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Chromium treatment has no effect in Patients with Type 2 Diabetes Mellitus in a Western Population: A Randomized, Double-Blind, Placebo-Controlled Trial

¹Diabetes Centre, Isala Clinics, Zwolle, The Netherlands
²Langerhans Medical Research Group, The Netherlands
³Department of Internal Medicine, University Medical Center Groningen, Groningen, The Netherlands
⁴Department of General Practice, University of Groningen, Groningen, The Netherlands

Kleefstra{at}Langerhans.com

ABSTRACT

OBJECTIVE: Chromium treatment has been reported to improve glycemic control in patients with type 2 diabetes. However, concern exists about possible toxic effects of chromium picolinate. The aim of this study was to determine the effect of chromium treatment in the form of chromium yeast on glycemic control in a western population of patients with type 2 diabetes who were being treated with oral hypoglycemic agents.

RESEARCH DESIGN AND METHODS: In this 6-month, double-blind study, patients with moderate glycemic control, being treated with oral hypoglycemic agents, were randomly assigned to receive either a placebo or treatment with 400 µg of chromium daily in the form of chromium yeast. The primary efficacy parameter was a change in HbA1c. Secondary endpoints were changes in lipid profile, BMI, blood pressure, body fat, and insulin resistance.

RESULTS: No differences were found for the change in HbA1c between the intervention and placebo groups. Nor were any differences found between the groups for the secondary endpoints.

CONCLUSIONS: There is no evidence that chromium in the form of chromium yeast is effective in improving glycemic control in western patients with type 2 diabetes who are taking oral hypoglycemic agents.

TRIAL REGISTRY: ClinicalTrials.gov; Registration Number: NCT00145093

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				N. Kleefstra, S. T. Houweling, and H. J.G. Bilo Effect of Chromium Supplementation on Glucose Metabolism and Lipids: A Systematic Review of Randomized Controlled Trials: Response to Balk et al. Diabetes Care, September 1, 2007; 30(9): e102 - e102. [Full Text] [PDF]