HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) All Versions of this Article: dc07-1926v1 31/5/952    most recent Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Reaven, P. D. Search for Related Content PubMed PubMed Citation Articles by Reaven, P. D. Social Bookmarking                What's this?

Proliferative Diabetic Retinopathy in Type 2 Diabetes is Related to Coronary Artery Calcium in the Veterans Affairs Diabetes Trial (VADT)

¹Carl T Hayden VAMC
²Hines VAMC
³Cooperative Studies Program Coordinating Center, Hines VAMC
⁴University of Wisconsin, Madison
⁵Miami VAMC

Peter.Reaven{at}va.gov

ABSTRACT

Objective: Increasing evidence suggests that macrovascular disease and retinopathy (RET) may be more closely linked than previously believed. We determined the relationship between RET and coronary atherosclerosis as measured by CT detectable coronary artery calcium (CAC).

Research Design and Methods: The cross-sectional association between CAC and RET was assessed on a VADT sub-sample of 204 subjects with a mean duration of type 2 diabetes of 12.3 ± 8.3 years.

Results: RET was correlated with CAC (r=0.19, p=0.006). Median CAC increased across RET categories: 197 in those with no RET, 229 with microaneurysms only, 364 with mild non-proliferative diabetic RET (NPDR), 300 with moderate to severe NPDR, and 981 in those with proliferative diabetic RET (PDR). Stepwise multivariable linear regression analysis was performed to find a parsimonious subset of relevant risk factors to include along with PDR in predicting CAC. After adjustment for either this subset of standard factors (p = 0.047) or a more extensive panel of risk factors (p = 0.035), PDR was significantly associated with CAC. Moreover, using logistic regression, individuals with PDR were approximately 6 fold more likely to have CAC > 400 compared to those with no PDR, even after adjustment for other CVD risk factors.

Conclusions: These data indicate an important relationship between RET and extent of coronary atherosclerosis (CAC), and suggest the potential to identify and treat shared risk factors for these common micro- and macrovascular complications.

CiteULike    Del.icio.us    Digg    Reddit    Technorati    What's this?