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Diabetes Care Publish Ahead of Print published online ahead of print September 21, 2007
DOI: 10.2337/dc07-0699
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Original Research

Impaired postprandial blood flow in the adipose tissue may be an early marker of insulin resistance in type 2 diabetes.

George Dimitriadis, MD, DPhil1, Vaia Lambadiari, MD1, Panayota Mitrou, MD1, Eirini Maratou, PhD2, Eleni Boutati, MD1, Demosthenes B. Panagiotakos, PhD3, Theofanis Economopoulos, MD1 and Sotirios A. Raptis, MD1,,2

1Internal Medicine, Athens University, Athens, Greece,
2Hellenic National Center for Research, Prevention and Treatment, Athens, Greece,
3Nutrition Science - Dietetics, Harokopio University, Athens, Greece

gdimi{at}ath.forthnet.gr

gdimitr{at}med.uoa.gr

ABSTRACT

Objective: We investigated the changes in subcutaneous adipose tissue blood flow (ATBF) after a meal in the various stages of type 2 diabetes (T2D).

Research Design and Methods: Five groups were examined: healthy (controls), first degree relatives of subjects with T2D (relatives), subjects with impaired glucose tolerance (IGT), subjects with T2D with postprandial hyperglycemia and normal fasting plasma glucose levels (DMA) and subjects with T2D with both postprandial and fasting hyperglycemia (DMB). ATBF was measured with 133Xe.

Results: ATBF was higher in controls (1507±103ml/100cctissue*min) versus relatives, IGT, DMA, DMB (845±123, 679±69, 765±60, 757±69ml/100cctissue*min respectively, p<0.001). Insulin sensitivity index (ISI) in controls (82±3mg*l2/mmol*mU*min) was higher versus relatives, IGT, DMA, DMB (60±3, 45±1, 40±6 and 29±4mg*l2/mmol*mU*min respectively, p<0.0001). ISI was positively associated with peak-baseline ATBF (b-coefficient 0.029±0.013, p=0.03).

Conclusions: After meal ingestion, insulin-stimulated ATBF was decreased in relatives, IGT, DMA and DMB. This defect could be an early marker of insulin resistance that precedes the development of T2D.


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Copyright © 2007 by the American Diabetes Association.