33.5 ± 1.3 years, including multiple microvascular complications. Biopsies of the affected skin, performed in three patients, confirmed expanded dermis with enlarged collagen bundles and, in one case, visible mucin. None had evidence of systemic sclerosis by biopsy and other investigations at baseline or during follow-up. Skin status was clinically assessed on a yearly basis, diabetes complications surveyed as required, and HbA_1c (A1C) measured using a high-performance liquid chromatography method (normal values <5.6%) on a quarterly basis.

From implantation time, improvement of glucose control was sustained as shown by mean yearly A1C moving from 9.3 ± 0.7% (baseline) to 7.9 ± 1.3% (2005). Microvascular complications remained stable or decreased. All patients experienced a dramatic decrease of skin induration as early as a few months after implantation. We found clinical improvement of the skin aspect in terms of redness, swelling, and induration, even if we did not have tools at our disposal to measure skin elasticity.

Several published case reports describe either poorly effective therapeutic options for Buschke’s scleroderma (3,4) or the effective, albeit rather extreme, radiation therapy (5). Poor glycemic control may play a role in worsening of the skin condition, resulting in a vicious cycle of worsening control and worsening disease driven by poor absorption of insulin (6). Although not documented by pathological or biochemical skin analyses, our findings support previous hypotheses that glucose excess causes impairment through increased glycation alterations of tissue collagen, which are involved in Buschke’s scleroderma, and that this process can be reversed with improved glucose control. We suggest implantable pump therapy as an option in patients with type 1 diabetes affected by this uncommon skin condition when optimized subcutaneous insulin treatment fails to achieve acceptable blood glucose control.

References

1. Jabbour SA: Cutaneous manifestations of endocrine disorders: a guide for dermatologists. Am J Clin Dermatol 4:315–331, 2003[Medline]
   
2. Broussolle C, Jeandidier N, Hanaire-Broutin H, the EVADIAC Study Group: French multicenter experience of implantable insulin pumps. Lancet 343:514–515, 1994[Medline]
   
3. Seyger MM, Van Den Hoogen FH, De Mare S, Van Haelst U, De Jong EM: A patient with a severe scleroedema diabeticorum, partially responding to low-dose methotrexate. Dermatology 198:177–179, 1999[Medline]
   
4. Krasagakis K, Hettmannsperger U, Trautmann C, Tebbe B, Garbe C: Persistent scleredema of Buschke in a diabetic: improvement with high-dose penicillin (Letter). Br J Dermatol 134:597–598, 1996[Medline]
   
5. Bowen AR, Smith L, Zone JJ: Scleredema adultorum of Buschke treated with radiation. Arch Dermatol 139:780–784, 2003[Abstract/Free Full Text]
   
6. Buckingham BA, Uitto J, Sandborg C, Keens T, Roe T, Costin G, Kaufman F, Bernstein B, Landing B, Castellano A: Scleroderma-like changes in insulin-dependent diabetes mellitus: clinical and biochemical studies. Diabetes Care 7:163–169, 1984[Abstract]
   

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This Article Extract Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Baillot-Rudoni, S. Search for Related Content PubMed PubMed Citation Articles by Baillot-Rudoni, S. Social Bookmarking                What's this?