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Standards of Medical Care in Diabetes–2006

Abbreviations: ABI, ankle-brachial index • AMI, acute myocatdial infarction • ARB, angiotensin receptor blocker • CAD, coronary artery disease • CBG, capillary blood glucose • CHD, coronary heart disease • CHF, congestive heart failure • CKD, chronic kidney disease • CVD, cardiovascular disease • DCCB, dihydropyridine calcium channel blocker • DCCT, Diabetes Control and Complications Trial • DKA, diabetic ketoacidosis • DMMP, diabetes medical management plan • DPN, distal symmetric polyneuropathy • DPP, Diabetes Prevention Program • DRI, dietary reference intake • DRS, Diabetic Retinopathy Study • DSME, diabetes self-management education • DSMT, diabetes self-management training • ECG, electrocardiogram • ESRD, end-stage renal disease • ETDRS, Early Treatment Diabetic Retinopathy Study • FDA, Food and Drug Administration • FPG, fasting plasma glucose • GDM, gestational diabetes mellitus • GFR, glomerular filtration rate • HRC, high-risk characteristic • ICU, intensive care unit • IFG, impaired fasting glucose • IGT, impaired glucose tolerance • MNT, medical nutrition therapy • NPDR, nonproliferative diabetic retinopathy • OGTT, oral glucose tolerance test • PAD, peripheral arterial disease • PDR, proliferative diabetic retinopathy • PPG, postprandial plasma glucose • RDA, recommended dietary allowance • SMBG, self-monitoring of blood glucose • TZD, thiazolidinedione • UKPDS, U.K. Prospective Diabetes Study

	CONTENTS

TOP CONTENTS I. CLASSIFICATION AND DIAGNOSIS II. SCREENING FOR DIABETES III. DETECTION AND DIAGNOSIS... IV. PREVENTION/DELAY OF TYPE... V. DIABETES CARE E. DSME F. Physical activity G. Psychosocial assessment and... H. Referral for diabetes... I. Intercurrent illness J. Hypoglycemia K. Immunization VI. PREVENTION AND MANAGEMENT... E. Foot care VII. DIABETES CARE IN... VIII. DIABETES CARE IN... B. Diabetes care in... C. Diabetes care at... D. Diabetes management in... IX. HYPOGLYCEMIA AND... X. THIRD-PARTY REIMBURSEMENT FOR... References

 
I. CLASSIFICATION AND DIAGNOSIS, p. S4

A. Classification

B. Diagnosis

II. SCREENING FOR DIABETES, p. S5

III. DETECTION AND DIAGNOSIS OF GESTATIONAL DIABETES MELLITUS, p. S7

IV. PREVENTION/DELAY OF TYPE 2 DIABETES, p. S7

V. DIABETES CARE, p. S8

A. Initial evaluation

B. Management

C. Glycemic control

1. Assessment of glycemic control

a. Self-monitoring of blood glucose

b. A1C

2. Glycemic goals

D. Medical nutrition therapy

E. Diabetes self-management education

F. Physical activity

G. Psychosocial assessment and care

H. Referral for diabetes management

I. Intercurrent illness

J. Hypoglycemia

K. Immunization

VI. PREVENTION AND MANAGEMENT OF DIABETES COMPLICATIONS, p. S17

A. Cardiovascular disease

1. Hypertension/blood pressure control

2. Dyslipidemia/lipid management

3. Antiplatelet agents

4. Smoking cessation

5. Coronary heart disease screening and treatment

B. Nephropathy screening and treatment

C. Retinopathy screening and treatment

D. Neuropathy screening and treatment

E. Foot care

VII. DIABETES CARE IN SPECIFIC POPULATIONS, p. S26

A. Children and adolescents

B. Preconception care

C. Older individuals

VIII. DIABETES CARE IN SPECIFIC SETTINGS, p. S29

A. Diabetes care in the hospital

B. Diabetes care in the school and day care setting

C. Diabetes care at diabetes camps

D. Diabetes management in correctional institutions

IX. HYPOGLYCEMIA AND EMPLOYMENT/LICENSURE, p. S34

X. THIRD-PARTY REIMBURSEMENT FOR DIABETES CARE, SELF-MANAGEMENT EDUCATION, AND SUPPLIES, p. S34

XI. STRATEGIES FOR IMPROVING DIABETES CARE, p. S34

Diabetes is a chronic illness that requires continuing medical care and patient self-management education to prevent acute complications and to reduce the risk of long-term complications. Diabetes care is complex and requires that many issues, beyond glycemic control, be addressed. A large body of evidence exists that supports a range of interventions to improve diabetes outcomes.

These standards of care are intended to provide clinicians, patients, researchers, payors, and other interested individuals with the components of diabetes care, treatment goals, and tools to evaluate the quality of care. While individual preferences, comorbidities, and other patient factors may require modification of goals, targets that are desirable for most patients with diabetes are provided. These standards are not intended to preclude more extensive evaluation and management of the patient by other specialists as needed. For more detailed information, refer to refs. 1–3.

The recommendations included are diagnostic and therapeutic actions that are known or believed to favorably affect health outcomes of patients with diabetes. A grading system (Table 1), developed by the American Diabetes Association (ADA) and modeled after existing methods, was utilized to clarify and codify the evidence that forms the basis for the recommendations. The level of evidence that supports each recommendation is listed after each recommendation using the letters A, B, C, or E.

	I. CLASSIFICATION AND DIAGNOSIS

TOP CONTENTS I. CLASSIFICATION AND DIAGNOSIS II. SCREENING FOR DIABETES III. DETECTION AND DIAGNOSIS... IV. PREVENTION/DELAY OF TYPE... V. DIABETES CARE E. DSME F. Physical activity G. Psychosocial assessment and... H. Referral for diabetes... I. Intercurrent illness J. Hypoglycemia K. Immunization VI. PREVENTION AND MANAGEMENT... E. Foot care VII. DIABETES CARE IN... VIII. DIABETES CARE IN... B. Diabetes care in... C. Diabetes care at... D. Diabetes management in... IX. HYPOGLYCEMIA AND... X. THIRD-PARTY REIMBURSEMENT FOR... References

• Type 1 diabetes (results from ß-cell destruction, usually leading to absolute insulin deficiency).
  
• Type 2 diabetes (results from a progressive insulin secretory defect on the background of insulin resistance).
  
