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Published online January 30, 2008
Diabetes Care 31:974-976, 2008
DOI: 10.2337/dc07-2101
© 2008 by the American Diabetes Association
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Pathophysiology/Complications
Original Research

C-Reactive Protein in Relation to the Development of Microalbuminuria in Type 1 Diabetes

The Oxford Regional Prospective Study

M. Loredana Marcovecchio, MD1,2, Cosimo Giannini, MD2, Barry Widmer, BSC1, R. Neil Dalton, PHD3, Stefano Martinotti, MD4, Francesco Chiarelli, MD2 and David B. Dunger, MD1

1 University Department of Paediatrics, Addenbrooke's Hospital, Cambridge, U.K.
2 University Department of Paediatrics, Chieti, Italy
3 WellChild Laboratory, Evelina Children's Hospital, London, U.K.
4 Department of Pathology, Chieti, Italy

Corresponding author: David B. Dunger, University Department of Paediatrics, Addenbrooke's Hospital, Hills Rd., Cambridge CB22QQ, U.K. E-mail: dbd25{at}cam.ac.uk

OBJECTIVES—To perform a longitudinal evaluation of high-sensitivity C-reactive protein (hs-CRP) in young people with type 1 diabetes in relation to the development of microalbuminuria (MA).

RESEARCH DESIGN AND METHODS—hs-CRP was measured in 329 blood samples collected from 49 subjects with type 1 diabetes with MA and 49 normoalbuminuric subjects matched for age, sex, and duration of diabetes.

RESULTS—In subjects developing MA, a progressive rise in hs-CRP was detected with levels significantly higher in the years after the onset of MA when compared with levels before MA onset (P = 0.003; age-adjusted P = 0.06). After the onset of MA, hs-CRP levels were significantly higher in subjects with MA when compared with normoalbuminuric subjects (median 1.9 mg/l [range 0.2–9.8] vs. 1.1 mg/l [0.2–6.4]; P = 0.02; adjusted P = 0.036).

CONCLUSIONS—In this population of young subjects with type 1 diabetes, there was a significant increase in hs-CRP levels after the onset of MA, likely reflecting a general state of inflammation.

Abbreviations: CRP, C-reactive protein • hs-CRP, high-sensitivity C-reactive protein • MA, microalbuminuria • MA+, with microalbuminuria • MA–, normoalbuminuric • SDS, SD score


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