Effect of Hematocrit Concentration on Blood Glucose Value Determined on Glucometer II

  1. Joseph E Buttery, PhD
  1. Department of Clinical Chemistry, The Queen Elizabeth Hospital Woodville, Australia
  1. Address correspondence and reprint requests to J. E. Buttery, Department of Clinical Chemistry, The Queen Elizabeth Hospital, Woodville, S. A. 5011, Australia.

Abstract

Nineteen patient blood samples each with modified hematocrit concentrations of ∼20, 30, 40, 50, and 60%, were assayed for their glucose concentration by the Glucometer II. Blood removal from the test strip was by the one- and two-blot techniques. The reference method was the Yellow Springs Instruments (YSI) blood glucose analyzer. Glucometer II results were falsely high for the single blot (13–59%, mean 33%) and double blot (12–41%, mean 19%) at 20% hematocrit and falsely low at 60% hematocrit for the single blot (22–44%, mean 37%) and the double blot (26–49%, mean 43%). At 40- 50% hematocrit, Glucometer II and YSI results agreed only for the one-blot technique.

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