• Other specific types of diabetes due to other causes, e.g., genetic defects in ß-cell function, genetic defects in insulin action, diseases of the exocrine pancreas (such as cystic fibrosis), and drug or chemical induced (such as in the treatment of AIDS or after organ transplantation).
  
• Gestational diabetes mellitus (GDM) (diagnosed during pregnancy).
  

B. Diagnosis
Recommendations

• The FPG is the preferred test to diagnose diabetes in children and nonpregnant adults. (E)
  
• The use of the A1C for the diagnosis of diabetes is not recommended at this time. (E)
  

Criteria for the diagnosis of diabetes in nonpregnant adults are shown in Table 2. Three ways to diagnose diabetes are available, and each must be confirmed on a subsequent day unless unequivocal symptoms of hyperglycemia are present. Although the 75-g oral glucose tolerance test (OGTT) is more sensitive and modestly more specific than fasting plasma glucose (FPG) to diagnose diabetes, it is poorly reproducible and rarely performed in practice. Because of ease of use, acceptability to patients, and lower cost, the FPG is the preferred diagnostic test. It should be noted that the vast majority of people who meet diagnostic criteria for diabetes by OGTT, but not by FPG, will have an A1C value <7.0%. The use of the A1C for the diagnosis of diabetes is not recommended at this time.

• IFG = FPG 100 mg/dl (5.6 mmol/l) to 125 mg/dl (6.9 mmol/l)
  
• IGT = 2-h plasma glucose 140 mg/dl (7.8 mmol/l) to 199 mg/dl (11.0 mmol/l)
  

Recently, IFG and IGT have been officially termed "pre-diabetes." Both categories, IFG and IGT, are risk factors for future diabetes and cardiovascular disease (CVD).

In the absence of unequivocal hyperglycemia, these criteria should be confirmed by repeat testing on a different day. The OGTT is not recommended for routine clinical use but may be required in the evaluation of patients with IFG (see text) or when diabetes is still suspected despite a normal FPG, as with the postpartum evaluation of women with GDM.

	II. SCREENING FOR DIABETES

TOP CONTENTS I. CLASSIFICATION AND DIAGNOSIS II. SCREENING FOR DIABETES III. DETECTION AND DIAGNOSIS... IV. PREVENTION/DELAY OF TYPE... V. DIABETES CARE E. DSME F. Physical activity G. Psychosocial assessment and... H. Referral for diabetes... I. Intercurrent illness J. Hypoglycemia K. Immunization VI. PREVENTION AND MANAGEMENT... E. Foot care VII. DIABETES CARE IN... VIII. DIABETES CARE IN... B. Diabetes care in... C. Diabetes care at... D. Diabetes management in... IX. HYPOGLYCEMIA AND... X. THIRD-PARTY REIMBURSEMENT FOR... References

 
Recommendations

• Screening to detect pre-diabetes (IFG or IGT) and diabetes should be considered in individuals 45 years of age, particularly in those with a BMI 25 kg/m². Screening should also be considered for people who are <45 years of age and are overweight if they have another risk factor for diabetes (Table 3). Repeat testing should be carried out at 3-year intervals. (E)
  
• Screen for pre-diabetes and diabetes in high-risk, asymptomatic, undiagnosed adults and children within the health care setting. (E)
  
• To screen for diabetes/pre-diabetes, either an FPG test or 2-h OGTT (75-g glucose load) or both are appropriate. (B)
  
• An OGTT may be considered in patients with IFG to better define the risk of diabetes. (E)
  

Type 1 diabetes
Generally, people with type 1 diabetes present with acute symptoms of diabetes and markedly elevated blood glucose levels. Because of the acute onset of symptoms, most cases of type 1 diabetes are detected soon after symptoms develop. Widespread clinical testing of asymptomatic individuals for the presence of autoantibodies related to type 1 diabetes cannot be recommended at this time as a means to identify individuals at risk. Reasons for this include the following: 1) cutoff values for some of the immune marker assays have not been completely established in clinical settings; 2) there is no consensus as to what action should be taken when a positive autoantibody test result is obtained; and 3) because the incidence of type 1 diabetes is low, testing of healthy children will identify only a very small number (<0.5%) who at that moment may be "pre-diabetic." Clinical studies are being conducted to test various methods of preventing type 1 diabetes in high-risk individuals (e.g., siblings of type 1 diabetic patients). These studies may uncover an effective means of preventing type 1 diabetes, in which case targeted screening may be appropriate in the future.

Type 2 diabetes
Type 2 diabetes is frequently not diagnosed until complications appear, and approximately one-third of all people with diabetes may be undiagnosed. Individuals at high risk should be screened for diabetes and pre-diabetes. Criteria for testing for diabetes in asymptomatic, undiagnosed adults are listed in Table 3. The effectiveness of early diagnosis through screening of asymptomatic individuals has not been determined (6).

Screening should be carried out within the health care setting. Either an FPG test or 2-h OGTT (75-g glucose load) is appropriate. The 2-h OGTT identifies people with IGT, and thus, more people who are at increased risk for the development of diabetes and CVD. It should be noted that the two tests do not necessarily detect the same individuals (7). It is important to recognize that although the efficacy of interventions for primary prevention of type 2 diabetes have been demonstrated among individuals with IGT (8–10), such data among individuals with IFG (who do not also have IGT) are not available. The FPG test is more convenient to patients, more reproducible, less costly, and easier to administer than the 2-h OGTT (4,5). Therefore, the recommended initial screening test for nonpregnant adults is the FPG. An OGTT may be considered in patients with IFG to better define the risk of diabetes.

The incidence of type 2 diabetes in children and adolescents has increased dramatically in the last decade. Consistent with screening recommendations for adults, only children and youth at increased risk for the presence or the development of type 2 diabetes should be tested (11) (Table 4).

On the basis of expert opinion, screening should be considered by health care providers at 3-year intervals beginning at age 45, particularly in those with BMI 25 kg/m². The rationale for this interval is that false negatives will be repeated before substantial time elapses, and there is little likelihood of an individual developing any of the complications of diabetes to a significant degree within 3 years of a negative screening test result. Testing should be considered at a younger age or be carried out more frequently in individuals who are overweight and have one or more of the other risk factors for type 2 diabetes.

