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White Blood Cells Telomere Length is Shorter in Males with Type 2 Diabetes and Microalbuminuria

¹1^st Department of Propaedeutic Medicine, Athens University Medical School, Laiko Hospital, Athens, Greece
²Centre de Geriatrie, University of Nancy, CHU Nancy-Brabois, Nancy, France
³Laboratory for Experimental Surgery and Surgical Research, Athens University Medical School, Athens, Greece
⁴Inserm U684, Faculty of Medicine, University of Nancy, France

ntentol{at}med.uoa.gr

ABSTRACT

Objective:To examine differences in telomere (TRF) length and pulse wave velocity (PWV)-an index of arterial stiffness-in patients with type 2 diabetes mellitus (T2DM) with and without microalbuminuria (MA).

Research Design and Methods:Eighty four males with T2DM, 40 with MA and 44 without MA (age 63.5 ± 9.0 vs. 61.2 ± 9.8 years) were studied. TRF length was determined in white blood cells. MA was defined as albumin excretion (AER) rate in the range of 30-300 mg/24 hours in at least two out of three 24 hours urine collections. PWV was assessed using applanation tonometry. Markers of oxidative stress were also measured.

Results:TRF length was shorter in patients with MA than in those without MA (6.64 ± 0.74 vs. 7.23 ± 1.01 kb, respectively, P=0.004). PWV was significantly higher in the patients with MA. Multivariate linear regression analysis in the total sample demonstrated an independent association between TRF length and age (P=0.02), MA status (P=0.04) or AER (P=0.002), and plasma nitrotyrosine levels (P=0.02). AER was associated significantly with PWV (P<0.01).

Conclusions:Subjects with T2DM and MA have shorter TRF length and increased arterial stiffness than those without MA. Additionally, TRF length is associated with age, AER, and nitrosative stress. As shorter TRF length indicates older biological age, the increased arterial stiffness in patients with T2DM who have MA may be due to the more pronounced ‘aging' of these subjects.

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