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Diabetes Care Publish Ahead of Print published online ahead of print March 10, 2008
DOI: 10.2337/dc07-2243
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Original Research

Hypoglycemia Increases Serum Interleukin-6 Levels in Healthy Men and Women (Hypoglycemia and IL-6)

Sarah Dotson, BA1, Roy Freeman, MD2, Hannah J. Failing, BA1 and Gail K. Adler, MD, PhD1

1Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women's Hospital, Boston, MA
2Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA

gadler{at}partners.org

ABSTRACT

Objective: Inflammation may have a major role in the pathogenesis and prognosis of critical illness. Hyperglycemia increases levels of the inflammatory cytokine interleukin-6 (IL-6) and is associated with increased risks of morbidity and mortality. Since hypoglycemia is also associated with adverse outcomes, we tested the hypothesis that hypoglycemia increases IL-6.

Research Design and Methods: Seventeen healthy men and women participated in hypoglycemic and euglycemic hyperinsulinemic clamp studies (target blood glucose 2.7 and 5.0 mmol/l, respectively), separated in time by 1-3 months. IL-6, ACTH, and cortisol were measured at baseline and 45, 75, 105 and 135 minutes after initiation of the insulin infusion.

Results: IL-6, ACTH, and cortisol increased significantly (p<0.0001) during hypoglycemia but not euglycemia. IL-6 increased from 1.0 ± 0.2 pg/ml at baseline to 2.6 ± 0.2 pg/ml after 135 minutes of hypoglycemia, whereas IL-6 levels were unchanged during euglycemia.

Conclusions: Hypoglycemia increases IL-6 levels in healthy individuals.


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