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Coffee consumption is associated with higher plasma adiponectin concentrations in women with and without type 2 diabetes: a prospective cohort study

¹Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA
²Department of Nutrition, Harvard School of Public Health, Boston, MA
³Department of Epidemiology, Harvard School of Public Health, Boston, MA
⁴Channing Laboratory, Brigham and Women's Hospital, Boston, MA
⁵Department of Surgery, Beth Israel Deaconess Medical Center, Boston, MA

cmantzor{at}bidmc.harvard.edu

ABSTRACT

To test whether the beneficial effects of coffee consumption in metabolism might be explained by changes in circulating levels of adiponectin, we evaluated self-reported habitual coffee and tea consumption and caffeine intake as predictors of plasma adiponectin concentrations among 982 diabetic and 1058 non-diabetic women without cardiovascular disease from the Nurses' Health Study. Women with and without diabetes who drank 4 cups of coffee per day had significantly higher adiponectin concentrations than those who didn't drink coffee regularly (7.7µg/ml vs. 6.1µg/ml, P=0.004; 15.0µg/ml vs. 13.2µg/ml in non-diabetics, P=0.04). Similar associations were observed for caffeine intake. We confirm previously reported inverse associations of coffee consumption with inflammatory markers, C-reactive protein and TNF- receptor II. Adjustment for adiponectin did not weaken these associations, nor did adjustment for inflammatory markers attenuate the association between coffee consumption and adiponectin. High consumption of caffeine-containing coffee is associated with higher adiponectin and lower inflammatory marker concentrations.

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				K. Kotani, S. Fujiwara, T. Hamada, K. Tsuzaki, and N. Sakane Coffee Consumption Is Associated With Higher Plasma Adiponectin Concentrations in Women With or Without Type 2 Diabetes: Response to Williams et al. Diabetes Care, May 1, 2008; 31(5): e46 - e46. [Full Text] [PDF]

				R. M. van Dam, F. B. Hu, and C. S. Mantzoros Coffee Consumption Is Associated With Higher Plasma Adiponectin Concentrations in Women With or Without Type 2 Diabetes: Response to Kotani et al. Diabetes Care, May 1, 2008; 31(5): e47 - e47. [Full Text] [PDF]