Diabetes Care
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Diabetes Care 30:e80 2007
DOI: 10.2337/dc07-0638
© 2007 by the American Diabetes Association
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Online Letters: Comments and Responses

Progression From Newly Acquired Impaired Fasting Glucose to Type 2 Diabetes

Response to Dinneen and Rizza

Gregory A. Nichols, PHD, Teresa A. Hillier, MD, MS and Jonathan B. Brown, PHD, MPP

From the Kaiser Permanente Center for Health Research, Portland, Oregon

Address correspondence to Gregory A. Nichols, PhD, Center for Health Research, 3800 N. Interstate Ave., Portland, OR 97227-1098. E-mail: greg.nichols{at}kpchr.org

In response to our report on progression from impaired fasting glucose to diabetes (1), Dinneen and Rizza (2) note that they had previously demonstrated a clear gradation of risk of progression to diabetes among nondiabetic individuals with baseline fasting plasma glucose (FPG) <100 mg/dl (3). They express interest in knowing whether this observation can be replicated in our data. Unfortunately, the study in question did not include individuals with normal fasting glucose. However, in a related study previously reported in Diabetes Care (4), we identified over 28,000 health plan members with baseline FPG under 100 mg/dl on whom such analyses are possible. We are currently preparing a manuscript that will fully address this important issue and are therefore precluded from reporting that data here. Nevertheless, we concur with Dinneen and Rizza (2) that the relative risk of diabetes likely increases with rising fasting glucose even at apparently normal FPG levels.

References

  1. Nichols GA, Hillier TA, Brown JB: Progression from newly acquired impaired fasting glucose to type 2 diabetes. Diabetes Care 30:228–233, 2007[Abstract/Free Full Text]
  2. Dinneen SF, Rizza RA: Progression from impaired fasting glucose to type 2 diabetes (Letter). Diabetes Care 30:e79, 2007. DOI: 10.2337/dc07-0530[Free Full Text]
  3. Dinneen SF, Maldonado D, Leibson CL, Klee GG, Li H, Melton LJ, Rizza RA: Effects of changing diagnostic criteria on the risk of developing diabetes. Diabetes Care 21:1408–1413, 1998[Abstract]
  4. Nichols GA, Brown JB: Higher medical costs accompany impaired fasting glucose. Diabetes Care 28:2223–2229, 2005[Abstract/Free Full Text]

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This Article
Right arrow Extract Freely available
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