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High serum uric acid as a novel risk factor for type 2 diabetes mellitus

¹ Epidemiology & Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
² Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands

j.witteman{at}erasmusmc.nl

ABSTRACT

Objective: To investigate the association between serum uric acid level and risk of type 2 diabetes mellitus.

Research Design and Methods: The population for analysis consisted of 4536 subjects free from diabetes at baseline. During a mean of 10.1 years of follow up, 462 subjects developed diabetes.

Results: The age- and sex-adjusted hazard ratios (95% confidence interval) for diabetes were 1.30 (0.96 – 1.76) for the second, 1.63 (1.21 – 2.19) for the third, and 2.83 (2.13 – 3.76) for the fourth quartile of serum uric acid, compared to the first quartile. After adjustment for BMI, waist circumference, systolic and diastolic blood pressure, and HDL-cholesterol, the hazard ratios decreased to 1.08 (0.78 – 1.49), 1.12 (0.81 – 1.53), and 1.68 (1.22 – 2.30), respectively.

Conclusion: The results of this population-based study suggest that serum uric acid is a strong and independent risk factor for diabetes.

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