	III. DETECTION AND DIAGNOSIS OF GDM

TOP CONTENTS I. CLASSIFICATION AND DIAGNOSIS II. SCREENING FOR DIABETES III. DETECTION AND DIAGNOSIS... IV. PREVENTION/DELAY OF TYPE... V. DIABETES CARE E. DSME F. Physical activity G. Psychosocial assessment and... H. Referral for diabetes... I. Intercurrent illness J. Hypoglycemia K. Immunization VI. PREVENTION AND MANAGEMENT... E. Foot care VII. DIABETES CARE IN... VIII. DIABETES CARE IN... B. Diabetes care in... C. Diabetes care at... D. Diabetes management in... IX. HYPOGLYCEMIA AND... X. THIRD-PARTY REIMBURSEMENT FOR... References

 
Recommendations

• Screen for diabetes in pregnancy using risk factor analysis and, if appropriate, use of an OGTT. (C)
  
• Women with GDM should be screened for diabetes 6–12 weeks postpartum and should be followed up with subsequent screening for the development of diabetes or pre-diabetes. (E)
  

Risk assessment for GDM should be undertaken at the first prenatal visit. Women with clinical characteristics consistent with a high risk for GDM (those with marked obesity, personal history of GDM, glycosuria, or a strong family history of diabetes) should undergo glucose testing as soon as possible (14). An FPG 126 mg/dl or a casual plasma glucose 200 mg/dl meets the threshold for the diagnosis of diabetes and needs to be confirmed on a subsequent day unless unequivocal symptoms of hyperglycemia are present. High-risk women not found to have GDM at the initial screening and average-risk women should be tested between 24 and 28 weeks of gestation. Testing should follow one of two approaches:

• One-step approach: perform a diagnostic 100-g OGTT
  
• Two-step approach: perform an initial screening by measuring the plasma or serum glucose concentration 1 h after a 50-g oral glucose load (glucose challenge test) and perform a diagnostic 100-g OGTT on that subset of women exceeding the glucose threshold value on the glucose challenge test. When the two-step approach is used, a glucose threshold value 140 mg/dl identifies 80% of women with GDM, and the yield is further increased to 90% by using a cutoff of 130 mg/dl.
  

Diagnostic criteria for the 100-g OGTT are as follows: 95 mg/dl fasting, 180 mg/dl at 1 h, 155 mg/dl at 2 h, and 140 mg/dl at 3 h. Two or more of the plasma glucose values must be met or exceeded for a positive diagnosis. The test should be done in the morning after an overnight fast of 8–14 h. The diagnosis can be made using a 75-g glucose load, but that test is not as well validated for detection of at-risk infants or mothers as the 100-g OGTT.

Low-risk status requires no glucose testing, but this category is limited to those women meeting all of the following characteristics:

• Age <25 years.
  
• Weight normal before pregnancy.
  
• Member of an ethnic group with a low prevalence of GDM.
  
• No known diabetes in first-degree relatives.
  
• No history of abnormal glucose tolerance.
  
• No history of poor obstetric outcome.
  

	IV. PREVENTION/DELAY OF TYPE 2 DIABETES

TOP CONTENTS I. CLASSIFICATION AND DIAGNOSIS II. SCREENING FOR DIABETES III. DETECTION AND DIAGNOSIS... IV. PREVENTION/DELAY OF TYPE... V. DIABETES CARE E. DSME F. Physical activity G. Psychosocial assessment and... H. Referral for diabetes... I. Intercurrent illness J. Hypoglycemia K. Immunization VI. PREVENTION AND MANAGEMENT... E. Foot care VII. DIABETES CARE IN... VIII. DIABETES CARE IN... B. Diabetes care in... C. Diabetes care at... D. Diabetes management in... IX. HYPOGLYCEMIA AND... X. THIRD-PARTY REIMBURSEMENT FOR... References

 
Recommendations

• Individuals at high risk for developing diabetes need to become aware of the benefits of modest weight loss and participating in regular physical activity. (A)
  
• Patients with IGT should be given counseling on weight loss as well as instruction for increasing physical activity. (A)
  
• Patients with IFG should be given counseling on weight loss as well as instruction for increasing physical activity. (E)
  
• Follow-up counseling appears important for success. (B)
  
• Monitoring for the development of diabetes in those with pre-diabetes should be performed every 1–2 years. (E)
  
• Close attention should be given to, and appropriate treatment given for, other CVD risk factors (e.g., tobacco use, hypertension, dyslipidemia). (A)
  
• Drug therapy should not be routinely used to prevent diabetes until more information is known about its cost-effectiveness. (E)
  

Studies have been initiated in the last decade to determine the feasibility and benefit of various strategies to prevent or delay the onset of type 2 diabetes. Five well-designed randomized controlled trials have been reported (8–10,15,16). The strategies shown to be effective in preventing diabetes relied on lifestyle modification or glucose-lowering drugs that have been approved for treating diabetes.

In the Finnish study (9), middle-aged obese subjects with IGT were randomized to receive either brief diet and exercise counseling (control group) or intensive individualized instruction on weight reduction, food intake, and guidance on increasing physical activity (intervention group). After an average follow-up of 3.2 years, there was a 58% relative reduction in the incidence of diabetes in the intervention group compared with the control subjects.

In the Diabetes Prevention Program (DPP) (8), enrolled subjects were slightly younger and more obese but had nearly identical glucose intolerance compared with subjects in the Finnish study. About 45% of the participants were from minority groups (e.g., African American, Hispanic), and 20% were 60 years of age. Subjects were randomized to one of three intervention groups, which included the intensive nutrition and exercise counseling ("lifestyle") group or either of two masked medication treatment groups: the biguanide metformin group or the placebo group. The latter interventions were combined with standard diet and exercise recommendations. After an average follow-up of 2.8 years, a 58% relative reduction in the progression to diabetes was observed in the lifestyle group and a 31% relative reduction in the progression of diabetes was observed in the metformin group compared with control subjects. On average, 50% of the lifestyle group achieved the goal of 7% weight reduction and 74% maintained at least 150 min/week of moderately intense activity. In the troglitazone arm of the DPP (discontinued after a mean of 0.9 years when the drug was withdrawn from the market), troglitazone markedly reduced the incidence of diabetes during the period the drug was given (16a).

In the Da Qing Study (10), men and women from health care clinics in the city of Da Qing, China, were screened with OGTT, and those with IGT were randomized by clinic to a control group or to one of three active treatment groups: diet only, exercise only, or diet plus exercise. Subjects were reexamined biannually, and after an average of 6 years’ follow-up, the diet, exercise, and diet plus exercise interventions were associated with 31, 46, and 42% reductions in risk of developing type 2 diabetes, respectively.

