HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) All Versions of this Article: dc06-2429v1 30/6/1520    most recent Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Perseghin, G. Articles by Luzi, L. Search for Related Content PubMed PubMed Citation Articles by Perseghin, G. Articles by Luzi, L. Social Bookmarking                What's this?

Abnormal left ventricular energy metabolism in obese men with preserved systolic and diastolic functions is associated with insulin resistance

¹Internal Medicine -- Section of Nutrition/Metabolism, Istituto Scientifico San Raffaele, Milano, Italy
²Division of Nuclear Medicine, Istituto Scientifico San Raffaele, Milano, Italy
³Division of Diagnostic Radiology, Istituto Scientifico San Raffaele, Milano, Italy
⁴Unit of Clinical Spectroscopy, Istituto Scientifico San Raffaele, Milano, Italy
⁵Università Vita e Salute San Raffaele, Milan Italy
⁶Faculty of Exercise Sciences, Center "Physical exercise for health and wellness", Università degli Studi di Milano

perseghin.gianluca{at}hsr.it

ABSTRACT

Objective.: Perturbations in cardiac energy metabolism might represent early alterations in diabetes preceding functional and pathological changes. We evaluated left ventricular (LV) structure/geometry and function in relation to energy metabolism and cardiovascular risk factors in overweight/obese men using magnetic resonance (MR) techniques.

Research Design and Methods.: We studied 81 healthy men (age range: 22-55 years, BMI range: 19-35 kg/m²) by means of cardiac MR imaging (MRI) and ³¹P-MR spectroscopy (MRS) in the resting and fasted conditions and stratified them in quartiles of BMI (cut offs: 23.2, 25.5 and 29.0 kg/m²).

Results.: LV mass increased across quartiles of BMI meanwhile the volumes did not differ. Parameters of LV systolic and diastolic function were not different among quartiles. The phosphocreatine (PCr)/ATP ratio was reduced across increasing quartiles of BMI (2.25±0.52, 1.89±0.26, 1.99±0.38 and 1.79±0.29; P<0.006) in association with insulin sensitivity (computer HOMA2 model); this relation was independent of age, BMI, blood pressure, wall mass, HDL-cholesterol, triglycerides, smoking habits and metabolic syndrome.

Conclusion.: Abnormal LV energy metabolism was detectable in obese men in presence of normal function supporting the hypothesis that metabolic remodeling in insulin resistant states precedes functional and structural/geometrical remodeling of the heart regardless of the onset of overt hyperglycemia.

CiteULike    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				R. Harmancey, C. R. Wilson, and H. Taegtmeyer Adaptation and Maladaptation of the Heart in Obesity Hypertension, August 1, 2008; 52(2): 181 - 187. [Full Text] [PDF]

				R. W. van der Meer, S. Hammer, H. J. Lamb, M. Frolich, M. Diamant, L. J. Rijzewijk, A. de Roos, J. A. Romijn, and J. W. A. Smit Effects of Short-Term High-Fat, High-Energy Diet on Hepatic and Myocardial Triglyceride Content in Healthy Men J. Clin. Endocrinol. Metab., July 1, 2008; 93(7): 2702 - 2708. [Abstract] [Full Text] [PDF]