HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Erratum Erratum (v31,p1922) All Versions of this Article: dc06-2344v1 30/5/1039    most recent Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Maki, K. C. Articles by Reeves, M. S. Search for Related Content PubMed PubMed Citation Articles by Maki, K. C. Articles by Reeves, M. S. Social Bookmarking                What's this?

High-viscosity Hydroxypropylmethylcellulose Blunts Postprandial Glucose and Insulin Responses

¹Provident Clinical Research, Bloomington, Indiana
²The Dow Chemical Company, Midland, Michigan

KMaki{at}ProvidentCRC.com

ABSTRACT

Objective. High-viscosity hydroxypropylmethylcellulose (HV-HPMC) is a modified cellulose fiber that produces a viscous gel in the gastrointestinal tract. Clinical trials demonstrate that consumption of HV-HPMC significantly lowers cholesterol, but limited information has been available on the influence of HV-HPMC on postprandial insulin and glucose responses. The objective of this investigation was to assess the influence of HV-HPMC on postprandial glucose and insulin responses in overweight and obese men and women.

Research Design and Methods. Participants were 31, overweight or obese men and women without diabetes who underwent 3 breakfast meal tests in random order, separated by 72 hours. Test meals contained 75 g carbohydrate plus 4 g or 8 g HV-HPMC, or control (8 g cellulose), delivered in a double-blind fashion.

Results. Peak glucose was significantly lower (p < 0.001) after both HV-HPMC-containing meals [7.4 mmol/L (4 g) and 7.4 mmol/L (8 g)] compared to the control meal (8.6 mmol/L). Peak insulin concentrations and the incremental areas for glucose and insulin from 0-120 min were also significantly reduced after both HV-HPMC doses vs. control (all p < 0.01).

Conclusions. These findings indicate that HV-HPMC consumption reduces postprandial glucose and insulin excursions, which may favorably alter risks for diabetes and cardiovascular disease.

REGISTRY NUMBER:: Exempt

CiteULike    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				K. C. Maki, M. L. Carson, M. P. Miller, M. Turowski, M. Bell, D. M. Wilder, T. M. Rains, and M. S. Reeves Hydroxypropylmethylcellulose and Methylcellulose Consumption Reduce Postprandial Insulinemia in Overweight and Obese Men and Women J. Nutr., February 1, 2008; 138(2): 292 - 296. [Abstract] [Full Text] [PDF]