HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) All Versions of this Article: dc06-2417v1 30/9/2251    most recent Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Kornum, J. B. Articles by Sørensen, H. T. Search for Related Content PubMed PubMed Citation Articles by Kornum, J. B. Articles by Sørensen, H. T. Social Bookmarking                What's this?

Type 2 Diabetes and Pneumonia Outcomes: A population-based cohort study

¹Clinical Epidemiology,
²Endocrinology, and
³Clinical Microbiology, Aarhus University Hospital, Aalborg, Denmark.

j.kornum{at}rn.dk

ABSTRACT

Objective: To examine whether type 2 diabetes increases risk of death and complications following pneumonia and to assess the prognostic value of admission hyperglycemia.

Research Design and Methods: Population-based cohort study of adults with a first-time hospitalization for pneumonia between 1997 and 2004 (n=29,900), in Northern Denmark Information on diabetes, comorbidity, laboratory findings, pulmonary complications, and bacteremia was obtained from medical databases. We used regression to compute adjusted relative risks (RRs) of pulmonary complications and bacteremia and mortality rate ratios (MRRs) within 90 days following hospitalization among patients with and without type 2 diabetes. The prognostic impact of admission hyperglycemia was studied in a subcohort (n=13,574).

Results: In total 2,931 (9.8%) pneumonia patients had type 2 diabetes. Mortality among diabetic patients was greater than that of other patients: 19.9% vs. 15.1% after 30 days and 27.0% vs. 21.6% after 90 days, corresponding to adjusted 30- and 90-day MRRs of 1.16 (95% CI 1.07-1.27) and 1.10 (95% CI 1.02-1.18). Presence of type 2 diabetes did not predict pulmonary complications or bacteremia. Adjustment for hyperglycemia attenuated the association between type 2 diabetes and mortality. High glucose level on admission was a predictor of death among patients with diabetes, and more so in those without diagnosed diabetes: adjusted 30-day MRR for glucose level 14 mmol/L, 1.46 (95% CI 1.01-2.12) and 1.91 (95% CI 1.40-2.61).

Conclusions: Type 2 diabetes and admission hyperglycemia predict increased pneumonia-related mortality.

CiteULike    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				D. J. Wexler, D. M. Nathan, R. W. Grant, S. Regan, A. L. Van Leuvan, and E. Cagliero Prevalence of Elevated Hemoglobin A1c among Patients Admitted to the Hospital without a Diagnosis of Diabetes J. Clin. Endocrinol. Metab., November 1, 2008; 93(11): 4238 - 4244. [Abstract] [Full Text] [PDF]

				J. B. Kornum, R. W. Thomsen, A. Riis, H.-H. Lervang, H. C. Schonheyder, and H. T. Sorensen Diabetes, Glycemic Control, and Risk of Hospitalization With Pneumonia: A population-based case-control study Diabetes Care, August 1, 2008; 31(8): 1541 - 1545. [Abstract] [Full Text] [PDF]