HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: dc06-2107v1 30/5/1233    most recent Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Williams, C. J. Articles by Mantzoros, C. S. Search for Related Content PubMed PubMed Citation Articles by Williams, C. J. Articles by Mantzoros, C. S. Social Bookmarking                What's this?

Sleep Duration and Snoring in Relation to Biomarkers of Cardiovascular Disease Risk Among Women With Type 2 Diabetes

¹ Department of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts
² Department of Nutrition and Epidemiology, Harvard School of Public Health, Boston, Massachusetts
³ Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts
⁴ Pulmonary and Critical Care Medicine, University Hospitals of Cleveland, Case Western Reserve University, Cleveland, Ohio

Address correspondence and reprint requests to Dr. Christos Mantzoros, Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, 330 Brookline Ave., ST816, Boston, MA 02115. E-mail: cmantzor{at}bidmc.harvard.edu

OBJECTIVE—Sleep habits have been associated with risk of cardiovascular disease (CVD) and metabolic disturbances, but the mechanisms underlying these associations have yet to be fully elucidated. We aim to determine whether sleep duration and/or snoring are associated with biomarkers of CVD in women with type 2 diabetes.

RESEARCH DESIGN AND METHODS—We studied 935 women aged 43–69 years enrolled in the Nurses’ Health Study cohort with type 2 diabetes who had no history of documented coronary heart disease or stroke in 1990. Information on sleep duration and snoring frequency was collected in 1986 from mailed questionnaires, and biomarkers of CVD were measured from blood samples taken in 1989–1990.

RESULTS—Longer sleep duration was associated with increased levels of C-reactive protein after adjusting for age, BMI, lifestyle factors, family history of diabetes, glycemic control, and medication use (P = 0.05). HDL was decreased with short and long sleep duration among normotensive (P = 0.02) but not hypertensive women. More frequent snoring was directly associated with triglycerides (P = 0.02) and inversely associated with HDL cholesterol (0.03) and adiponectin (P = 0.03) in multivariate-adjusted analyses.

CONCLUSIONS—The associations of sleep duration and snoring with lipid profile, hormone measures, and/or inflammatory markers may partially explain the previously reported relationship between sleep habits and cardiovascular and metabolic disorders.

Abbreviations: CRP, C-reactive peptide • CVD, cardiovascular disease • NHS, Nurses’ Health Study • OSA, obstructive sleep apnea • sICAM-1, soluble intercellular adhesion molecule 1 • TNF, tumor necrosis factor • WHR, waist-to-hip ratio

CiteULike    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				J. F. van den Berg, H. M. E. Miedema, J. H. M. Tulen, A. K. Neven, A. Hofman, J. C. M. Witteman, and H. Tiemeier Long Sleep Duration is Associated With Serum Cholesterol in the Elderly: The Rotterdam Study Psychosom Med, November 1, 2008; 70(9): 1005 - 1011. [Abstract] [Full Text] [PDF]

				A. Shankar, W.-P. Koh, J.-M. Yuan, H.-P. Lee, and M. C. Yu Sleep Duration and Coronary Heart Disease Mortality Among Chinese Adults in Singapore: A Population-based Cohort Study Am. J. Epidemiol., October 23, 2008; (2008) kwn281v1. [Abstract] [Full Text] [PDF]