Three other studies, each using a different class of glucose-lowering agent, have shown a reduction in progression to diabetes with pharmacological intervention. In the Troglitazone in Prevention of Diabetes (TRIPOD) study (15), Hispanic women with previous GDM were randomized to receive either placebo or troglitazone (a drug now withdrawn from commercial sale in the U.S. but belonging to the thiazolidinedione [TZD] class). After a median follow-up of 30 months, troglitazone treatment was associated with a 56% relative reduction in progression to diabetes. In the STOP-IDDM trial (16), participants with IGT were randomized in a double-blind fashion to receive either the -glucosidase inhibitor acarbose or a placebo. After a mean follow-up of 3.3 years, a 25% relative risk reduction in progression to diabetes, based on one OGTT, was observed in the acarbose-treated group compared with the placebo group. If this diagnosis was confirmed by a second OGTT, a 36% relative risk reduction was observed in the acarbose group compared with the placebo group.

Finally, in the XENical in the prevention of Diabetes in Obese Subjects (XENDOS) study, orlistat was examined for its ability to delay type 2 diabetes when added to lifestyle change in a group with BMI 30 kg/m² with or without IGT. After 4 years of treatment, the effect of orlistat addition corresponded to a 45% risk reduction in the IGT group, with no effect observed in those without IGT (16b).

Our knowledge of the early stages of hyperglycemia that portend the diagnosis of diabetes, and the recent success of major intervention trials, clearly show that individuals at high risk can be identified and diabetes delayed, if not prevented. The cost-effectiveness of intervention strategies is unclear, but the huge burden resulting from the complications of diabetes and the potential ancillary benefits of some of the interventions suggest that an effort to prevent diabetes is worthwhile.

Lifestyle modification
In well-controlled studies that included a lifestyle intervention arm, substantial efforts were necessary to achieve only modest changes in weight and exercise, but those changes were sufficient to achieve an important reduction in the incidence of diabetes. In the Finnish Diabetes Prevention Study, weight loss averaged 9.2 lb at 1 year, 7.7 lb after 2 years, and 4.6 lb after 5 years (9); "moderate exercise," such as brisk walking, for 30 min/day was suggested. In the Finnish study, there was a direct relationship between adherence with the lifestyle intervention and the reduced incidence of diabetes.

In the DPP (8), the lifestyle group lost 12 lb at 2 years and 9 lb at 3 years (mean weight loss for the study duration was 12 lb or 6% of initial body weight). In both of these studies, most of the participants were obese (BMI >30 kg/m²).

A low-fat (<25% fat) intake was recommended; if reducing fat did not produce weight loss to goal, calorie restriction was also recommended. Participants weighing 120–174 lb (54–78 kg) at baseline were instructed to follow a 1,200-kcal/day diet (33 g fat), those 175–219 lb (79–99 kg) were instructed to follow a 1,500-kcal/day diet (42 g fat), those 220–249 lb (100–113 kg) were instructed to follow an 1,800-kcal/day diet (50 g fat), and those >250 lb (114 kg) were instructed to follow a 2,000-kcal/day diet (55 g fat).

Pharmacological interventions
Three diabetes prevention trials used pharmacological therapy, and all have reported a significant lowering of the incidence of diabetes. The biguanide metformin reduced the risk of diabetes by 31% in the DPP (8), the -glucosidase inhibitor acarbose reduced the risk by 32% in the STOP-IDDM trial (16), and the TZD troglitazone reduced the risk by 56% in the TRIPOD study (15).

In the DPP, metformin was about half as effective as diet and exercise in delaying the onset of diabetes overall, but it was nearly ineffective in older individuals (60 years of age) or in those who were less overweight (BMI <30 kg/m²). Conversely, metformin was as effective as lifestyle modification in individuals aged 24–44 years or in those with a BMI 35 kg/m². Thus, the population of people in whom treatment with metformin has equal benefit to that of a lifestyle intervention is only a small subset of those who are likely to have pre-diabetes (IFG or IGT).

There are also data to suggest that blockade of the renin-angiotensin system (17) may lower the risk of developing diabetes, but more studies are necessary before these drugs can be recommended for preventing diabetes.

Lifestyle or medication?
The DPP is the only study in which a comparison of the two was made, and lifestyle modification was nearly twice as effective in preventing diabetes (58 vs. 31% relative reductions, respectively). The greater benefit of weight loss and physical activity strongly suggests that lifestyle modification should be the first choice to prevent or delay diabetes. Modest weight loss (5–10% of body weight) and modest physical activity (30 min daily) are the recommended goals. Because this intervention not only has been shown to prevent or delay diabetes, but also has a variety of other benefits, health care providers should urge all overweight or sedentary individuals to adopt these changes, and such recommendations should be made at every opportunity.

When all factors are considered, there is insufficient evidence to support the use of drug therapy as a substitute for, or routinely used in addition to, lifestyle modification to prevent diabetes. Public health messages, health care professionals, and health care systems should all encourage behavior changes to achieve a healthy lifestyle. Further research is necessary to understand better how to facilitate effective and efficient programs for the primary prevention of type 2 diabetes.

	V. DIABETES CARE

TOP CONTENTS I. CLASSIFICATION AND DIAGNOSIS II. SCREENING FOR DIABETES III. DETECTION AND DIAGNOSIS... IV. PREVENTION/DELAY OF TYPE... V. DIABETES CARE E. DSME F. Physical activity G. Psychosocial assessment and... H. Referral for diabetes... I. Intercurrent illness J. Hypoglycemia K. Immunization VI. PREVENTION AND MANAGEMENT... E. Foot care VII. DIABETES CARE IN... VIII. DIABETES CARE IN... B. Diabetes care in... C. Diabetes care at... D. Diabetes management in... IX. HYPOGLYCEMIA AND... X. THIRD-PARTY REIMBURSEMENT FOR... References

 
A. Initial evaluation
A complete medical evaluation should be performed to classify the patient, detect the presence or absence of diabetes complications, assist in formulating a management plan, and provide a basis for continuing care. If the diagnosis of diabetes has already been made, the evaluation should review the previous treatment and the past and present degrees of glycemic control. Laboratory tests appropriate to the evaluation of each patient’s general medical condition should be performed. A focus on the components of comprehensive care (Table 5) will assist the health care team to ensure optimal management of the patient with diabetes.

