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Diabetes Care Publish Ahead of Print published online ahead of print October 31, 2007
DOI: 10.2337/dc07-1646
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Original Research

SQUATTING AMPLIFIES PULSE PRESSURE INCREASE WITH DISEASE DURATION IN PATIENTS WITH TYPE 1 DIABETES

Jean-Christophe Philips, MD1, Monique Marchand1 and André J. Scheen, MD, PhD1

1Division of Diabetes, Nutrition and Metabolic Disorders, Department of Medicine, CHU Sart Tilman, B-4000 Liège, Belgium

andre.scheen{at}chu.ulg.ac.be

ABSTRACT

Objective: To evaluate pulse pressure (PP) changes according to duration of type 1 diabetes mellitus (T1DM) and to assess the influence of posture.

Research Design and Methods: Continuous measurement of blood pressure with a Finapres® device during a 3x1min posture test (standing-squatting-standing) in 159 T1DM patients divided into four groups according to diabetes duration (≤10 years, 11-20 years, 21-30 years and >30 years from group 1 to group 4, respectively) and compared to age-matched nondiabetic subjects.

Results: PP progressively increased according to T1DM duration (p<0.0001), especially in women, but not in age-matched nondiabetic subjects (NS). PP increase from group 1 to group 4 was amplified in squatting position (from 50±17 to 69±14 mmHg) compared to standing (from 44±15 to 55±12 mmHg).

Conclusion: PP increases according to T1DM duration, more in women than in men, and the squatting position sensitizes such PP increase in both genders.


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Copyright © 2007 by the American Diabetes Association.