HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) All Versions of this Article: dc07-0457v1 30/12/3125    most recent Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Corpeleijn, E. Articles by Blaak, E.E. Search for Related Content PubMed PubMed Citation Articles by Corpeleijn, E. Articles by Blaak, E.E. Social Bookmarking                What's this?

Lifestyle Intervention and Adipokine Levels in Subjects at High Risk for Type 2 Diabetes - The SLIM Study

¹ Human Biology, Nutrition and Toxicology Research Institute NUTRIM, Maastricht, The Netherlands
² Human Nutrition, Wageningen University and Research Center, Wageningen, The Netherlands
³ Centre for Nutrition and Health, National Institute for Public Health and Environment, Bilthoven, The Netherlands
⁴ Laboratory for Toxicology, Pathology and Genetics, National Institute for Public Health and Environment, Bilthoven, The Netherlands

E.Corpeleijn{at}hb.unimaas.nl

ABSTRACT

We investigated whether circulating adipokine concentrations can be altered by lifestyle intervention according to general recommendations in subjects at risk for diabetes as well as the potential of leptin, adiponectin and resistin as biomarkers for lifestyle-induced improvements in glucose metabolism and insulin resistance.

In the SLIM study, 147 men and women with impaired glucose tolerance (IGT) were randomized to either a combined diet-and-exercise intervention or a control program. At baseline and after one year, an oral glucose tolerance test, an exercise test and anthropometric measurements were performed. After one year, complete data of 103 subjects (50 intervention/53 control) were obtained.

Lifestyle intervention reduced plasma leptin concentrations (-14.2%) in IGT subjects, but did not alter plasma adiponectin (-0.3%) or resistin (-6.5%) concentrations, despite marked improvements in glucose tolerance and insulin resistance. Changes in leptin concentration were related to improvements in insulin sensitivity independent of changes in body composition.

CiteULike    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				L. Stehno-Bittel Intricacies of Fat Physical Therapy, November 1, 2008; 88(11): 1265 - 1278. [Abstract] [Full Text] [PDF]