The management plan should be formulated as an individualized therapeutic alliance among the patient and family, the physician, and other members of the health care team. Any plan should recognize diabetes self-management education (DSME) as an integral component of care. In developing the plan, consideration should be given to the patient’s age, school or work schedule and conditions, physical activity, eating patterns, social situation and personality, cultural factors, and presence of complications of diabetes or other medical conditions. A variety of strategies and techniques should be used to provide adequate education and development of problem-solving skills in the various aspects of diabetes management. Implementation of the management plan requires that each aspect is understood and agreed on by the patient and the care providers and that the goals and treatment plan are reasonable.

C. Glycemic control
1. Assessment of glycemic control.
Techniques are available for health providers and patients to assess the effectiveness of the management plan on glycemic control.

a. Self-monitoring of blood glucose
   Recommendations

• Clinical trials using insulin that have demonstrated the value of tight glycemic control have used self-monitoring of blood glucose (SMBG) as an integral part of the management strategy. (A)
  
• SMBG should be carried out three or more times daily for patients using multiple insulin injections. (A)
  
• For patients using less frequent insulin injections or oral agents or medical nutrition therapy (MNT) alone, SMBG is useful in achieving glycemic goals. (E)
  
• To achieve postprandial glucose targets, postprandial SMBG may be appropriate. (E)
  
• Instruct the patient in SMBG and routinely evaluate the patient’s technique and ability to use data to adjust therapy. (E)
  

The ADA’s consensus statements on SMBG provide a comprehensive review of the subject (18,19). Major clinical trials assessing the impact of glycemic control on diabetes complications have included SMBG as part of multifactorial interventions, suggesting that SMBG is a component of effective therapy. SMBG allows patients to evaluate their individual response to therapy and assess whether glycemic targets are being achieved. Results of SMBG can be useful in preventing hypoglycemia and adjusting medications, MNT, and physical activity.

The frequency and timing of SMBG should be dictated by the particular needs and goals of the patients. Daily SMBG is especially important for patients treated with insulin to monitor for and prevent asymptomatic hypoglycemia and hyperglycemia. For most patients with type 1 diabetes and pregnant women taking insulin, SMBG is recommended three or more times daily. The optimal frequency and timing of SMBG for patients with type 2 diabetes on oral agent therapy is not known but should be sufficient to facilitate reaching glucose goals. Patients with type 2 diabetes on insulin typically need to perform SMBG more frequently than those not using insulin. When adding to or modifying therapy, type 1 and type 2 diabetic patients should test more often than usual. The role of SMBG in stable diet-treated patients with type 2 diabetes is not known.

Because the accuracy of SMBG is instrument and user dependent (20), it is important for health care providers to evaluate each patient’s monitoring technique, both initially and at regular intervals thereafter. In addition, optimal use of SMBG requires proper interpretation of the data. Patients should be taught how to use the data to adjust food intake, exercise, or pharmacological therapy to achieve specific glycemic goals. Health professionals should evaluate at regular intervals the patient’s ability to use SMBG data to guide treatment.

b. A1C
Recommendations

• Perform the A1C test at least two times a year in patients who are meeting treatment goals (and who have stable glycemic control). (E)
  
• Perform the A1C test quarterly in patients whose therapy has changed or who are not meeting glycemic goals. (E)
  
• Use of point-of-care testing for A1C allows for timely decisions on therapy changes, when needed. (E)
  

By performing an A1C test, health providers can measure a patient’s average glycemia over the preceding 2–3 months (20) and, thus, assess treatment efficacy. A1C testing should be performed routinely in all patients with diabetes, first to document the degree of glycemic control at initial assessment and then as part of continuing care. Since the A1C test reflects mean glycemia over the preceding 2–3 months, measurement approximately every 3 months is required to determine whether a patient’s metabolic control has been reached and maintained within the target range. Thus, regular performance of the A1C test permits detection of departures from the target (Table 6) in a timely fashion. For any individual patient, the frequency of A1C testing should be dependent on the clinical situation, the treatment regimen used, and the judgment of the clinician.

Glycemic control is best judged by the combination of the results of the patient’s SMBG testing (as performed) and the current A1C result. The A1C should be used not only to assess the patient’s control over the preceding 2–3 months but also as a check on the accuracy of the meter (or the patient’s self-reported results) and the adequacy of the SMBG testing schedule. Table 7 contains the correlation between A1C levels and mean plasma glucose levels based on data from the Diabetes Control and Complications Trial (DCCT) (23).

• Lowering A1C has been associated with a reduction of microvascular and neuropathic complications of diabetes. (A)
  
• The A1C goal for patients in general is an A1C goal of <7%. (B)
  
• The A1C goal for the individual patient is an A1C as close to normal (<6%) as possible without significant hypoglycemia. (E)
  
• Less stringent treatment goals may be appropriate for patients with a history of severe hypoglycemia, patients with limited life expectancies, very young children or older adults, and individuals with comorbid conditions. (E)
  
• Aggressive glycemic management with insulin may reduce morbidity in patients with severe acute illness, perioperatively, following myocardial infarction, and in pregnancy. (B)
  

Glycemic control is fundamental to the management of diabetes. The goal of therapy is to acheive an A1C as close to normal as possible (representing normal fasting and postprandial glucose concentrations) in the absence of hypoglycemia. However, this goal is difficult to achieve with present therapies (24). Prospective randomized clinical trials such as the DCCT (25) and the U.K. Prospective Diabetes Study (UKPDS) (26,27) have shown that improved glycemic control is associated with sustained decreased rates of retinopathy, nephropathy, and neuropathy (28). In these trials, treatment regimens that reduced average A1C to 7% (1% above the upper limits of normal) were associated with fewer long-term microvascular complications; however, intensive control was found to increase the risk of severe hypoglycemia and weight gain (29,30). The potential of intensive glycemic control to reduce CVD is supported by epidemiological studies (25–30) and a recent meta-analysis (31), but this potential benefit on CVD events has not yet been demonstrated in a randomized clinical trial.

Recommended glycemic goals for nonpregnant individuals are shown in Table 6. A major limitation to the available data is that they do not identify the optimum level of control for particular patients, as there are individual differences in the risks of hypoglycemia, weight gain, and other adverse effects. Furthermore, with multifactorial interventions, it is unclear how different components (e.g., educational interventions, glycemic targets, lifestyle changes, pharmacological agents) contribute to the reduction of complications. There are no clinical trial data available for the effects of glycemic control in patients with advanced complications, the elderly (65 years of age), or young children (<13 years of age). Less stringent treatment goals may be appropriate for patients with limited life expectancies, in the very young or older adults, and in individuals with comorbid conditions. Severe or frequent hypoglycemia is an indication for the modification of treatment regimens, including setting higher glycemic goals.

