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Vitamin D, Parathyroid Hormone Levels, and the Prevalence of Metabolic Syndrome in Community-Dwelling Older Adults

Response to Lippi et al.

¹ Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland
² Department of Family and Preventive Medicine, University of California, San Diego, La Jolla, California

Address correspondence to Jared P. Reis, PHD, Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 2024 E. Monument St., Suite 2-600, Baltimore, MD 21287. E-mail: jaredreis{at}hotmail.com

We thank Lippi et al. (1) for their comment to our recent article (2) examining the cross-sectional relation of 25-hydroxyvitamin D [25(OH)D] and parathyroid hormone (PTH) with metabolic syndrome and its components in a community-dwelling sample of older adults. Although Lippi et al. claim we found no association of 25(OH)D or PTH levels with components of metabolic syndrome, we would like to clarify that in men we did indeed observe dose-response associations of 25(OH)D and PTH with fasting hyperglycemia that were not explained by numerous potential confounders. However, we failed to confirm these findings in women.

In agreement with our results, Lippi et al. report no association of 25(OH)D or PTH levels with the prevalence of hyperglycemia, hypertriglyceridemia, or low HDL concentrations among older women. Taken together, these inconsistent findings highlight the need for well-performed prospective studies to determine what role, if any, 25(OH)D or PTH plays in the development of metabolic syndrome or its components. Optimally, these studies should include individuals residing in areas exposed to varying amounts of direct sunlight to ensure adequate variability in 25(OH)D levels.

References

1. Lippi G, Montagnana M, Targher G, Guidi GC: Vitamin D, parathyroid hormone levels, and the prevalence of metabolic syndrome in community-dwelling older adults. Diabetes Care 30:e135, 2007. DOI: 10.2337/dc07-1605[Free Full Text]
   
2. Reis JP, von Mühlen D, Kritz-Silverstein D, Wingard DL, Barrett-Connor E: Vitamin D, parathyroid hormone levels, and the prevalence of metabolic syndrome in community-dwelling older adults. Diabetes Care 30:1549–1555, 2007[Abstract/Free Full Text]
   

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This Article Extract Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Reis, J. P. Articles by von Mühlen, D. Search for Related Content PubMed Articles by Reis, J. P. Articles by von Mühlen, D. Social Bookmarking                What's this?