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Diabetes Care Publish Ahead of Print published online ahead of print March 10, 2008
DOI: 10.2337/dc07-2001
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Original Research

Markedly blunted metabolic effects of fructose in healthy young females compared to males

Caroline Couchepin, MD, Kim-Anne Lê, MSc, Murielle Bortolotti, MSc, Joana Amarante da Encarnaçao, BSc, Jean-Baptiste Oboni, BSc, Christel Tran, MD, Philippe Schneiter, PhD and Luc Tappy, MD

1Department of Physiology, Lausanne University School of Biology and Medicine, Lausanne Switzerland

luc.tappy{at}unil.ch

ABSTRACT

Objective: to compare the metabolic effects of fructose in healthy males and females

Research Design And Methods: Fasting metabolic profile and hepatic insulin sensitivity were assessed by means of a hyperglycemic clamp in 16 healthy young males and female subjects after a 6-day fructose overfeeding

Results: Fructose overfeeding increased fasting triglyceride concentrations by 71% in males vs 16% in females (p<0.05). Endogenous glucose production was increased by 12%, alanin aminotransferase concentration was increased by 38%, and fasting insulin concentrations was increased by 14% after fructose overfeeding in males (all p<0.05), but were not significantly altered in females. Fasting plasma free fatty acids and lipid oxidation were inhibited by fructose in males, but not in females

Conclusions: Short term fructose overfeeding produces hypertriglyceridemia and hepatic insulin resistance in males, but these effects are markedly blunted in healthy young females.


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