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Diabetes Care Publish Ahead of Print published online ahead of print July 12, 2007
DOI: 10.2337/dc07-0050
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Original Research

PARENTAL HISTORY AND RISK OF TYPE 2 DIABETES IN OVERWEIGHT LATINO ADOLESCENTS: A LONGITUDINAL ANALYSIS.

Louise A. Kelly, PhD1, Christianne J. Lane, MS1, Marc J. Weigensberg, MD3, Corinna Koebnick, PhD1, Christian K. Roberts, PhD1, Jaimie N. Davis, PhD1, Claudia M. Toledo-Corral, MS1, Gabriel Q Shaibi, PhD1 and Michael I. Goran, PhD1,,2

1Department of Preventive Medicine,
2Physiology and Biophysics,
3Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA

Goran{at}usc.edu

ABSTRACT

OBJECTIVE:To examine metabolic risk factors for type 2 diabetes in children and adolescents as a function of maternal versus paternal family history of type 2 diabetes, to examine if differences in these risk factors emerge during adolescent growth

RESEARCH DESIGN AND METHODS:247 overweight Latino children (baseline age = 11.1 ±1.7 yrs) with a parental history of type 2 diabetes were followed annually for 5 years (2.2 ± 1.2 observations/child) with measures of insulin sensitivity (SI), acute insulin response to glucose (AIR), and disposition index (DI). Longitudinal linear mixed effects modeling was used to evaluate the influence of maternal versus paternal family history of T2DM on changes in diabetes risk factors over age.

RESULTS:SI and DI decreased over age (ß =-0.052 and -0.033, p <0 .01). AIR, fasting and 2hr glucose increased (ß = 0.019, 0.002, 0.003, p < 0.01). Declines in SI were significantly greater in participants whose maternal grandmothers had a history of T2DM (ß = -0.03, p = 0.03). Declines in DI (ß=-0.02, p=0.04) and increases in fasting glucose were significantly influenced by maternal history of T2D (ß = 0.60, p<0.05).

CONCLUSION:Maternal, but not paternal family history for diabetes may have a significant impact on insulin dynamics, becoming more pronounced during growth in overweight Latino adolescents. Further research is clearly warranted.


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Copyright © 2007 by the American Diabetes Association.