More stringent goals (i.e., a normal A1C, <6%) should be considered in individual patients based on epidemiological analyses suggesting that there is no lower limit of A1C at which further lowering does not reduce the risk of complications, at the risk of increased hypoglycemia (particularly in those with type 1 diabetes). However, the absolute risks and benefits of lower targets are unknown. The risks and benefits of an A1C goal of <6% are currently being tested in an ongoing study (ACCORD [Action to Control Cardiovascular Risk in Diabetes]) in type 2 diabetes.

Elevated postchallenge (2-h OGTT) glucose values have been associated with increased cardiovascular risk independent of FPG in some epidemiological studies. Postprandial plasma glucose (PPG) levels >140 mg/dl are unusual in nondiabetic individuals, although large evening meals can be followed by plasma glucose values up to 180 mg/dl. There are now pharmacological agents that primarily modify PPG and thereby reduce A1C in parallel. Thus, in individuals who have premeal glucose values within target but who are not meeting A1C targets, consideration of monitoring PPG 1–2 h after the start of the meal and treatment aimed at reducing PPG values <180 mg/dl may lower A1C. However, it should be noted that the effect of these approaches on micro- or macrovascular complications has not been studied (32).

As regards goals for glycemic control for women with GDM, recommendations from the Fourth International Workshop-Conference on Gestational Diabetes suggest lowering maternal capillary blood glucose concentrations to 95 mg/dl (5.3 mmol/l) fasting, 140 mg/dl (7.8 mmol/l) at 1 h, and/or 120 mg/dl (6.7 mmol/l) at 2 h after the meal (32a). For further information on GDM, refer to the ADA position statement (14). For information on glycemic control during pregnancy in women with preexisting diabetes, refer to ref. 33.

D. MNT
Recommendations

• People with diabetes should receive individualized MNT as needed to achieve treatment goals, preferably provided by a registered dietitian familiar with the components of diabetes MNT. (B)
  
• Both the amount (grams) of carbohydrate as well as the type of carbohydrate in a food influence blood glucose level. Monitoring total grams of carbohydrate, whether by use of exchanges or carbohydrate counting, remains a key strategy in achieving glycemic control. (A)
  
• The use of the glycemic index/glycemic load may provide an additional benefit over that observed when total carbohydrate is considered alone. (B)
  
• Low-carbohydrate diets (restricting total carbohydrate to <130 g/day) are not recommended in the management of diabetes. (E)
  
• To reduce the risk of nephropathy, protein intake should be limited to the recommended dietary allowance (RDA) (0.8 g/kg) in those with any degree of CKD. (B)
  
• Saturated fat intake should be <7% of total calories. (A)
  
• Intake of trans fat should be minimized. (E)
  
• Weight loss is recommended for all overweight (BMI 25.0–29.9 kg/m²) or obese (BMI 30.0 kg/m²) adults who have, or are at risk for developing, type 2 diabetes. (E)
  
• The primary approach for achieving weight loss is therapeutic lifestyle change, which includes a reduction in energy intake and an increase in physical activity. A moderate decrease in caloric balance (500–1,000 kcal/day) will result in a slow but progressive weight loss (1–2 lb/week). For most patients, weight loss diets should supply at least 1,000–1,200 kcal/day for women and 1,200–1,600 kcal/day for men. (E)
  
• Initial physical activity recommendations should be modest and based on the patient’s willingness and ability, gradually increasing the duration and frequency to 30–45 min of moderate aerobic activity, 3–5 days/week (goal at least 150 min/week). Greater activity levels of at least 1 h/day of moderate (walking) or 30 min/day of vigorous (jogging) activity may be needed to achieve successful long-term weight loss. (E)
  
• Drug therapy for obesity and surgery to induce weight loss may be appropriate in selected patients. (E)
  
• Nonnutritive sweeteners are safe when consumed within the acceptable daily intake levels established by the Food and Drug Administration (FDA). (A)
  
• If adults with diabetes choose to use alcohol, daily intake should be limited to a moderate amount (one drink per day or less for adult women and two drinks per day or less for adult men); one drink is defined as 12 oz beer, 5 oz wine, or 1.5 oz distilled spirits. (A)
  
• Routine supplementation with antioxidants, such as vitamins E and C and ß-carotene, is not advised because of lack of evidence of efficacy and concern related to long-term safety. (A)
  
• Benefit from chromium supplementation in people with diabetes or obesity has not been conclusively demonstrated and, therefore, cannot be recommended. (E)
  

MNT is an integral component of diabetes prevention, management, and self-management education. In addition to its role in preventing and controlling diabetes, the ADA recognizes the importance of nutrition as an essential component of an overall healthy lifestyle. These guidelines are based on principles of good nutrition for the overall population from the 2005 Dietary Guidelines and the RDAs from the Institute of Medicine of the National Academies of Sciences. A review of the evidence and detailed information can be found in the 2002 ADA technical review on this topic (35) and the 2004 ADA Statements regarding dietary carbohydrate (36) and weight management. (37).

Goal of MNT that applies to individuals with pre-diabetes:

• Decrease the risk of diabetes and CVD by promoting physical activity and healthy food choices that result in moderate weight loss that is maintained or, at a minimum, prevents weight gain.
  

Goal of MNT that applies to all individuals with diabetes:

• Prevent and treat the chronic complications of diabetes by attaining and maintaining optimal metabolic outcomes, including blood glucose and A1C level, LDL and HDL cholesterol and triglyceride levels, blood pressure, and body weight (Table 6).
  

Achieving nutrition-related goals requires a coordinated team effort that includes the active involvement of the person with pre-diabetes or diabetes. Because of the complexity of nutrition issues, it is recommended that a registered dietitian who is knowledgeable and skilled in implementing nutrition therapy into diabetes management and education be the team member who provides MNT. However, it is essential that all team members are knowledgeable about nutrition therapy and are supportive of the person with diabetes who needs to make lifestyle changes.

MNT involves a nutrition assessment to evaluate the patient’s food intake, metabolic status, lifestyle, readiness to make changes, goal setting, dietary instruction, and evaluation. To facilitate adherence, the plan should be individualized and take into account individual cultural, lifestyle, and financial considerations. Monitoring of glucose and A1C, lipids, blood pressure, and renal status is essential to evaluate nutrition-related outcomes. If goals are not met (Table 6), changes must be made in the overall diabetes care and management plan.

