HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Online-Only Appendix All Versions of this Article: dc06-2574v1 30/9/2271    most recent Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Jonasson, J. M. Articles by Ye, W. Search for Related Content PubMed PubMed Citation Articles by Jonasson, J. M. Articles by Ye, W. Social Bookmarking                What's this?

Fertility in women with type 1 diabetes mellitus. A population-based cohort study in Sweden

¹ Medical Epidemiology and Biostatistics, Karolinska Institutet, SE 171 77, Stockholm, Sweden
² Molecular Medicine and Surgery, Karolinska Institutet, SE 171 76, Stockholm, Sweden

junmei.miao.jonasson{at}ki.se

ABSTRACT

Objective:To assess the fertility in women with type 1 diabetes and the risk of congenital malformations in their offspring.

Research Design and Method:Register-based cohort study in Sweden. All 5978 women hospitalized for type 1 diabetes mellitus at age 16 or younger identified in the Swedish Inpatient Register during 1965-2004 were followed until the end of 2004 through linkage to nationwide registers. Standardized fertility ratio (SFR), the ratio of observed to expected number of live births, with 95% confidence intervals (CIs), expressed relative fertility rate. Proportion of newborns with congenital malformations was compared to that of the general population.

Results:We observed 4013 live births (SFR=0.80, 95%CI 0.77-0.82). The SFRs for those who had retinopathy, nephropathy, neuropathy or cardiovascular complications were 0.63, 0.54, 0.50 and 0.34, respectively. Stratified analyses by year of first hospitalization showed that the reduced fertility was confined to women first hospitalized before 1985, but presence of complications was associated with subfertility in all calendar-year strata. The proportions of newborns with congenital malformations decreased from 11.7% during 1973-1984 to 6.9% during 1995-2004, but were consistently higher that those of the corresponding general population.

Conclusions:Women with type 1 diabetes have reduced fertility, but it appears normalization has occurred among women with uncomplicated disease and an onset in the past 20 years. Our results suggest that the stricter metabolic control exercised in the past 20 years may have helped prevent subfertility. However, although the risk of congenital malformations has decreased, it is still higher than that of general population.

CiteULike    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				M. R. Loeken Challenges in Understanding Diabetic Embryopathy Diabetes, December 1, 2008; 57(12): 3187 - 3188. [Full Text] [PDF]

				M. C. Vantyghem, D. Vincent-Desplanques, F. Defrance-Faivre, J. Capeau, C. Fermon, A. S. Valat, O. Lascols, A. C. Hecart, P. Pigny, B. Delemer, et al. Fertility and Obstetrical Complications in Women with LMNA-Related Familial Partial Lipodystrophy J. Clin. Endocrinol. Metab., June 1, 2008; 93(6): 2223 - 2229. [Abstract] [Full Text] [PDF]