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Diabetes Care Publish Ahead of Print published online ahead of print February 5, 2008
DOI: 10.2337/dc07-1536
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Original Research

Left ventricular function, mass, and volumes in type 1 diabetic patients – and relation to NT-proBNP

Anne Sofie Astrup, MD1, Won Yong Kim, MD2,,3, Lise Tarnow, MD1, René M. Botnar, PhD4, RT Cheryl Simonsen3, Lau Brix, MSc3, Lotte Pietraszek, Lab. Tech1, Peter Riis Hansen, MD5, Warren J. Manning, MD6 and Hans-Henrik Parving, MD7

1Steno Diabetes Center, Denmark
2Dept. of Cardiology and
3MR-center, Skejby Hospital, Denmark
4Technical University Munich, Germany
5Gentofte Hospital, Denmark
6Harvard Medical School, USA
7Rigshospitalet, Copenhagen, Denmark

Ansa{at}steno.dk

ABSTRACT

Objectives: To measure left ventricular mass (LVM), volumes and function (LVF) in a cohort of type 1 diabetic patients and to correlate measures of imaging to N-terminal pro-brain natriuretic peptide (NT-proBNP).

Design and Research Methods: In a cross sectional study, all patients with type 1 diabetes underwent cardiovascular magnetic resonance imaging (CMR). We included 63 patients with diabetic nephropathy and 73 patients with normoalbuminuria.

Results: All patients had normal global LVF. LVM were increased in patients with diabetic nephropathy compared to patients with persistent normoalbuminuria. Patients with nephropathy had smaller left ventricular volumes and levels of NT-proBNP were increased.

Linear regression analysis in patients with diabetic nephropathy showed that NT-proBNP and creatinine were associated with LVM.

Conclusions: Increased LVM is identified in asymptomatic type 1 diabetic patients with nephropathy compared to normoalbuminuric patients. Elevated levels of NT-proBNP were associated with increased LVM– both markers of increased cardiovascular risk.


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Copyright © 2008 by the American Diabetes Association.