HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) All Versions of this Article: dc06-1994v1 30/4/980    most recent Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by PITTAS, A. G. Articles by DAWSON-HUGHES, B. Search for Related Content PubMed PubMed Citation Articles by PITTAS, A. G. Articles by DAWSON-HUGHES, B. Social Bookmarking                What's this?

The Effects of Calcium and Vitamin D Supplementation on Blood Glucose and Markers of Inflammation in Non-diabetic Adults

¹Endocrinology, Diabetes and Metabolism
²Institute for Clinical Research and Health Policy Studies, Tufts-New England Medical Center, Boston, MA 02111
³Bone Metabolism Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA

apittas{at}tufts-nemc.org

ABSTRACT

Objective. To compare the effects of combined calcium and vitamin D supplementation vs. placebo on blood glucose and markers of inflammation in non-diabetic adults 65 years of age or older.

Research Design and Methods. 314 Caucasian adults without diabetes received either 500 mg of calcium citrate and 700 IU of vitamin D₃ or placebos daily for 3 years in a double-blind randomized controlled trial designed for bone-related outcomes. In a post-hoc analysis, fasting plasma glucose (FPG), insulin sensitivity estimated by homeostasis model assessment-insulin resistance (HOMA-IR), plasma C-reactive protein and interleukin-6 were measured at baseline and 3 years.

Results. The effects of combined calcium-vitamin D supplementation on 3-year change in FPG depended on baseline FPG (p=0.02 for interaction). Therefore, we conducted analyses separately in participants with normal fasting glucose (NFG: FPG <5.6 mmol/L, n=222) and impaired fasting glucose (IFG: FPG 5.6-6.9 mmol/L, n=92) at baseline. Among participants with IFG at baseline those who took combined calcium-vitamin D supplements had a lower rise in FPG at 3 years compared to those on placebo (0.02 mmol/L [0.4 mg/dl] vs. 0.34 mmol/L [6.1 mg/dl] respectively; p=0.042), and a lower increase in HOMA-IR (0.05 vs. 0.91; p=0.031). In the NFG subgroup, there was no difference in the change in FPG or HOMA-IR between the two treatment arms. There were no differences in C-reactive protein or interleukin-6 between the two treatment arms in either subgroup.

Conclusions. In healthy older adults with impaired fasting glucose, supplementation with calcium and vitamin D may attenuate increases in glycemia and insulin resistance that occur over time. However, our findings should be considered hypothesis generating and need to be confirmed in randomized trials specifically designed for the outcomes of interest. Clinicaltrials.gov identification #NCT00357643.

CiteULike    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				E. Giovannucci, Y. Liu, B. W. Hollis, and E. B. Rimm 25-Hydroxyvitamin D and Risk of Myocardial Infarction in Men: A Prospective Study Arch Intern Med, June 9, 2008; 168(11): 1174 - 1180. [Abstract] [Full Text] [PDF]

				G. Schwalfenberg Vitamin D and diabetes: Improvement of glycemic control with vitamin D3 repletion Can Fam Physician, June 1, 2008; 54(6): 864 - 866. [Full Text] [PDF]

				A. Y.-M. Wang, C. W.-K. Lam, J. E Sanderson, M. Wang, I. H.-S. Chan, S.-F. Lui, M. M.-M. Sea, and J. Woo Serum 25-hydroxyvitamin D status and cardiovascular outcomes in chronic peritoneal dialysis patients: a 3-y prospective cohort study Am. J. Clinical Nutrition, June 1, 2008; 87(6): 1631 - 1638. [Abstract] [Full Text] [PDF]

				M. L. Melamed, P. Muntner, E. D. Michos, J. Uribarri, C. Weber, J. Sharma, and P. Raggi Serum 25-Hydroxyvitamin D Levels and the Prevalence of Peripheral Arterial Disease: Results from NHANES 2001 to 2004 Arterioscler. Thromb. Vasc. Biol., June 1, 2008; 28(6): 1179 - 1185. [Abstract] [Full Text] [PDF]

				I. H. de Boer, L. F. Tinker, S. Connelly, J. D. Curb, B. V. Howard, B. Kestenbaum, J. C. Larson, J. E. Manson, K. L. Margolis, D. S. Siscovick, et al. Calcium Plus Vitamin D Supplementation and the Risk of Incident Diabetes in the Women's Health Initiative Diabetes Care, April 1, 2008; 31(4): 701 - 707. [Abstract] [Full Text] [PDF]

				M. C. Honeyman, S. Elkassaby, and L. C. Harrison Seasonal Changes in Preprandial Glucose, A1C, and Blood Pressure in Diabetic Patients: Response to Liang Diabetes Care, November 1, 2007; 30(11): e118 - e118. [Full Text] [PDF]

				S. Tournis and A. Mitrakou The Effects of Calcium and Vitamin D Supplementation on Blood Glucose and Markers of Inflammation in Nondiabetic Adults: Response to Pittas et al. Diabetes Care, July 1, 2007; 30(7): e81 - e81. [Full Text] [PDF]

				A. G. Pittas and B. Dawson-Hughes The Effects of Calcium and Vitamin D Supplementation on Blood Glucose and Markers of Inflammation in Nondiabetic Adults: Response to Tournis and Mitrakou Diabetes Care, July 1, 2007; 30(7): e82 - e82. [Full Text] [PDF]

				A. G. Pittas, J. Lau, F. B. Hu, and B. Dawson-Hughes The Role of Vitamin D and Calcium in Type 2 Diabetes. A Systematic Review and Meta-Analysis J. Clin. Endocrinol. Metab., June 1, 2007; 92(6): 2017 - 2029. [Abstract] [Full Text] [PDF]