Diabetes Care
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

Diabetes Care Publish Ahead of Print published online ahead of print September 5, 2007
DOI: 10.2337/dc07-1063
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
dc07-1063v1
30/12/3077    most recent
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Baker, N.
Right arrow Articles by Rayman, G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Baker, N.
Right arrow Articles by Rayman, G.
Social Bookmarking
Add to CiteULike   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Original Research

Microvascular and C-fibre function in Diabetic Charcot Neuro-arthropathy and Diabetic Peripheral Neuropathy

Neil Baker, BSc DPodM1, Alistair Green, MRCP1, Singhan Krishnan, MRCP1 and Gerry Rayman, MD FRCP1

1Ipswich Diabetic Foot Unit and Diabetes Centre

Gerry.Rayman{at}ipswichhospital.nhs.uk

ABSTRACT

Objective: Sympathetic denervation and hyperaemia are implicated in the pathogenesis of Charcot neuro-arthropathy (CN) but also features of diabetic peripheral neuropathy (DPN). Differences in these physiological parameters were sought by determining C-fibre function (LDI flare) and maximum microvascular hyperaemia (MMH) in 13 subjects with diabetic CN (DCN), 10 diabetic neuropaths (DPN) and 10 healthy controls (HC). Additionally, unaffected limbs of the 9 DCN with unilateral charcot (UCN) were studied to determine whether any observed differences precede CN.

Results: The LDIflare was reduced in DPN (1.41 ± 0.51, cm2±SD) and DCN groups (1.42 ± 0.37) compared to HC (5.24 ± 1.33), p<0.0001. MMH was higher in DCN (432 ± 88 PU±SD) than DPN (262 ± 71), p=0.001, though lower than HC (564 ± 112) p < 0.01.

Conclusion: C-fibre function is equally impaired in neuropathic patients with and without CN, however a higher MMH distinguishes those with CN. Unaffected and affected limbs of those with unilateral CN have the same neuro-vascular abnormalities suggesting these precede rather than result from CN.


Add to CiteULike CiteULike   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Diabetes Diabetes Care Clinical Diabetes Diabetes Spectrum
Copyright © 2007 by the American Diabetes Association.