Weight management (37)
Overweight and obesity are strongly linked to the development of type 2 diabetes and can complicate its management. Obesity is also an independent risk factor for hypertension and dyslipidemia as well as CVD, which is the major cause of death in those with diabetes. Moderate weight loss improves glycemic control, reduces CVD risk, and can prevent the development of type 2 diabetes in those with pre-diabetes. Therefore, weight loss is an important therapeutic strategy in all overweight or obese individuals who have type 2 diabetes or are at risk for developing diabetes. The primary approach for achieving weight loss, in the vast majority of cases, is therapeutic lifestyle change, which includes a reduction in energy intake and an increase in physical activity. A moderate decrease in caloric balance (500–1,000 kcal/day) will result in a slow but progressive weight loss (1–2 lb/week). For most patients, weight loss diets should supply at least 1,000–1,200 kcal/day for women and 1,200–1,600 kcal/day for men.

In selected patients, drug therapy to achieve weight loss as an adjunct to lifestyle change may be appropriate (38). However, it is important to note that regain of weight commonly occurs on discontinuation of medication. In patients with severe/morbid obesity, surgical options, such as gastric bypass and gastroplasty, may be appropriate and allow significant improvement in glycemic control with reduction or discontinuation of medications (39). It is important to fully evaluate the patient for existing or risk for CVD and improve glycemic control preoperatively in order to decrease the risk of complications. It is important to counsel patients on the risks of surgery, including mortality, depression, hypoglycemia, nutritional deficiencies, osteoporosis, and weight regain over the long term. Very little data are currently available on the long-term consequences of surgery for weight loss in people with diabetes. The potential benefits should be weighed against short- and long-term risks (40).

Physical activity is an important component of a comprehensive weight-management program. Regular moderate-intensity physical activity enhances long-term weight maintenance. Regular activity also improves insulin sensitivity, glycemic control, and selected risk factors for CVD (i.e., hypertension and dyslipidemia), and increased aerobic fitness decreases the risk of coronary heart disease (CHD). Initial physical activity recommendations should be modest, based on the patient’s willingness and ability, gradually increasing the duration and frequency to 30–45 min of moderate aerobic activity, 3–5 days/week, when possible. Greater activity levels of at least 1 h/day of moderate (walking) or 30 min/day of vigorous (jogging) activity may be needed to achieve successful long-term weight loss.

Dietary carbohydrate (36)
Regulation of blood glucose to achieve near-normal levels is a primary goal in the management of diabetes, and thus, dietary techniques that limit hyperglycemia following a meal are important in limiting the complications of diabetes. Both the amount (grams) and type of carbohydrate in a food influence blood glucose level. The total amount of carbohydrate consumed is a strong predictor of glycemic response, and thus, monitoring total grams of carbohydrate, whether by use of exchanges or carbohydrate counting, remains a key strategy in achieving glycemic control. A recent analysis of the randomized controlled trials that have examined the efficacy of the glycemic index (a measure of the effect of type of carbohydrate) on overall blood glucose control indicates that the use of this technique may provide an additional benefit over that observed when total carbohydrate is considered alone.

Low-carbohydrate diets are not recommended in the management of diabetes. Although dietary carbohydrate is the major contributor to postprandial glucose concentration, it is an important source of energy, water-soluble vitamins and minerals, and fiber. Thus, in agreement with the National Academy of Sciences–Food and Nutrition Board (41), a recommended range of carbohydrate intake is 45–65% of total calories. In addition, because the brain and central nervous system have an absolute requirement for glucose as an energy source, restricting total carbohydrate to <130 g/day is not recommended.

Dietary protein
In the U.S., mean protein intake from foods (not including supplements) accounts for 15–20% of average energy intake, is fairly consistent across all ages from childhood to old age, and appears to be similar in individuals with diabetes. The dietary reference intake (DRI)-acceptable macronutrient distribution range for protein is 10–35% of energy intake and the RDA is 0.8 g high-quality protein · kg body wt^–1 · day^–1 (41).

Dietary intake of protein is similar to that of the general public in individuals with diabetes and usually does not exceed 20% of energy intake. Intake of protein in this range may be a risk factor for the development of diabetic nephropathy (42). Based on studies in patients with varying stages of nephropathy (42–44), it seems prudent to limit protein intake in those with diabetes to the RDA (0.8 g/kg), which would be 10% of total calories.

Dietary fat
Saturated and trans fatty acids are the principal dietary determinant of plasma LDL cholesterol, the major risk factor for CVD. In nondiabetic individuals, reducing saturated and trans fatty acids and cholesterol intake decreases plasma total and LDL cholesterol but may also reduce HDL cholesterol. Importantly, the ratio of LDL to HDL cholesterol is not adversely affected. Studies in individuals with diabetes demonstrating the effects of specific percentages of dietary saturated and trans fatty acids and specific amounts of dietary cholesterol on CVD risk are not available. However, those with diabetes are considered to be at similar risk to those with a past history of CVD. Therefore, because of a lack of specific information, the goal for dietary fat intake (amount and type) for individuals with diabetes is the same as for those without diabetes with a history of CVD. The most recent guidelines from the National Cholesterol Education Program recommend that total fat be 25–35% of total calories and saturated fat <7% (34). Guidelines from the American Heart Association also recommend that saturated fat be <7% in those with diabetes, given their increased risk of CVD (45,46). Intake of trans fat should be minimized.

Optimal macronutrient mix
For those individuals seeking guidance regarding macronutrient distribution, the DRIs may be helpful The DRI report recommends that to meet the body’s daily nutritional needs while minimizing risk for chronic diseases, adults (in general, not specifically those with diabetes) should consume 45–65% of total energy from carbohydrate, 20–35% from fat, and 10–35% from protein (41). Although numerous studies have attempted to identify the optimal combination of macronutrients for those with diabetes, it is unlikely that any one such combination of macronutrients exists. The best mix of carbohydrate, protein, and fat appears to vary depending on individual circumstances.

Fiber
Similar to the general population, people with diabetes are encouraged to choose a variety of fiber-containing foods, such as legumes, fiber-rich cereals (5 g fiber/serving), as well as fruits, vegetables, and whole-grain products because they provide vitamins, minerals, fiber, and other substances important for good health.

