HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) All Versions of this Article: dc07-0320v1 30/10/2579    most recent Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Uribarri, J. Articles by Vlassara, H. Search for Related Content PubMed PubMed Citation Articles by Uribarri, J. Articles by Vlassara, H. Social Bookmarking                What's this?

SINGLE ORAL CHALLENGE BY ADVANCED GLYCATION END PRODUCTS ACUTELY IMPAIRS ENDOTHELIAL FUNCTION IN DIABETIC AND NONDIABETIC SUBJECTS

Jaime Uribarri, MD^&, Alin Stirban, MD^#, Denise Sander, MS, Weijing Cai, MD^*, Monica Negrean, MS^#, Cristina E. Buenting, MS, Theodore Koschinsky, MD and Helen Vlassara, MD^*

*Division of Diabetes and Aging Research, The Brookdale Department of Geriatrics and
^&Division of Nephrology, Department of Medicine, Mount Sinai School of Medicine, New York, NY.
German Diabetes Center at the Heinrich-Heine-University, Duesseldorf, Germany and
^#Heart and Diabetes Center NRW, Ruhr-University of Bochum, Bad Oeynhausen, Germany.

jaime.uribarri{at}mssm.edu

ABSTRACT

Objective:The current study was designed to test the acute effects of dietary advanced glycation end products (AGEs) on endothelial function of diabetic and non-diabetic subjects.

Research Design and Methods:Flow-mediated dilatation (FMD) of the brachial artery and serum levels of AGEs, plasminogen activator inhibitor (PAI-1), vascular cell adhesion molecule (VCAM-1) and glucose were assessed before and after a single oral AGE challenge (1.8x10⁶ AGE U) in 44 diabetic and 10 non-diabetic subjects.

Results:The diabetic patients had higher baseline levels of serum AGEs (p=0.020), PAI-1 (p=NS) and VCAM-1 (p=0.033) and lower baseline values of FMD compared with non-diabetic subjects (p=0.032). Ninety minutes after a single oral AGE challenge, serum AGEs and PAI-1 levels increased and FMD decreased significantly in both healthy (AGEs: 7.2±0.5 to 9.3±1 U/ml, p=0.014; PAI-1: 5.4±0.4 to 6.8±0.4 ng/ml, p=0.007; and FMD: 9.9±0.7 to 7.4±0.9 %, p=0.019) and diabetic subjects (AGEs: 10.5±0.7 to 14.2±1 U/ml, p=0.020; PAI-1: 6.5±1 to 10±2 ng/ml, p=0.030 and FMD: 5.4±0.4 to 4.0±0.3 %, p=0.032). Serum glucose and VCAM-1 levels remained unchanged.

Conclusions:Significant increases in serum AGEs can occur together with altered clinical measures of endothelial dysfunction in diabetic and non-diabetic subjects following a single modest AGE-rich meal. Thus, repeated or chronic exposure to high AGE diets could over time lead to, and/or accelerate vascular disease.

CiteULike    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				E. Linden, W. Cai, J. C. He, C. Xue, Z. Li, J. Winston, H. Vlassara, and J. Uribarri Endothelial Dysfunction in Patients with Chronic Kidney Disease Results from Advanced Glycation End Products (AGE)-Mediated Inhibition of Endothelial Nitric Oxide Synthase through RAGE Activation Clin. J. Am. Soc. Nephrol., May 1, 2008; 3(3): 691 - 698. [Abstract] [Full Text] [PDF]

				P. Dandona, A. Chaudhuri, and P. Mohanty Macronutrients, Advanced Glycation End Products, and Vascular Reactivity Diabetes Care, October 1, 2007; 30(10): 2750 - 2751. [Full Text] [PDF]

				A. Stirban, M. Negrean, B. Stratmann, C. Gotting, J. Salomon, K. Kleesiek, and D. Tschoepe Adiponectin Decreases Postprandially Following a Heat-Processed Meal in Individuals With Type 2 Diabetes: An effect prevented by benfotiamine and cooking method Diabetes Care, October 1, 2007; 30(10): 2514 - 2516. [Full Text] [PDF]