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IGF-Binding Protein-1 Levels Are Related to Insulin-Mediated Glucose Disposal and Are a Potential Serum Marker of Insulin Resistance

Response to van Haeften et al.

¹ Diabetes Center, Department of Medicine, University of California, San Francisco, California
² School of Life Science, Arizona State University, Tempe, Arizona

Address correspondence to Dr. Ira Goldfine, UCSF, 2200 Post, C415, San Francisco, CA 94143-1616. E-mail: ira.goldfine{at}ucsf.edu

We appreciate the interest of van Haeflen et al. (1) in our article (2) concerning IGF-binding protein (IGFBP)-1 as a maker of insulin resistance in healthy nondiabetic subjects. In contrast to our study, they did not find a strong a correlation between insulin action as determined by the hyperinsulinemic clamp and levels of IGFBP-1. There are several possible explanations for the difference in results between their study and ours. First, they provided no direct information about the patients other than that they were not diabetic. They cite a reference concerning their study of insulin resistance in heart failure patients on various medications (3), and it would appear that these patients were the ones studied. In contrast to sick patients, we studied healthy nondiabetic individuals with a broad range of insulin sensitivity. Thus, the difference between the studies could be the difference in patient populations and/or the medications their patients were taking. We drew samples for IGFBP-1 between 7 A.M. and 9 A.M. in fasting subjects. It is unknown whether their patients were fasting when the protein was measured and at what times the samples were drawn. Since there is a diurnal variation for IGF-binding protein 1, it is possible that they drew samples at different times during the day, which would alter the results. Considering all these unknown variables, we believe it is not possible to compare our study with theirs.

References

1. van Haeften TW, Zonderland ML, Sabelis LWE, van Doorn J: IGF-binding protein-1 levels are related to insulin-mediated glucose disposal and are a potential serum marker of insulin resistance (Letter). Diabetes Care 30:e53, 2007. DOI: 10.2337/dc07-0176[Free Full Text]
   
2. Maddux BA, Chan A, Mandarino LJ, Goldfine ID, DeFilippis EA: IGF-binding protein-1 levels are related to insulin-mediated glucose disposal and are a potential serum marker of insulin resistance. Diabetes Care 29:1535–1537, 2006[Abstract/Free Full Text]
   
3. Sabelis LWE, Senden PJ, Zonderland ML, van de Wiel A, Wielders JP, Huisveld IA, van Haeften TW, Mosterd WL: Determinants of insulin sensitivity in chronic heart failure. Eur J Heart Failure 5:759–765, 2003[Medline]
   

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This Article Extract Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Maddux, B. A. Articles by Goldfine, I. D. Search for Related Content PubMed Articles by Maddux, B. A. Articles by Goldfine, I. D. Social Bookmarking                What's this?