HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) All Versions of this Article: dc07-2185v1 31/5/1021    most recent Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Hohberg, C. Articles by Pfützner, A. Search for Related Content PubMed PubMed Citation Articles by Hohberg, C. Articles by Pfützner, A. Social Bookmarking                What's this?

Effect of Insulin Glulisine on Microvascular Blood Flow and Endothelial Function in the Postprandial State

¹Institute for Clinical Research and Development, Mainz, Germany
²Johannes Gutenberg University, Dept. Endocrinology, Mainz, Germany
³sanofi-aventis, Berlin, Germany

thomasf{at}ikfe.de

ABSTRACT

OBJECTIVE: To investigate the effect of insulin glulisine on postprandial microvascular blood flow in T2DM.

RESEARCH DESIGN AND METHODS: Fifteen patients with T2DM received insulin glulisine or human insulin before a liquid meal test. Thereafter, skin microvascular blood flow was measured by the use of laser Doppler fluxmetry (LDF), and blood samples were taken for the meaurement of plasma levels of glucose, insulin, intact proinsulin, ADMA, nitrotyrosine, IL-18, MMP-9, oxLDL, and FFA.

RESULTS: Insulin glulisine resulted in higher postpradial insulin levels (mean±SEM; AUC_0–120:51.0±6.8 vs. 38.2±5.4 mU/L; p=0.004), while plasma glucose (AUC_0–240: 158±9 vs. 180±9 mg/dl; p<0.05) and intact proinsulin (AUC_0–240: 26.2±3.5 vs 31.2±4.3 pmol/L; p=0.002) were lower. Microvascular blood flow increased after insulin glulisine (27.9±3.1 to 51.7±9.9 AU; p<0.05), while only a minor increase was found during human insulin (27.9±3.1 to 34.4±7.8; n.s.). ADMA and Nitrotyrosine levels were reduced after insulin glulisine (p<0.05, respectively).

CONCLUSIONS: Insulin glulisine is superior to human insulin in restoring postprandial metabolic and microvascular physiology.

CiteULike    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				M. G. Clark Impaired microvascular perfusion: a consequence of vascular dysfunction and a potential cause of insulin resistance in muscle Am J Physiol Endocrinol Metab, October 1, 2008; 295(4): E732 - E750. [Abstract] [Full Text] [PDF]