HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: dc06-2187v1 30/6/1418    most recent Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Mishra, G. D. Articles by Dobson, A. J. Search for Related Content PubMed PubMed Citation Articles by Mishra, G. D. Articles by Dobson, A. J. Social Bookmarking                What's this?

Short-Term Weight Change and the Incidence of Diabetes in Midlife

Results from the Australian Longitudinal Study on Women's Health

¹ School of Population Health, University of Queensland, Queensland, Australia
² School of Human Movement Studies, University of Queensland, Queensland, Australia

Address correspondence and reprint requests to Gita Mishra, PhD, School of Population Health, University of Queensland, Herston 4006, Australia. E-mail: g.mishra{at}uq.edu.au

OBJECTIVE—Although there is consensus that excess adiposity is strongly associated with type 2 diabetes, its relationship with weight change is less clear. This study investigates the relative impact of BMI at baseline and short-term (2- or 3-year) weight changes on the incidence of diabetes.

RESEARCH DESIGN AND METHODS—Prospective data were collected from a population-based cohort of middle-aged women participating in the Australian Longitudinal Study on Women's Health (n = 7,239 for this report). To date, participants have completed four mailed surveys (S1, 1996; S2, 1998; S3, 2001; and S4, 2004). Generalized estimating equations were used to model binary repeated-measures data to assess the impact of BMI at S1 and weight change (S1 to S2; S2 to S3) on 3-year incidence of diabetes at S3 and S4, respectively, adjusting for sociodemographic and lifestyle factors.

RESULTS—BMI at S1 was strongly associated with the development of diabetes by S3 or S4. Compared with women who had a BMI <25 kg/m², those with BMI 25 kg/m² had higher incidence of diabetes (P < 0.0001), with odd ratios reaching 12.1 (95% CI 7.6–19.3) for women in the very obese group (BMI 35 kg/m²). There was no association between shorter-term weight gain or weight loss on first-reported diagnosis of diabetes (P = 0.08).

CONCLUSIONS—Because women's risk of developing type 2 diabetes in midlife is more closely related to their initial BMI (when aged 45–50 years) than to subsequent short-term weight change, public health initiatives should target the prevention of weight gain before and during early adulthood.

Abbreviations: ALSWH, Australian Longitudinal Study on Women's Health

CiteULike    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				Midlife BMI Predicts Diabetes Risk DOC News, August 1, 2007; 4(8): 10 - 10. [Full Text]