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Diabetes Care Publish Ahead of Print published online ahead of print February 14, 2008
DOI: 10.2337/dc07-1962
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Original Research

Serum prostate-specific antigen level in men with type 2 diabetes

Michiaki Fukui, MD1, Muhei Tanaka, MD1, Mayuko Kadono, MD1, Saeko Imai, PhD2, Goji Hasegawa, MD1, Toshikazu Yoshikawa, MD1 and Naoto Nakamura, MD1

1Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan
2Department of Clinical Nutrition, Faculty of Comprehensive Rehabilitation, Osaka Prefecture University, Osaka, Japan

sayarinapm{at}hotmail.com

ABSTRACT

Objective: The aims of this study were to examine if serum prostate-specific antigen (PSA) levels are lower in men with type 2 diabetes compared with those in healthy men, and to investigate what factors may be associated with serum PSA levels in men with type 2 diabetes.

Research Design And Methods: We compared the serum PSA levels in 224 diabetic men with those in 1293 healthy men, and investigated the relationships between serum PSA levels and various variables.

Results: Except for age group 40-49, serum PSA levels were lower in diabetic men than in healthy men. Multiple regression analysis demonstrated that age, BMI, and presence of diabetes were independent determinants of serum PSA level.

Conclusions: Serum PSA levels were lower in diabetic men compared with those in healthy men, which is in line with previous reports that patients with type 2 diabetes are at a decreased risk of prostate cancer.


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Copyright © 2008 by the American Diabetes Association.