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Diabetes Care Publish Ahead of Print published online ahead of print January 9, 2008
DOI: 10.2337/dc07-1392
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Original Research

Tracking and prediction of arterial blood pressure from childhood to young adulthood in 868 patients with type 1 diabetes: A multi-center, longitudinal survey in Germany and Austria

Ina Knerr, MD, PhD1, Axel Dost, MD, PhD2, Rudolf Lepler, MD3, Klemens Raile, MD, PhD4, Edith Schober, MD, professor5, Wolfgang Rascher, MD, professor1, Reinhard W. Holl, MD, professor on behalf of the DPV Scientific Initiative Germany and Austria6

1Children's and Adolescents' Hospital, University of Erlangen-Nuremberg, Germany
2University Children's Hospital, Jena, Germany
3Children's Hospital Wilhelmstift, Hamburg, Germany
4University Children's Hospital, Berlin, Germany
5University Children's Hospital, Vienna, Austria
6Division of Applied Information Technology, University of Ulm, Germany

ina.knerr{at}uk-erlangen.de

ABSTRACT

Objective: Arterial blood pressure (BP) was followed in 868 patients with type 1 diabetes from 6.0 to 19.9 yrs of age in 95 centers in Germany and Austria.

Research Design and Methods: European BP reference data for 28,043 children and adolescents were used with respect to age and gender. Data were stratified in the 3 groups pre-pubertal, pubertal and post-pubertal.

Results: Up to 4% of the participants in the younger age groups and 13.9% of the post-pubertal patients exhibited BP values >97th centile. BP levels correlated to hemoglobin A1c and BMI z score. Tracking of BP revealed that children with elevated BP had higher BP in adolescence and young adulthood.

Conclusions: Patients with higher BP in childhood showed elevated BP later in life. We need to focus on the diagnosis of hypertension in children with type 1 diabetes, and to study the efficacy of early intervention.


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Copyright © 2008 by the American Diabetes Association.