HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) All Versions of this Article: dc07-0768v1 30/11/2945    most recent Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Ng, T. W.K. Articles by Chan, D. C. Search for Related Content PubMed PubMed Citation Articles by Ng, T. W.K. Articles by Chan, D. C. Social Bookmarking                What's this?

Effect of weight loss on LDL and HDL kinetics in the metabolic syndrome: Associations with changes in plasma retinol-binding protein-4 and adiponectin levels

¹School of Medicine and Pharmacology, Metabolic Research Centre, University of Western Australia
²Lipid Research Group, The Heart Research Institute, and
³Department of Medicine, University of Sydney, Sydney, NSW, Australia

gerald.watts{at}uwa.edu.au

gerald.watts{at}uwa.edu.au

ABSTRACT

Objectives:To examine the effect of weight loss on LDL and HDL kinetics and plasma retinol-binding protein-4 (RBP-4) and adiponectin levels in men with the metabolic syndrome (MetS).

Research design and Methods:LDL-apoB-100 and HDL-apoA-I kinetics were studied in 35 obese men with the MetS at the start and end of a 16-week intervention trial of a hypocaloric, low-fat diet (n=20) versus a weight maintenance diet (n=15), using a stable isotope technique and multi-compartmental modelling.

Results:The low-fat diet achieved significant reduction (P<0.01) in BMI, abdominal fat compartments and HOMA score compared with weight maintenance. This was associated with a significant increase in adiponectin and a fall in plasma RBP-4, triglycerides, LDL-cholesterol, and LDL-apoB concentration (P<0.05). Weight loss significantly increased the catabolism of LDL-apoB (+27%, P<0.05), but did not affect production; it also decreased both the catabolic (-13%) and production (-13%) rates of HDL-apoA-I (P<0.05), thereby not altering plasma HDL-apoA-I or HDL-cholesterol concentrations. VLDL-apoB production fell significantly with weight loss (P<0.05). The increase in LDL catabolism was inversely correlated with the fall in RBP-4 (r=-0.54, P<0.05), and the decrease in HDL catabolism with the rise in adiponectin (r= -0.56, P<0.01).

Conclusion:In obese men with MetS, weight loss with a low-fat diet decreases plasma LDL-apoB concentration by increasing the catabolism of LDL-apoB; weight loss also delays the catabolism of HDL-apoA-I with a concomitant reduction in the secretion of HDL-apoA-I. These effects of weight loss could partly involve changes in RBP-4 and adiponectin levels.

CiteULike    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				M. J. Puglisi and M. L. Fernandez Modulation of C-Reactive Protein, Tumor Necrosis Factor-{alpha}, and Adiponectin by Diet, Exercise, and Weight Loss J. Nutr., December 1, 2008; 138(12): 2293 - 2296. [Abstract] [Full Text] [PDF]

				D. C. Chan, M. N. Nguyen, G. F. Watts, and P. H. R. Barrett Plasma Apolipoprotein C-III Transport in Centrally Obese Men: Associations with Very Low-Density Lipoprotein Apolipoprotein B and High-Density Lipoprotein Apolipoprotein A-I Metabolism J. Clin. Endocrinol. Metab., February 1, 2008; 93(2): 557 - 564. [Abstract] [Full Text] [PDF]