HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) All Versions of this Article: dc06-1903v1 30/10/2458    most recent Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Deeg, M. A. Search for Related Content PubMed PubMed Citation Articles by Deeg, M. A. Social Bookmarking                What's this?

Pioglitazone and Rosiglitazone Have Different Effects on Serum Lipoprotein Particle Concentrations and Sizes in Patients with Type 2 Diabetes and Dyslipidemia

¹Endocrinology and Metabolism, Veterans Affairs Hospital and Indiana University, Indianapolis, Indiana;
²Endocrinology and General Medicine, University of North Carolina, Chapel Hill, North Carolina;
³Endocrinology, Metabolism and Diabetes, University of Miami, Miami, Florida;
⁴International Diabetes Center, Park Nicollet Institute, Minneapolis, Minnesota;
⁵Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana;
⁶Takeda Pharmaceuticals North America, Lincolnshire, Illinois;
⁷Takeda Global Research and Development, Lincolnshire, Illinois

tan_meng{at}lilly.com

ABSTRACT

Objective:Associated with insulin resistance in type 2 diabetes are increased serum triglycerides, decreased HDL-C, and a predominance of large VLDL, small LDL, and small HDL particles. The comparative effects of thiazolidinedione insulin sensitizers on serum lipoprotein particle concentrations and sizes in type 2 diabetes are not known. We studied the effects of pioglitazone (PIO) and rosiglitazone (ROSI) treatments on serum lipoprotein particle concentrations and sizes in type 2 diabetes patients with dyslipidemia.

Research Design and Methods:This is a prospective, randomized, double-blind, multi-center, parallel-group study. After a 4-week placebo washout period, patients randomized to PIO (n=369) were treated with 30 mg qd for 12 weeks followed by 45 mg qd for another 12 weeks, while patients randomized to ROSI (n=366) were treated with 4 mg qd followed by 4 mg bid for the same intervals. Lipoprotein subclass particle concentrations and sizes were determined by proton nuclear magnetic resonance spectroscopy at baseline and endpoint (PIO [n=333] and ROSI [n=325] patients).

Results:PIO-treatment increased total VLDL particle concentration less than ROSI-treatment and decreased VLDL particle size more than ROSI. PIO-treatment reduced total LDL particle concentration whereas ROSI-treatment increased it. Both treatments increased LDL particle size, with PIO-treatment having a greater effect. Whereas PIO-treatment increased total HDL particle concentration and size, ROSI-treatment decreased them; both increased HDL cholesterol levels.

Conclusion:PIO and ROSI treatments have different effects on serum lipoprotein subclass particle concentrations and sizes in patients type 2 diabetes and dyslipidemia.

Registered in clinicaltrials.gov as NCT00331487

CiteULike    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				T. D. Wiggin, M. Kretzler, S. Pennathur, K. A. Sullivan, F. C. Brosius, and E. L. Feldman Rosiglitazone Treatment Reduces Diabetic Neuropathy in Streptozotocin-Treated DBA/2J Mice Endocrinology, October 1, 2008; 149(10): 4928 - 4937. [Abstract] [Full Text] [PDF]

				I. Pagel-Langenickel, J. Bao, J. J. Joseph, D. R. Schwartz, B. S. Mantell, X. Xu, N. Raghavachari, and M. N. Sack PGC-1{alpha} Integrates Insulin Signaling, Mitochondrial Regulation, and Bioenergetic Function in Skeletal Muscle J. Biol. Chem., August 15, 2008; 283(33): 22464 - 22472. [Abstract] [Full Text] [PDF]

				A. M.G. Cali, T. L. Zern, S. E. Taksali, A. M. de Oliveira, S. Dufour, J. D. Otvos, and S. Caprio Intrahepatic Fat Accumulation and Alterations in Lipoprotein Composition in Obese Adolescents: A perfect proatherogenic state Diabetes Care, December 1, 2007; 30(12): 3093 - 3098. [Abstract] [Full Text] [PDF]

				S. Singh, Y. K. Loke, and C. D. Furberg Long-term Risk of Cardiovascular Events With Rosiglitazone: A Meta-analysis JAMA, September 12, 2007; 298(10): 1189 - 1195. [Abstract] [Full Text] [PDF]