Renal Excretion of Prostaglandin E2 and Plasma Renin Activity in Type I Diabetes Mellitus: Relationship to Normoglycemia Achieved With Artificial Pancreas
- Enrique Esmatjes, MD,
- Isaac Levy, MD,
- Juan Gaya, MD and
- Francisca Rivera, MD
- Endocrinology and Diabetes Unit, Hormonal Laboratory, Hospital Clinic i Provincial, University of Barcelona Catalonia, Spain
- Address correspondence and reprint requests to E. Esmatjes, MD, Endocrinology and Diabetes Unit, Hospital Clinic, Villarroel 170, 08036 Barcelona, Spain.
Abstract
To determine the effect of normoglycemia on renal prostaglandin synthesis and renin-angiotensin system activity, prostaglandin E2 (PGE2) urinary excretion, plasma renin activity (PRA), and glomerular filtration rate (GFR) were studied in seven patients with insulin-dependent diabetes mellitus (IDDM) without complications, both in basal conditions and after a 20-h treatment with an artificial pancreas. Normoglycemia induced a significant reduction in PGE2 excretion (88 ± 23 vs. 55 ± 25 ng/12 h, P < .05) and GFR (138 ± 34 vs. 105 ± 20 ml · min−1 · 1.73 m−2, P < .05) and a nonsignificant increment of PRA (0.52 ± 0.48 vs. 0.83 ± 0.92 ng · ml−1 · h−1). The results enhance the hypothesis that renal prostaglandins play a role in the renal functional alterations observed in IDDM during hyperglycemia.
- Copyright © 1987 by the American Diabetes Association
