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Microvascular diabetic complications in Wolfram Syndrome (DIDMOAD): an age- and duration-matched comparison with common Type 1 diabetes.

¹Department of Nutrition, Metabolic Diseases and Endocrinology, University of Méditerranée, "La Timone" Hospital, Marseille, France.;
²Department of Medical Genetics, University of Nice, "Archet-2" Hospital, Nice, France.;
³French Group of Wolfram Syndrome (see appendix), ALFEDIAM, Paris, France

bernard.vialettes{at}ap-hm.fr

ABSTRACT

Objective:Some previous studies suggested that patients suffering from Wolfram syndrome (DIDMOAD) might be relatively preserved from diabetic retinopathy and nephropathy. However these data were not conclusive because either observations were only anecdotic or not matched with control T1DM populations.

Research Design and Methods:A group of 26 French diabetic patients with DIDMOAD was compared to a population of 52 patients with common type 1 diabetes matched for age at diabetes diagnosis (8.62 ± 1.84 yrs vs. 8.27 ± 1.30 yrs; p=NS) and diabetes duration (12.88 ± 1.58 yrs vs. 12.87 ± 1.13 yrs; p=NS) to study the quality of glycemic control and the incidence of microvascular complications.

Results:The glycemic control was significantly better in the DIDMOAD group than in the T1DM group (HbA1c: 7.72+/-0.21 % vs. 8.99+/-0.25 % respectively; p=0.002) with significant lower daily insulin requirements (0.71 ± 0.07 ui/kg/day vs. 0.88 ± 0.04 ui/kg/day respectively; p=0.0325). The prevalence of microvascular complications in the DIDMOAD group was half that observed in the T1DM group but the difference was not significant.

Conclusions:Diabetes in DIDMOAD patients is more easily controlled despite the presence of other handicaps. This better glycemic control could explain the trend to decreased micro vascular diabetic complications observed in previous studies.

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