HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) All Versions of this Article: dc07-0720v1 30/10/2517    most recent Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Valdez, R. Articles by Khoury, M. J. Search for Related Content PubMed PubMed Citation Articles by Valdez, R. Articles by Khoury, M. J. Social Bookmarking                What's this?

Family history and prevalence of diabetes in the US population: 6-year results from the National Health and Nutrition Examination Survey (NHANES, 1999–2004)

National Office of Public Health Genomics Coordinating Center for Health Promotion Centers for Disease Control and Prevention

rvaldez{at}cdc.gov

ABSTRACT

OBJECTIVE:To test the association between stratified levels of familial risk of diabetes and the prevalence of the disease in the US population.

RESEARCH DESIGN AND METHODS:This study includes 16,388 adults interviewed for the National Health and Nutrition Examination Survey between 1999 and 2004. Fasting glucose was available for a sub-sample of 6,004 participants. Familial risk of diabetes was classified as average, moderate, or high. The prevalence and the odds of having diabetes were estimated for each risk class after accounting for other risk factors.

RESULTS:Overall, 69.8% of the US adults were in the average, 22.7% in the moderate, and 7.5% in the high familial risk for diabetes. The crude prevalence of diabetes for each risk class was 5.9%, 14.8% and 30%, respectively. The graded association between familial risk and prevalence of diabetes remained even after accounting for sex, race/ethnicity, age, body mass index, hypertension, income, and education. Versus people in the average risk class, independently of other risk factors considered, the odds of having diabetes for people in the moderate and high familial risk categories were, respectively, 2.3 and 5.5 times higher.

CONCLUSION:In the US population, family history of diabetes has a significant, independent and graded association with the prevalence of diabetes. This association not only highlights the importance of shared genes and environment in diabetes but also opens the possibility of formally adding family history to public health strategies aimed at detecting and preventing the disease.

CiteULike    Del.icio.us    Digg    Reddit    Technorati    What's this?