HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) All Versions of this Article: dc08-0219v1 31/7/1439    most recent Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Tesauro, M. Articles by Cardillo, C. Search for Related Content PubMed PubMed Citation Articles by Tesauro, M. Articles by Cardillo, C. Social Bookmarking                What's this?

TNF- Antagonism Improves Vasodilation During Hyperinsulinemia in Metabolic Syndrome

Manfredi Tesauro, MD^*, Francesca Schinzari, MD, Valentina Rovella, MD^*, Domenico Melina, MD, Nadia Mores, MD, Angela Barini, MD, Marco Mettimano, MD, Davide Lauro, MD, Micaela Iantorno, MD, Michael J. Quon, MD, PhD and Carmine Cardillo, MD

*Università di Tor Vergata, Rome, Italy
Università Cattolica del Sacro Cuore, Rome, Italy; and
NCCAM, NIH, Bethesda, MD, USA

carmine.cardillo{at}rm.unicatt.it

ABSTRACT

Objective: Obesity is associated with chronic inflammation due to overproduction of proinflammatory cytokines, including TNF-. We assessed the effects of TNF- neutralization by infliximab on vascular reactivity during hyperinsulinemia in obesity-related metabolic syndrome (MetS).

Research Design and Methods: Vascular responses to intra-arterial infusion of acetylcholine (ACh) and sodium nitroprusside (SNP) were assessed in patients with MetS, before and after administration of infliximab.

Results: Patients had blunted vasodilator responses to ACh and SNP during hyperinsulinemia compared with controls; a potentiation of the responsiveness to both ACh and SNP, however, was observed in patients following infliximab. The antioxidant vitamin C improved the vasodilator response to ACh in patients with MetS, but its effect was not further enhanced by concurrent administration of infliximab.

Conclusions: TNF- neutralization ameliorates vascular reactivity in MetS during hyperinsulinemia, likely in relation to decreased oxidative stress, thereby suggesting an involvement of inflammatory cytokines in vascular dysfunction of these patients.

CiteULike    Del.icio.us    Digg    Reddit    Technorati    What's this?