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Diabetes Care Publish Ahead of Print published online ahead of print October 1, 2007
DOI: 10.2337/dc07-1711
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Original Research

The Effect of Cinnamon on Glucose Control and Lipid Parameters

William L Baker, Pharm.D., BCPS1,,2, Gabriela Gutierrez-Williams, Pharm.D.2, C. Michael White, Pharm.D., FCP, FCCP1,,2, Jeffrey Kluger, MD3 and Craig I Coleman, Pharm.D.1,,2

University of Connecticut1,
Storrs, CT and Drug Information2
and Cardiology3 at Hartford Hospital, Hartford, CT

ccolema{at}harthosp.org

ABSTRACT

Objective –: To perform a meta-analysis of randomized controlled trials of cinnamon to better characterize its impact on glucose and plasma lipids.

Research Design & Methods –: A systematic literature search through July 2007 was conducted to identify randomized, placebo-controlled trials of cinnamon that reported data on hemoglobin A1c (HbA1c), fasting blood glucose (FBG) or lipid parameters. The mean change in each study endpoint from baseline was treated as a continuous variable and the weighted mean difference was calculated as the difference between the mean value in the treatment and control groups. A random-effects model was used.

Results –: Five prospective, randomized controlled trials (n=282) were identified. Upon meta-analysis, the use of cinnamon did not significantly alter HbA1c, FBG, or lipid parameters. Subgroup and sensitivity analyses did not significantly change the results.

Conclusion –: Cinnamon does not appear to improve HbA1c, FBG or lipid parameters in patients with type 1 or 2 DM.


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Copyright © 2007 by the American Diabetes Association.