HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Online-Only Appendix All Versions of this Article: dc06-2487v1 30/10/2679    most recent Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Ribisl, P. M. Search for Related Content PubMed PubMed Citation Articles by Ribisl, P. M. Social Bookmarking                What's this?

Exercise Capacity and Cardiovascular/Metabolic Characteristics of Overweight and Obese Individuals with Type 2 Diabetes. The Look AHEAD Study

¹Wake Forest University, Winston-Salem, NC27109 (ribisl@wfu.edu)
²Wake Forest University School of Medicine, Winston-Salem, NC 27157 (wlang@wfubmc.edu; sjaramil@wfubmc.edu;jbahnson@wfubmc.edu)
³The University of Pittsburgh, Pittsburgh, PA 15203 (jjakicic@pitt.edu)
⁴Johns Hopkins University, Baltimore, MD 21224 (kstewart@mail.jhmi.edu)
⁵ Brown Medical School/The Miriam Hospital, Brown University, Providence, RI 02906 (rbright@lifespan.org)
⁶ Diabetes Epidemiology and Clinical Research Section, NIDDK, Phoenix, AZ 85014; (jfcurtis@mail.nih.gov)
⁷University of Minnesota, Minneapolis, MN 55415 (crow@epi.umn.edu)
⁸The University of Tennessee, Memphis, TN 38163 (jsoberman@utmem.edu)

ribisl{at}wfu.edu

ABSTRACT

OBJECTIVE --: We examined associations of cardiovascular, metabolic, and body composition measures with exercise capacity using baseline data from 5145 overweight and/or obese (BMI UU 25.0) men and women with type 2 diabetes (T2DM) who were randomized participants for the Look AHEAD clinical trial.

RESEARCH DESIGN AND METHODS --: Peak exercise capacity expressed as metabolic equivalents (METs) and estimated from treadmill speed and grade was measured during a graded exercise test (GXT) that was designed to elicit a maximal effort. Other measures included: waist circumference, BMI, T2DM duration, types of medication used, HbA1c, history of cardiovascular disease, metabolic syndrome, beta blockers use, race/ethnicity.

RESULTS --: Peak exercise capacity was higher for males (8.0 ± 2.1 METs) compared to females (6.7 ± 1.7 METs) (p<0.001). Exercise capacity also decreased across each decade of age (p<0.001) as well as with increasing BMI and waist circumference levels in both genders. Older age, increased waist circumference and BMI, a longer duration of diabetes, increased HbA1c, a history of CVD, having metabolic syndrome, beta blocker use, and being African American compared to white, were associated with a lower peak exercise capacity for both genders. Hypertension and use of diabetic medications were associated with lower peak exercise capacity in females.

CONCLUSIONS --: Among persons with diabetes who are overweight or obese have impaired exercise capacity, which is primarily related to: age, female sex, and race as well as poor metabolic control, BMI, and central obesity.

CiteULike    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				A. A. Gorin, H. M. Niemeier, P. Hogan, M. Coday, C. Davis, V. G. DiLillo, M. E. Gluck, T. A. Wadden, D. S. West, D. Williamson, et al. Binge Eating and Weight Loss Outcomes in Overweight and Obese Individuals With Type 2 Diabetes: Results From the Look AHEAD Trial Arch Gen Psychiatry, December 1, 2008; 65(12): 1447 - 1455. [Abstract] [Full Text] [PDF]

				R. L Marcus, S. Smith, G. Morrell, O. Addison, L. E Dibble, D. Wahoff-Stice, and P. C LaStayo Comparison of Combined Aerobic and High-Force Eccentric Resistance Exercise With Aerobic Exercise Only for People With Type 2 Diabetes Mellitus Physical Therapy, November 1, 2008; 88(11): 1345 - 1354. [Abstract] [Full Text] [PDF]