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Ferrritin and transferrin are associated with metabolic syndrome abnormalities and their change over time in a general population. The D.E.S.I.R. Study

¹INSERM Unité 780-IFR69, Epidemiological and Biostatistical Research, Villejuif, France
²Univ Paris Sud, Villejuif, France
³Ecoles des Hautes Etudes en Sciences Sociales, Paris, France
⁴IRSA Institut inter-Régionale pour la Santé, La Riche, France
⁵INSERM Unité 695, Genetic Determinants for Type 2 Diabetes and its Vascular Complications, Univ Paris 7, Xavier Bichat Medical School, Paris, France
⁶Department of Endocrinology, Diabetology, Nutrition and Metabolic Diseases, Xavier Bichat Hospital, Paris, France
⁷INSERM UMR 773, Denis Diderot Medical School, Université Paris 7, Paris, France
⁸Sevice de Biochimie hormonale et Génétique, AP-HP, Xavier Bichat Hospital, Paris, France

balkau{at}vjf.inserm.fr

ABSTRACT

OBJECTIVE: To study cross-sectional and longitudinal relations between iron stocks (ferritin) and the iron transport protein (transferrin) with the metabolic syndrome and its abnormalities.

METHODS: 469 men, 278 pre- and 197 post-menopausal women from the French D.E.S.I.R. cohort, aged 30-65 years, were followed over six years.

RESULTS: Higher concentrations of both ferritin and transferrin were associated with the IDF, NCEP-ATP III original and revised metabolic syndromes at baseline: for the IDF metabolic syndrome the standardized, age-adjusted odds ratios (95% CI) for log(ferritin) were: 1.49 (1.14-1.94) for men, 2.10 (1.27-3.48) for pre-menopausal women, 1.80 (1.21-2.68) for post-menopausal women; for transferrin they were respectively: 1.94 (1.53-2.47), 2.22 (1.32-3.75), 2.14 (1.47-3.10). After 6-years of follow-up, the change in the presence of the metabolic syndrome was associated with higher baseline log(ferritin) in all three groups: 1.46 (1.13-1.89), 1.28 (0.85-1.94), 1.62 (1.10-2.38), and transferrin: 1.41 (1.10-1.81), 1.63 (1.05-2.52), 1.51 (1.02-2.22). Among syndrome components, hypertriglyceridemia at 6 years was the component most strongly associated with baseline ferritin and transferrin. The odds of an incident IDF-defined metabolic syndrome after 6 years, was more than four-fold higher when ferritin and transferrin were both above the group-specific top tertile, in comparison with participants with both parameters below these thresholds.

CONCLUSIONS: This is the first prospective study associating ferritin and transferrin with the metabolic syndrome and its components. When both markers of the iron metabolism are elevated, the incidence of the metabolic syndrome is increased in men and both pre- and post-menopausal women.

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