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Diabetes Care Publish Ahead of Print published online ahead of print January 17, 2008
DOI: 10.2337/dc07-1781
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Original Research

Ethnic Differences in the Relationship between Adiponectin and Insulin Sensitivity in South Asian and Caucasian Women

Marlene Martin, B.A.1, Latha P. Palaniappan, M.D., M.S.2, Andrea C. Kwan, B.A.3, Gerald M. Reaven, M.D.4 and Peter D. Reaven, M.D.5

1 Stanford University School of Medicine, Stanford, CA
2 Palo Alto Medical Foundation Research Institute, Department of Health Care and Policy Research, Palo Alto, CA
3 University of California, San Diego, CA
4 Falk CVRC, Div. of Cardiovascular Medicine, Stanford University, Stanford, CA
5 Carl T. Hayden Veterans Affairs Medical Center, Dept. of Medicine, Phoenix, AZ

greaven{at}cvmed.stanford.edu

ABSTRACT

Objective: To assess whether lower adiponectin concentrations in South Asian (SA) Indians may be responsible for their greater degree of insulin resistance.

Research Design and Methods: Insulin-mediated glucose uptake and plasma total and HMW adiponectin concentrations were quantified in 52 women of SA and Caucasian (CAU) ancestry and compared.

Results: Mean (± SD) total (2965 ± 1278 vs. 4235 ± 160) and HMW (1001 ± 352 vs. 1591 ± 854) adiponectin (ng/mL) were lower (p<0.005) in SA. CAU-IR had lower (p<0.01) total (2665 ± 1040 vs. 5133 ± 1086) and HMW (987±479 vs.1935 ±838) adiponectin than CAU-IS, but there were no significant differences between IR and IS SA. HMW adiponectin did not differ between SA-IR and CAU-IR, but SA-IS had significantly lower adiponectin concentrations than CAU-IS.

Conclusions: Insulin resistance status is not associated with significantly lower levels of adiponectin in these SA women, in contrast to the CAU women.


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