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The Effect of Glucose Variability on the Risk of Microvascular Complications in Type 1 Diabetes

Response to Kilpatrick et al.

From the Division of Endocrinology and Metabolism, Mayo Clinic, Rochester, Minnesota

Address correspondence to F.J. Service, MD, PhD, Division of Endocrinology and Metabolism, Mayo Clinic, 200 First St., N.W., Rochester, MN 55905. E-mail: service.john{at}mayo.edu

We have read with interest the article by Kilpatrick et al. (1), which reports the lack of effect of glucose variability on the risk for microvascular complications in type 1 diabetes using the Diabetes Control and Complications Trial database. We are pleased that the authors came to the same conclusions as we did in our examination (2) of this question using the same database. Since Diabetes Control and Complications Trial subjects were studied for differing durations and not all subjects provided complete seven-point glucose samples, how were these factors dealt with in the analysis? Furthermore, what were the reasons to limit the assessment of glucose variability to SD and omit measurements of M value and mean amplitude of glycemic excursion, two established indexes of glucose variability? The authors may wish to reexamine their literature research technique; it appears to be less than rigorous.

References

1. Kilpatrick ES, Rigby AS, Atkin SL: The effect of glucose variability on the risk of microvascular complications in type 1 diabetes. Diabetes Care 29:1486–1490, 2006[Abstract/Free Full Text]
   
2. Service FJ, O’Brien PC: The relation of glycaemia to the risk of development and progression of retinopathy in the Diabetic Control and Complications Trail. Diabetologia 44:1215–1220, 2001[Medline]
   

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This Article Extract Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Service, F.J. Articles by O'Brien, P. C. Search for Related Content PubMed PubMed Citation Articles by Service, F.J. Articles by O'Brien, P. C. Social Bookmarking                What's this?