Reduced calorie sweetners
Reduced calorie sweeteners approved by the FDA include sugar alcohols (erythritol, hydrogenated starch hydrolysates, isomalt, lactitol, maltitol, mannitol, sorbitol, and xylitol) and tagatose. Studies using subjects with and without diabetes have shown that sugar alcohols produce a lower postprandial glucose response than sucrose or glucose and have lower available energy. Sugar alcohols contain, on average, 2 calories/gram (one-half the calories of other sweeteners such as sucrose). With foods containing sugar alcohols, subtraction of one-half of sugar alcohol grams from total carbohydrate grams is appropriate, particularly when using the carbohydrate counting method for meal planning. There is no evidence that the amounts of sugar alcohol likely to be consumed will result in significant reduction in energy intake or long-term improvement in glycemia. The use of sugar alcohols appears to be safe.

The FDA has approved five nonnutritive sweeteners for use in the U.S.: acesulfame potassium, aspartame, neotame, saccharin, and sucralose. All have undergone rigorous scrutiny and have been shown to be safe when consumed by the public, including people with diabetes and women who are pregnant.

Antioxidants
Since diabetes may be a state of increased oxidative stress, there has been interest in prescribing antioxidant vitamins to individuals with diabetes. While observational studies have shown a correlation between dietary or supplemental consumption of antioxidants and a variety of clinical outcomes such as prevention of disease states (35,47), large placebo-controlled clinical trials have failed to show a benefit and, in some instances, have suggested adverse effects (35,47).

Chromium
Several small studies have suggested a role for chromium supplementation in the management of glucose intolerance, body weight, GDM, and corticosteroid-induced diabetes (48–50). Also, placebo-controlled studies conducted in China found that chromium supplementation had beneficial effects on glycemia, although it is important to note that the study population in China may have had marginal baseline chromium status. A recent FDA statement indicated that there is insufficient evidence to support any of the proposed health claims for chromium supplementation. The FDA concluded that although a small study suggested that chromium picolinate may reduce the risk of insulin resistance, the existence of a relationship between chromium picolinate and either insulin resistance or type 2 diabetes was highly uncertain (see "chromium picolinate and insulin resistance" at www.cfsan.fda.gov/dms/qhccr.html). In addition, a meta-analysis of randomized controlled trials suggested no benefit of chromium picolinate supplementation in reducing body weight (51).

Alcohol
For individuals with diabetes, the same precautions apply regarding the use of alcohol that apply to the general population. If individuals choose to use alcohol, alcohol-containing beverages should be limited to a moderate amount (less than one drink per day for adult women and less than two drinks per day for adult men). One alcohol containing beverage is defined as 12 oz beer, 5 oz wine, or 1.5 oz distilled spirits. Each contains 15 g alcohol.

	E. DSME

TOP CONTENTS I. CLASSIFICATION AND DIAGNOSIS II. SCREENING FOR DIABETES III. DETECTION AND DIAGNOSIS... IV. PREVENTION/DELAY OF TYPE... V. DIABETES CARE E. DSME F. Physical activity G. Psychosocial assessment and... H. Referral for diabetes... I. Intercurrent illness J. Hypoglycemia K. Immunization VI. PREVENTION AND MANAGEMENT... E. Foot care VII. DIABETES CARE IN... VIII. DIABETES CARE IN... B. Diabetes care in... C. Diabetes care at... D. Diabetes management in... IX. HYPOGLYCEMIA AND... X. THIRD-PARTY REIMBURSEMENT FOR... References

 
Recommendations

• People with diabetes should receive DSME according to national standards when their diabetes is diagnosed and as needed thereafter. (B)
  
• DSME should be provided by health care providers who are qualified to provide that DSME based on their professional training and continuing education. (E)
  
• DSME should address psychosocial issues, since emotional well-being is strongly associated with positive diabetes outcomes. (C)
  
• DSME should be reimbursed by third-party payors. (E)
  

DSME is an essential element of diabetes care (52–58), and National Standards for DSME are based on evidence for its benefits. Education helps people with diabetes initiate effective self-care when they are first diagnosed. Ongoing DSME also helps people with diabetes maintain effective self-management as their diabetes presents new challenges and treatment advances become available. DSME helps patients optimize metabolic control, prevent and manage complications, and maximize quality of life, in a cost-effective manner.

Evidence for the benefits of DSME
Since the 1990s, there has been a shift from a didactic approach with DSME focusing on providing information to a skill-based approach that focuses on helping those with diabetes make informed self-management choices. Several studies have found that DSME is associated with improved diabetes knowledge (53), improved self-care behavior (53), improved clinical outcomes such as lower A1C (54,55,57,58), lower self-reported weight (53), and improved quality of life (56). Better outcomes were reported for DSME that were longer and included follow-up support (53), were tailored to individual needs and preferences (52), and addressed psychosocial issues (52,53,57).

The national standards for DSME
ADA-recognized DSME programs have staff that includes at least a registered nurse and a registered dietitian; these staff must be certified diabetes educators or have recent experience in diabetes education and management. The curriculum of ADA-recognized DSME programs must cover all areas of diabetes management, with the assessed needs of the individual determining which areas are addressed. All ADA-recognized DSME programs utilize a process of continuous quality improvement to evaluate the effectiveness of the DSME provided and to identify opportunities for improvement.

Reimbursement for DSME
DSME is reimbursed as part of the Medicare program as overseen by the Center for Medicare and Medicaid Services (CMS) (http://www.hcfa.gov/coverage).

	F. Physical activity

TOP CONTENTS I. CLASSIFICATION AND DIAGNOSIS II. SCREENING FOR DIABETES III. DETECTION AND DIAGNOSIS... IV. PREVENTION/DELAY OF TYPE... V. DIABETES CARE E. DSME F. Physical activity G. Psychosocial assessment and... H. Referral for diabetes... I. Intercurrent illness J. Hypoglycemia K. Immunization VI. PREVENTION AND MANAGEMENT... E. Foot care VII. DIABETES CARE IN... VIII. DIABETES CARE IN... B. Diabetes care in... C. Diabetes care at... D. Diabetes management in... IX. HYPOGLYCEMIA AND... X. THIRD-PARTY REIMBURSEMENT FOR... References

 
Recommendations

• To improve glycemic control, assist with weight maintenance, and reduce risk of CVD, at least 150 min/week of moderate-intensity aerobic physical activity (50–70% of maximum heart rate) is recommended and/or at least 90 min/week of vigorous aerobic exercise (>70% of maximum heart rate). The physical activity should be distributed over at least 3 days/week and with no more than 2 consecutive days without physical activity. (A)
  
• In the absence of contraindications, people with type 2 diabetes should be encouraged to perform resistance exercise three times a week, targeting all major muscle groups, progressing to three<